Intranasal cocaine in humans: Effects of sex and menstrual cycle

• Published in: Pharmacology, biochemistry and behavior Vol. 86; no. 1; pp. 117 - 124
• Main Authors: Collins, Stephanie L., Evans, Suzette M., Foltin, Richard W., Haney, Margaret
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.01.2007; Elsevier Science
• Subjects: Administration, Intranasal; Adult; Biological and medical sciences; Cardiovascular effects; Cluster Analysis; Cocaine; Cocaine - administration & dosage; Cocaine - blood; Cocaine - pharmacology; Cocaine-Related Disorders - physiopathology; Cocaine-Related Disorders - psychology; Dopamine Uptake Inhibitors - administration & dosage; Dopamine Uptake Inhibitors - blood; Dopamine Uptake Inhibitors - pharmacology; Dose-Response Relationship, Drug; Female; Follicular Phase - physiology; Hormones - blood; Humans; Luteal Phase - physiology; Male; Medical sciences; Menstrual Cycle; Menstrual Cycle - physiology; Neuropharmacology; Pharmacology. Drug treatments; Plasma levels; Psychiatric Status Rating Scales; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Sex Characteristics; Sex Differences; Subjective effects; Surveys and Questionnaires; Sex Differences; Humans; Subjective effects; Cardiovascular effects; Menstrual Cycle; Cocaine; Plasma levels; Human; Biological fluid; Menstrual cycle; CNS stimulant; Psychotropic; Sex; Intranasal administration; Blood plasma; Ester; Drug of abuse; Circulatory system

Studies have shown that smoked and intravenous cocaine's effects differ in cocaine-dependent women compared to men and across the menstrual cycle. However, this has not been systematically investigated with intranasal cocaine. Thus, a range of intranasal cocaine doses was examined in cocaine-de...