The Significance of FDG PET/CT-Derived Parameters in Determining Prognosis of Cases with Pancreatic Adenocarcinoma: A Prospective Study
Background and objectives: Pancreatic adenocarcinoma represents one of the common malignancies with a relatively poor prognosis. However, early detection of this type of cancer may prove to be curable. Recent advancements in the radiological techniques might represent a hope for the early diagnosis...
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Published in | Medicina (Kaunas, Lithuania) Vol. 58; no. 8; p. 1027 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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01.08.2022
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Abstract | Background and objectives: Pancreatic adenocarcinoma represents one of the common malignancies with a relatively poor prognosis. However, early detection of this type of cancer may prove to be curable. Recent advancements in the radiological techniques might represent a hope for the early diagnosis and prediction of prognosis of pancreatic adenocarcinoma. This study aimed to assess the prognostic value of the primary tumor volumetric parameters obtained from FDG PET/CT first stage for the overall survival (OS) and progression-free survival (PFS) of patients with pancreatic adenocarcinoma and to explore the possible correlation between serum matrix metalloproteinase-2 (MMP-2) and the patients’ characteristics. Methods: Fifty patients with pancreatic adenocarcinoma were subjected to FDG PET/CT scan. The SUVpeak, SUVmax, and the metabolic tumor volume (MTV) were determined, as well as the SUVmean of the liver. Moreover, serum levels of MMP-2 were assessed. Follow-up of the patients was carried out for sixty months with determination of PFS and OS. Results: Peak SUV ≥ 3.9 was significantly correlated with the primary pancreatic lesions’ mean total glycolytic activity of >92 g, and MTV and was directly correlated with mortality. There was a positive correlation between peak SUV ≥ 3.9 and 50% SUVmax threshold > 82. Moreover, there was significant correlation between the total glycolytic activity and the studied clinicopathologic factors, except the age and sex of the patients and ECOG performance status. In addition, FDG uptake and the tumor glycolytic activity were substantially linked with a shorter PFS. Similarly, a strong correlation was found between MTV and PFS. Serum MMP-2 levels showed a significant relationship with the performance status, tumor stage, SUVmax threshold, and the glycolytic activity. Conclusions: Peak SUV, main lesion SUVmax, serum MMP-2, and the tumor glycolytic activity are good predictors of PFS of patients with pancreatic adenocarcinoma. |
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AbstractList | Background and objectives: Pancreatic adenocarcinoma represents one of the common malignancies with a relatively poor prognosis. However, early detection of this type of cancer may prove to be curable. Recent advancements in the radiological techniques might represent a hope for the early diagnosis and prediction of prognosis of pancreatic adenocarcinoma. This study aimed to assess the prognostic value of the primary tumor volumetric parameters obtained from FDG PET/CT first stage for the overall survival (OS) and progression-free survival (PFS) of patients with pancreatic adenocarcinoma and to explore the possible correlation between serum matrix metalloproteinase-2 (MMP-2) and the patients’ characteristics. Methods: Fifty patients with pancreatic adenocarcinoma were subjected to FDG PET/CT scan. The SUVpeak, SUVmax, and the metabolic tumor volume (MTV) were determined, as well as the SUVmean of the liver. Moreover, serum levels of MMP-2 were assessed. Follow-up of the patients was carried out for sixty months with determination of PFS and OS. Results: Peak SUV ≥ 3.9 was significantly correlated with the primary pancreatic lesions’ mean total glycolytic activity of >92 g, and MTV and was directly correlated with mortality. There was a positive correlation between peak SUV ≥ 3.9 and 50% SUVmax threshold > 82. Moreover, there was significant correlation between the total glycolytic activity and the studied clinicopathologic factors, except the age and sex of the patients and ECOG performance status. In addition, FDG uptake and the tumor glycolytic activity were substantially linked with a shorter PFS. Similarly, a strong correlation was found between MTV and PFS. Serum MMP-2 levels showed a significant relationship with the performance status, tumor stage, SUVmax threshold, and the glycolytic activity. Conclusions: Peak SUV, main lesion SUVmax, serum MMP-2, and the tumor glycolytic activity are good predictors of PFS of patients with pancreatic adenocarcinoma. Background and objectives : Pancreatic adenocarcinoma represents one of the common malignancies with a relatively poor prognosis. However, early detection of this type of cancer may prove to be curable. Recent advancements in the radiological techniques might represent a hope for the early diagnosis and prediction of prognosis of pancreatic adenocarcinoma. This study aimed to assess the prognostic value of the primary tumor volumetric parameters obtained from FDG PET/CT first stage for the overall survival (OS) and progression-free survival (PFS) of patients with pancreatic adenocarcinoma and to explore the possible correlation between serum matrix metalloproteinase-2 (MMP-2) and the patients’ characteristics. Methods : Fifty patients with pancreatic adenocarcinoma were subjected to FDG PET/CT scan. The SUVpeak, SUVmax, and the metabolic tumor volume (MTV) were determined, as well as the SUVmean of the liver. Moreover, serum levels of MMP-2 were assessed. Follow-up of the patients was carried out for sixty months with determination of PFS and OS. Results : Peak SUV ≥ 3.9 was significantly correlated with the primary pancreatic lesions’ mean total glycolytic activity of >92 g, and MTV and was directly correlated with mortality. There was a positive correlation between peak SUV ≥ 3.9 and 50% SUVmax threshold > 82. Moreover, there was significant correlation between the total glycolytic activity and the studied clinicopathologic factors, except the age and sex of the patients and ECOG performance status. In addition, FDG uptake and the tumor glycolytic activity were substantially linked with a shorter PFS. Similarly, a strong correlation was found between MTV and PFS. Serum MMP-2 levels showed a significant relationship with the performance status, tumor stage, SUVmax threshold, and the glycolytic activity. Conclusions : Peak SUV, main lesion SUVmax, serum MMP-2, and the tumor glycolytic activity are good predictors of PFS of patients with pancreatic adenocarcinoma. |
Audience | Academic |
Author | Sabry, Nesreen M Salama, Samir A Kabel, Ahmed M Youssef, Amira Magdy, Amr A Mokhtar, Hwaida M Naguib, Tamer M |
AuthorAffiliation | 3 Anesthesia and ICU Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt; tnaguib1eg@yahoo.com (T.M.N.); amrmagdy@med.tanta.edu.eg (A.A.M.) 2 Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt; damirayoussef@yahoo.com 1 Radiodiagnosis Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt; hwaidamahmoudhm18@gmail.com 5 Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta 31527, Egypt 6 Clinical Oncology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt; nesreensabry1eg@yahoo.com 4 Division of Biochemistry, Department of Pharmacology, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia; s.salama@tu.edu.sa |
AuthorAffiliation_xml | – name: 1 Radiodiagnosis Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt; hwaidamahmoudhm18@gmail.com – name: 3 Anesthesia and ICU Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt; tnaguib1eg@yahoo.com (T.M.N.); amrmagdy@med.tanta.edu.eg (A.A.M.) – name: 4 Division of Biochemistry, Department of Pharmacology, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia; s.salama@tu.edu.sa – name: 2 Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt; damirayoussef@yahoo.com – name: 5 Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta 31527, Egypt – name: 6 Clinical Oncology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt; nesreensabry1eg@yahoo.com |
Author_xml | – sequence: 1 givenname: Hwaida M surname: Mokhtar fullname: Mokhtar, Hwaida M organization: Radiodiagnosis Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt – sequence: 2 givenname: Amira surname: Youssef fullname: Youssef, Amira organization: Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt – sequence: 3 givenname: Tamer M surname: Naguib fullname: Naguib, Tamer M organization: Anesthesia and ICU Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt – sequence: 4 givenname: Amr A surname: Magdy fullname: Magdy, Amr A organization: Anesthesia and ICU Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt – sequence: 5 givenname: Samir A surname: Salama fullname: Salama, Samir A organization: Division of Biochemistry, Department of Pharmacology, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia – sequence: 6 givenname: Ahmed M orcidid: 0000-0002-5101-8011 surname: Kabel fullname: Kabel, Ahmed M organization: Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta 31527, Egypt – sequence: 7 givenname: Nesreen M orcidid: 0000-0001-5458-3422 surname: Sabry fullname: Sabry, Nesreen M organization: Clinical Oncology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt |
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Snippet | Background and objectives: Pancreatic adenocarcinoma represents one of the common malignancies with a relatively poor prognosis. However, early detection of... Background and objectives : Pancreatic adenocarcinoma represents one of the common malignancies with a relatively poor prognosis. However, early detection of... |
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SubjectTerms | Adenocarcinoma - diagnostic imaging Adenocarcinoma - pathology Antibodies Antigens Cancer therapies Chemotherapy CT imaging Diagnosis Enzymes Fluorodeoxyglucose F18 Humans Laboratories Matrix Metalloproteinase 2 matrix metalloproteinases Medical imaging Medical prognosis Mortality pancreatic adenocarcinoma Pancreatic cancer Pancreatic Neoplasms Pancreatic Neoplasms - diagnostic imaging Pancreatic Neoplasms - pathology Patients PET imaging PET/CT scan Positron Emission Tomography Computed Tomography - methods Prognosis Prospective Studies Radiation therapy Radiopharmaceuticals Retrospective Studies Tomography Tumors |
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Title | The Significance of FDG PET/CT-Derived Parameters in Determining Prognosis of Cases with Pancreatic Adenocarcinoma: A Prospective Study |
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