IL-17RB+ granulocytes are associated with airflow obstruction in asthma

• Published in: Annals of allergy, asthma, & immunology Vol. 117; no. 6; pp. 674 - 679
• Main Authors: Li, Lin, MD, Lukacs, Nicholas W., PhD, Schaller, Matthew A., PhD, Petersen, Bryan, MD, PhD, Baptist, Alan P., MD, MPH
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2016
• Subjects: Adult; Airway Obstruction - immunology; Airway Obstruction - metabolism; Airway Obstruction - pathology; Allergy and Immunology; Asthma - immunology; Asthma - metabolism; Asthma - pathology; Asthma - physiopathology; Biomarkers; Case-Control Studies; Eosinophils; Female; Fluorescent Antibody Technique; Forced Expiratory Volume; Granulocytes - immunology; Granulocytes - metabolism; Humans; Immunophenotyping; Leukocyte Count; Male; Middle Aged; Phenotype; Receptors, Interleukin - metabolism; Respiratory Function Tests

Abstract Background Interleukin (IL)-25 (IL-17E) is a proinflammatory cytokine that plays an important role in the T-helper type 2 cell pathway. The effects of IL-25 are mediated by its specific receptor, IL-17RB. Previous studies have defined an IL-17RB+ granulocyte population known as type 2 myelo...