Advancements in the mechanistic understanding of the copper-catalyzed azide–alkyne cycloaddition

• Published in: Beilstein journal of organic chemistry Vol. 9; no. 1; pp. 2715 - 2750
• Main Authors: Berg, Regina, Straub, Bernd F
• Format: Journal Article
• Language: English
• Published: Germany Beilstein-Institut 02.12.2013
• Subjects: alkyne; azide; Chemistry; Click; copper; CuAAC; DFT study; Huisgen–Meldal–Sharpless cycloaddition; kinetics; reaction mechanism; Review; reaction mechanism; CuAAC; Huisgen–Meldal–Sharpless cycloaddition; copper; Click; DFT study; alkyne; kinetics; azide

The copper-catalyzed azide–alkyne cycloaddition (CuAAC) is one of the most broadly applicable and easy-to-handle reactions in the arsenal of organic chemistry. However, the mechanistic understanding of this reaction has lagged behind the plethora of its applications for a long time. As reagent mixtu...