Protrusion-localized STAT3 mRNA promotes metastasis of highly metastatic hepatocellular carcinoma cells in vitro

• Published in: Acta pharmacologica Sinica Vol. 37; no. 6; pp. 805 - 813
• Main Authors: Liu, Yan-hong, Jin, Jia-lu, Wang, Yu-zhe, Tan, Ying, Zhou, Ying-ying, Peng, Ting, Li, Feng, Liang, Wan-dong, Chartrand, Pascal, Jiang, Yu-yang, Shen, Zhi-fa
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2016; Nature Publishing Group
• Subjects: Biomedical and Life Sciences; Biomedicine; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Cell Line, Tumor; Cell Movement; Humans; Immunology; Internal Medicine; Liver - metabolism; Liver - pathology; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Medical Microbiology; mRNA定位; Neoplasm Invasiveness - genetics; Neoplasm Invasiveness - pathology; Neoplasm Metastasis - genetics; Neoplasm Metastasis - pathology; Original; original-article; Pharmacology/Toxicology; RNA, Messenger - analysis; RNA, Messenger - genetics; SMMC-7721细胞; STAT3; STAT3 Transcription Factor - genetics; Vaccine; 体外; 本地化; 突出; 肝癌细胞; 血小板衍生生长因子; mRNA localization; metastasis; SMMC-7721 cells; STAT3; platelet-derived growth factor receptor; Boyden chamber assay; HCCLM3 cells; hepatocellular carcinoma

Aim： Recent evidence shows that localization of mRNAs and their protein products at cellular protrusions plays a decisive function in the metastasis of cancer cells. The aim of this study was to identify the variety of proteins encoded by protrusion-localized mRNAs and their roles in the metastasis...