Cortical Bcl-2 protein expression and apoptotic regulation in schizophrenia

• Published in: Biological psychiatry (1969) Vol. 48; no. 7; pp. 641 - 650
• Main Authors: Jarskog, L.Fredrik, Gilmore, John H, Selinger, Elzbieta S, Lieberman, Jeffrey A
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.10.2000; Elsevier Science
• Subjects: Adult; Adult and adolescent clinical studies; apoptosis; Apoptosis - physiology; Bcl-2; Biological and medical sciences; Bipolar Disorder - pathology; Blotting, Western; Depressive Disorder, Major - pathology; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Medical sciences; Middle Aged; neurodegeneration; neurodevelopment; neuroprotection; Proto-Oncogene Proteins c-bcl-2 - analysis; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Reference Values; Schizophrenia; Schizophrenia - pathology; Temporal Lobe - pathology; Bcl-2; neurodegeneration; apoptosis; schizophrenia; neurodevelopment; neuroprotection; Human; Cerebral cortex; Neuroleptic; Pathogenesis; Central nervous system; Schizophrenia; Temporal cortex; Gene expression; Psychosis; Chemotherapy; Antipsychotic; Brain (vertebrata); Apoptosis

Background: The etiology of schizophrenia remains unknown; however, a role for apoptosis has been hypothesized. Bcl-2 is a potent inhibitor of apoptosis and also exerts neurotrophic activity in the central nervous system (CNS). Bcl-2 expression is increased in the CNS of several neurodegenerative di...