Antiandrogen Flutamide Protects Male Mice From Androgen-Dependent Toxicity in Three Models of Spinal Bulbar Muscular Atrophy - Renier, Kayla J.; Troxell-Smith, Sandra M.; Johansen, Jamie A.; Katsuno, Masahisa; Adachi, Hiroaki; Sobue, Gen; Chua, Jason P.; Sun Kim, Hong; Lieberman, Andrew P.; Breedlove, S. Marc; Jordan, Cynthia L. (Endocrinology (Philadelphia), 2014)
Keywords: Androgen Antagonists - pharmacology; Androgen receptors; Androgens; Androgens - metabolism; Animal models; Animals; Antagonists; Atrophy; Blotting, Western; Bulbo-Spinal Atrophy, X-Linked - drug therapy; Bulbo-Spinal Atrophy, X-Linked - genetics; Bulbo-Spinal Atrophy, X-Linked - metabolism; Disease Models, Animal; Flutamide; Flutamide - pharmacology; Life span; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscles; Neurodegenerative diseases; Neuroendocrinology; Orchiectomy; Peptides - genetics; Polyglutamine diseases; Receptors, Androgen - genetics; Receptors, Androgen - metabolism; Spinal and bulbar muscular atrophy; Survival Analysis; Time Factors; Toxicity; Transgenic mice; Treatment Outcome; Trinucleotide repeat diseases; Trinucleotide Repeat Expansion - genetics