Hepatitis B vaccines: assessment of the seroprotective efficacy of two recombinant DNA vaccines

• Published in: Clinical therapeutics Vol. 23; no. 3; pp. 392 - 403
• Main Authors: Coates, Toby, Wilson, Rosamund, Patrick, Guy, André, Francis, Watson, Virginia
• Format: Journal Article
• Language: English
• Published: Belle Mead, NJ EM Inc USA 01.03.2001; Excerpta Medica
• Subjects: Adolescent; Adult; Aged; analysis; Biological and medical sciences; Child; Child, Preschool; clinical study review; Female; Hepatitis B - prevention & control; hepatitis B vaccine; Hepatitis B Vaccines - immunology; Humans; Infant; Male; Medical sciences; Middle Aged; Miscellaneous; Pharmacology. Drug treatments; seroprotection or seroprotective response rates; vaccination program; Vaccines, DNA - immunology; Vaccines, Synthetic - immunology; standards; vaccination program; clinical study review; analysis; hepatitis B vaccine; seroprotection or seroprotective response rates; Infection; Human; Viral hepatitis B; Prevention; Immunogenicity; Viral disease; Vaccination; Digestive diseases; Hepatic disease; Vaccine; Review; Genetic vaccine

Background: In universal vaccination programs, when there is no postvaccination serologic assessment of response, there must be confidence that the vaccines used provide a high degree of seroprotection. Objective: This parallel analysis of 2 recombinant hepatitis B vaccines (Engerix B ® and Recombiv...