Purinergic system dysfunctions in subjects with bipolar disorder: A comparative cross-sectional study

• Published in: Comprehensive psychiatry Vol. 73; pp. 1 - 6
• Main Authors: Bartoli, Francesco, Crocamo, Cristina, Dakanalis, Antonios, Brosio, Enrico, Miotto, Alessio, Capuzzi, Enrico, Clerici, Massimo, Carrà, Giuseppe
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2017; Elsevier Limited
• Subjects: Adenosine; Adolescent; Adult; Age; Aged; Bilirubin - blood; Biomarkers - blood; Bipolar disorder; Bipolar Disorder - blood; Case-Control Studies; Cholesterol; Creatinine - blood; Cross-Sectional Studies; Depressive Disorder, Major - blood; Female; Funding; Gender; Hospitals; Humans; Hypotheses; Male; Mental depression; Metabolism; Middle Aged; Nervous system; Oxidative stress; Psychiatry; Serum Albumin; Studies; Triglycerides; Uric acid; Uric Acid - blood; Variables; Variance analysis; Young Adult
• ISSN: 0010-440X; 1532-8384; 1532-8384
• DOI: 10.1016/j.comppsych.2016.09.011

Subjects with bipolar mania may have increased uric acid levels, based on a purinergic system dysfunction with reduced neurotransmission of adenosine. We investigated whether there were differences in uric acid levels between individuals with bipolar disorder (in manic or depressive phases) and thos...