Increased expression of cannabinoid receptor 1 in the nucleus accumbens core in a rat model with morphine withdrawal

• Published in: Brain research Vol. 1531; pp. 102 - 112
• Main Authors: Yuan, Wei-Xin, Heng, Li-Jun, Ma, Jie, Wang, Xing-Qin, Qu, Li-Juan, Duan, Li, Kang, Jun-Jun, Chen, Liang-Wei, Gao, Guo-Dong
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 19.09.2013; Elsevier
• Subjects: Analgesics; animal models; Animals; antagonists; Biological and medical sciences; brain; Cannabinoid receptor 1; Cannabinoid system; cannabinoids; Conditioned place preference; Disease Models, Animal; drug abuse; drug therapy; electron microscopy; fluorescence; fluorescent antibody technique; Male; Medical sciences; morphine; Morphine Dependence - metabolism; Morphine withdrawal; Neurology; Neuropharmacology; Nucleus Accumbens - metabolism; Nucleus accumbens core; Pharmacology. Drug treatments; Psychodysleptics: hallucinogen; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Cannabinoid, CB1 - biosynthesis; relapse; Rimonabant; Substance Withdrawal Syndrome - metabolism; Up-Regulation - physiology; Nucleus accumbens core; Cannabinoid receptor 1; Conditioned place preference; Morphine withdrawal; Rimonabant; Cannabinoid system; Animal model; Rat; Rodentia; Central nervous system; Opiates; Morphine; Basal ganglion; Narcotic analgesic; Cannabinoid; Encephalon; Nucleus accumbens; Vertebrata; Mammalia; Animal; Cannabinoid receptor

Abstract Relapse is a major clinical problem and remains a major challenge in the treatment of drug addiction. There is strong evidence that the endocannabinoid system of the nucleus accumben core (NAcc) is involved in drug-seeking behavior, as well as in the mechanisms that underlie relapse to drug...