Quercetin decreases the activity of matrix metalloproteinase-2 and ameliorates vascular remodeling in renovascular hypertension

• Published in: Atherosclerosis Vol. 270; pp. 146 - 153
• Main Authors: Pereira, Sherliane C., Parente, Juliana M., Belo, Vanessa A., Mendes, Atlante S., Gonzaga, Natália A., do Vale, Gabriel T., Ceron, Carla S., Tanus-Santos, José Eduardo, Tirapelli, Carlos R., Castro, Michele M.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.03.2018
• Subjects: Animals; Antioxidant; Antioxidants - pharmacology; Aorta - drug effects; Aorta - enzymology; Aorta - pathology; Aorta - physiopathology; Disease Models, Animal; Focal Adhesion Kinase 1 - metabolism; Hypertension; Hypertension, Renovascular - drug therapy; Hypertension, Renovascular - enzymology; Hypertension, Renovascular - pathology; Hypertension, Renovascular - physiopathology; Male; Matrix metalloproteinase; Matrix Metalloproteinase 2 - metabolism; Oxidative stress; Oxidative Stress - drug effects; Phosphorylation; Quercetin - pharmacology; Rats, Wistar; Reactive Oxygen Species - metabolism; Signal Transduction - drug effects; Vascular remodeling; Vascular Remodeling - drug effects; Vascular remodeling; Hypertension; Oxidative stress; Matrix metalloproteinase; Antioxidant

Increased activity of matrix metalloproteinase (MMP)-2 is observed in aortas of different models of hypertension, and its activation is directly mediated by oxidative stress. As quercetin is an important flavonoid with significant antioxidant effects, the hypothesis here is that quercetin will reduc...