Cartilage responses to a novel triaxial mechanostimulatory culture system

• Published in: Journal of biomechanics Vol. 37; no. 5; pp. 689 - 695
• Main Authors: Heiner, Anneliese D., Martin, James A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.05.2004; Elsevier Limited
• Subjects: Arthritis; Biosynthesis; Cartilage; Cartilage mechanics; Cartilage, Articular - physiopathology; Cell Culture Techniques - methods; Cells, Cultured; Compressive Strength; Extracellular Matrix; Gene expression; Humans; Hypotheses; Load; Mechanical stress; Mechanotransduction, Cellular; Nitric oxide; Osteoarthritis; Osteoarthritis, Knee - physiopathology; Physical Stimulation - instrumentation; Physical Stimulation - methods; Pressure vessels; Proteoglycan synthesis; Proteoglycans - metabolism; Shear Strength; Shear stress; Soil mechanics; Stress state; Stress, Mechanical; Tissue culture; Weight-Bearing; Tissue culture; Cartilage mechanics; Proteoglycan synthesis; Mechanical stress; Osteoarthritis

We have developed a novel mechanically active cartilage culture device capable of modulating the interplay between compression and shear, at physiologic stress levels (2–5 MPa). This triaxial compression culture system subjects cylindrical cartilage explants to pulsatile axial compression from plate...