Genetic exploration of the role of acid-sensing ion channels

• Published in: Neuropharmacology Vol. 94; pp. 99 - 118
• Main Authors: Lin, Shing-Hong, Sun, Wei-Hsin, Chen, Chih-Cheng
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2015
• Subjects: Acid Sensing Ion Channels - genetics; Acid Sensing Ion Channels - metabolism; Animals; ASIC; Gene Knockout Techniques; Gene targeting; Knockout; Mechanotransduction; Mice, Knockout; Pain; Phenotype; ASIC; Phenotype; Mechanotransduction; Gene targeting; Pain; Knockout

Advanced gene targeting technology and related tools in mice have been incorporated into studies of acid-sensing ion channels (ASICs). A single ASIC subtype can be knocked out specifically and screened thoroughly for expression in the nervous system at the cellular level. Mapping studies have furthe...