Quercetin decreases the activity of matrix metalloproteinase-2 and ameliorates vascular remodeling in renovascular hypertension
Increased activity of matrix metalloproteinase (MMP)-2 is observed in aortas of different models of hypertension, and its activation is directly mediated by oxidative stress. As quercetin is an important flavonoid with significant antioxidant effects, the hypothesis here is that quercetin will reduc...
Saved in:
Published in | Atherosclerosis Vol. 270; pp. 146 - 153 |
---|---|
Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Ireland
Elsevier B.V
01.03.2018
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Increased activity of matrix metalloproteinase (MMP)-2 is observed in aortas of different models of hypertension, and its activation is directly mediated by oxidative stress. As quercetin is an important flavonoid with significant antioxidant effects, the hypothesis here is that quercetin will reduce increased MMP-2 activity by decreasing oxidative stress in aortas of hypertensive rats and then ameliorate hypertension-induced vascular remodeling.
Male two-kidney one-clip (2K1C) hypertensive Wistar rats and controls were treated with quercetin (10 mg/kg/day) or its vehicle for three weeks by gavage. Rats were then analyzed at five weeks of hypertension. Systolic blood pressure (SBP) was determined by tail-cuff plethysmography. Aortas were used to determine MMP activity by in situ zymography and reactive oxygen species (ROS) levels by dihydroethidium. Western blot was performed to detect focal adhesion kinase (FAK) and phosphorylated-FAK levels.
SBP was increased in 2K1C rats and only a borderline reduction in SBP was observed after treating 2K1C rats with quercetin. Cross-sectional area and the number of vascular smooth muscle cells were significantly increased in aortas of hypertensive rats, and quercetin reduced them. Quercetin reduced ROS levels in aortas of 2K1C rats and the increased activity of gelatinases in situ. However, quercetin did not affect the levels of tissue inhibitor of MMP (TIMP)-2 and did not interfere with FAK and p-FAK levels in aortas of hypertensive rats. Furthermore, different concentrations of quercetin did not directly reduce the activity of human recombinant MMP-2 in vitro.
Quercetin reduces hypertension-induced vascular remodeling, oxidative stress and MMP-2 activity in aortas.
•Quercetin decreased the number of vascular smooth muscle cells and increased aortic cross-sectional area in hypertension.•Quercetin reduces NAD(P)H oxidase activity and superoxide anion in hypertensive rats.•Quercetin reduced MMP-2 activity in aorta of hypertensive rats and its effect in hyperplasia of vascular smooth muscle cells.•Quercetin did not significantly reduce systolic blood pressure in hypertension although it ameliorated vascular remodeling. |
---|---|
AbstractList | BACKGROUND AND AIMSIncreased activity of matrix metalloproteinase (MMP)-2 is observed in aortas of different models of hypertension, and its activation is directly mediated by oxidative stress. As quercetin is an important flavonoid with significant antioxidant effects, the hypothesis here is that quercetin will reduce increased MMP-2 activity by decreasing oxidative stress in aortas of hypertensive rats and then ameliorate hypertension-induced vascular remodeling.METHODSMale two-kidney one-clip (2K1C) hypertensive Wistar rats and controls were treated with quercetin (10 mg/kg/day) or its vehicle for three weeks by gavage. Rats were then analyzed at five weeks of hypertension. Systolic blood pressure (SBP) was determined by tail-cuff plethysmography. Aortas were used to determine MMP activity by in situ zymography and reactive oxygen species (ROS) levels by dihydroethidium. Western blot was performed to detect focal adhesion kinase (FAK) and phosphorylated-FAK levels.RESULTSSBP was increased in 2K1C rats and only a borderline reduction in SBP was observed after treating 2K1C rats with quercetin. Cross-sectional area and the number of vascular smooth muscle cells were significantly increased in aortas of hypertensive rats, and quercetin reduced them. Quercetin reduced ROS levels in aortas of 2K1C rats and the increased activity of gelatinases in situ. However, quercetin did not affect the levels of tissue inhibitor of MMP (TIMP)-2 and did not interfere with FAK and p-FAK levels in aortas of hypertensive rats. Furthermore, different concentrations of quercetin did not directly reduce the activity of human recombinant MMP-2 in vitro.CONCLUSIONSQuercetin reduces hypertension-induced vascular remodeling, oxidative stress and MMP-2 activity in aortas. Increased activity of matrix metalloproteinase (MMP)-2 is observed in aortas of different models of hypertension, and its activation is directly mediated by oxidative stress. As quercetin is an important flavonoid with significant antioxidant effects, the hypothesis here is that quercetin will reduce increased MMP-2 activity by decreasing oxidative stress in aortas of hypertensive rats and then ameliorate hypertension-induced vascular remodeling. Male two-kidney one-clip (2K1C) hypertensive Wistar rats and controls were treated with quercetin (10 mg/kg/day) or its vehicle for three weeks by gavage. Rats were then analyzed at five weeks of hypertension. Systolic blood pressure (SBP) was determined by tail-cuff plethysmography. Aortas were used to determine MMP activity by in situ zymography and reactive oxygen species (ROS) levels by dihydroethidium. Western blot was performed to detect focal adhesion kinase (FAK) and phosphorylated-FAK levels. SBP was increased in 2K1C rats and only a borderline reduction in SBP was observed after treating 2K1C rats with quercetin. Cross-sectional area and the number of vascular smooth muscle cells were significantly increased in aortas of hypertensive rats, and quercetin reduced them. Quercetin reduced ROS levels in aortas of 2K1C rats and the increased activity of gelatinases in situ. However, quercetin did not affect the levels of tissue inhibitor of MMP (TIMP)-2 and did not interfere with FAK and p-FAK levels in aortas of hypertensive rats. Furthermore, different concentrations of quercetin did not directly reduce the activity of human recombinant MMP-2 in vitro. Quercetin reduces hypertension-induced vascular remodeling, oxidative stress and MMP-2 activity in aortas. •Quercetin decreased the number of vascular smooth muscle cells and increased aortic cross-sectional area in hypertension.•Quercetin reduces NAD(P)H oxidase activity and superoxide anion in hypertensive rats.•Quercetin reduced MMP-2 activity in aorta of hypertensive rats and its effect in hyperplasia of vascular smooth muscle cells.•Quercetin did not significantly reduce systolic blood pressure in hypertension although it ameliorated vascular remodeling. Increased activity of matrix metalloproteinase (MMP)-2 is observed in aortas of different models of hypertension, and its activation is directly mediated by oxidative stress. As quercetin is an important flavonoid with significant antioxidant effects, the hypothesis here is that quercetin will reduce increased MMP-2 activity by decreasing oxidative stress in aortas of hypertensive rats and then ameliorate hypertension-induced vascular remodeling. Male two-kidney one-clip (2K1C) hypertensive Wistar rats and controls were treated with quercetin (10 mg/kg/day) or its vehicle for three weeks by gavage. Rats were then analyzed at five weeks of hypertension. Systolic blood pressure (SBP) was determined by tail-cuff plethysmography. Aortas were used to determine MMP activity by in situ zymography and reactive oxygen species (ROS) levels by dihydroethidium. Western blot was performed to detect focal adhesion kinase (FAK) and phosphorylated-FAK levels. SBP was increased in 2K1C rats and only a borderline reduction in SBP was observed after treating 2K1C rats with quercetin. Cross-sectional area and the number of vascular smooth muscle cells were significantly increased in aortas of hypertensive rats, and quercetin reduced them. Quercetin reduced ROS levels in aortas of 2K1C rats and the increased activity of gelatinases in situ. However, quercetin did not affect the levels of tissue inhibitor of MMP (TIMP)-2 and did not interfere with FAK and p-FAK levels in aortas of hypertensive rats. Furthermore, different concentrations of quercetin did not directly reduce the activity of human recombinant MMP-2 in vitro. Quercetin reduces hypertension-induced vascular remodeling, oxidative stress and MMP-2 activity in aortas. |
Author | Belo, Vanessa A. do Vale, Gabriel T. Gonzaga, Natália A. Ceron, Carla S. Parente, Juliana M. Mendes, Atlante S. Castro, Michele M. Pereira, Sherliane C. Tirapelli, Carlos R. Tanus-Santos, José Eduardo |
Author_xml | – sequence: 1 givenname: Sherliane C. surname: Pereira fullname: Pereira, Sherliane C. organization: Department of Pharmacology, Ribeirao Preto Medical School, University of Sao, Paulo, Av. Bandeirantes, 3900, 14049-900, Ribeirao Preto, SP, Brazil – sequence: 2 givenname: Juliana M. surname: Parente fullname: Parente, Juliana M. organization: Department of Pharmacology, Ribeirao Preto Medical School, University of Sao, Paulo, Av. Bandeirantes, 3900, 14049-900, Ribeirao Preto, SP, Brazil – sequence: 3 givenname: Vanessa A. surname: Belo fullname: Belo, Vanessa A. organization: Department of Pharmacology, Ribeirao Preto Medical School, University of Sao, Paulo, Av. Bandeirantes, 3900, 14049-900, Ribeirao Preto, SP, Brazil – sequence: 4 givenname: Atlante S. surname: Mendes fullname: Mendes, Atlante S. organization: Department of Pharmacology, Ribeirao Preto Medical School, University of Sao, Paulo, Av. Bandeirantes, 3900, 14049-900, Ribeirao Preto, SP, Brazil – sequence: 5 givenname: Natália A. surname: Gonzaga fullname: Gonzaga, Natália A. organization: Department of Pharmacology, Ribeirao Preto Medical School, University of Sao, Paulo, Av. Bandeirantes, 3900, 14049-900, Ribeirao Preto, SP, Brazil – sequence: 6 givenname: Gabriel T. surname: do Vale fullname: do Vale, Gabriel T. organization: Department of Pharmacology, Ribeirao Preto Medical School, University of Sao, Paulo, Av. Bandeirantes, 3900, 14049-900, Ribeirao Preto, SP, Brazil – sequence: 7 givenname: Carla S. surname: Ceron fullname: Ceron, Carla S. organization: Department of Pharmacology, Ribeirao Preto Medical School, University of Sao, Paulo, Av. Bandeirantes, 3900, 14049-900, Ribeirao Preto, SP, Brazil – sequence: 8 givenname: José Eduardo surname: Tanus-Santos fullname: Tanus-Santos, José Eduardo organization: Department of Pharmacology, Ribeirao Preto Medical School, University of Sao, Paulo, Av. Bandeirantes, 3900, 14049-900, Ribeirao Preto, SP, Brazil – sequence: 9 givenname: Carlos R. surname: Tirapelli fullname: Tirapelli, Carlos R. organization: Department of Pharmacology, Ribeirao Preto Medical School, University of Sao, Paulo, Av. Bandeirantes, 3900, 14049-900, Ribeirao Preto, SP, Brazil – sequence: 10 givenname: Michele M. surname: Castro fullname: Castro, Michele M. email: castro@fmrp.usp.br organization: Department of Pharmacology, Ribeirao Preto Medical School, University of Sao, Paulo, Av. Bandeirantes, 3900, 14049-900, Ribeirao Preto, SP, Brazil |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29425960$$D View this record in MEDLINE/PubMed |
BookMark | eNqNkUFv1DAQhS1URLeFv4B8QeKSMOPEG-fAAVVQkCohJDhbjjOhXiX2Yjur7om_jldbeuDExZbs782bmXfFLnzwxNgbhBoBt-92tcn3FEOy8-l0qRaAqgasocFnbIOq6ytsVXvBNgACqx4lXLKrlHYA0HaoXrBL0bdC9lvYsN_fVoqWsvN8JBvJJEq8GHBjszu4fORh4ovJ0T3whbKZ57CPIZPzhawEN37kZqHZhWhykR5MsutsIo-0hLG8-5-81I7kw9PX_XFPMZNPLviX7Plk5kSvHu9r9uPTx-83n6u7r7dfbj7cVVYi5EqBlNAKRRJENzTYY9ugVFPXN2qkyYIZ5XYYJDaDnboy_mAM0NiDVMpO1jbX7O25bun-10op68UlS_NsPIU1aQGAsBW9lAV9f0Zt2W-KNOl9dIuJR42gTxnonf4nA33KQAPqkkHRv360WoeFxif136UX4PYMUBn44CjqZB15S6OLZLMeg_tPqz8Go6eH |
CitedBy_id | crossref_primary_10_1016_j_physbeh_2020_113293 crossref_primary_10_3390_biomedicines12040794 crossref_primary_10_1016_j_atherosclerosis_2018_03_016 crossref_primary_10_1055_a_1712_7978 crossref_primary_10_3390_biom11040585 crossref_primary_10_3390_molecules28052387 crossref_primary_10_1016_j_vph_2019_03_004 crossref_primary_10_3389_fchem_2024_1356458 crossref_primary_10_1016_j_ejphar_2018_10_017 crossref_primary_10_1016_j_lfs_2019_117153 crossref_primary_10_1155_2018_7421489 crossref_primary_10_2174_1573402118666221003095317 crossref_primary_10_3390_molecules27217222 crossref_primary_10_1007_s12264_019_00460_y crossref_primary_10_1016_j_atherosclerosis_2018_02_033 crossref_primary_10_1042_BSR20180525 crossref_primary_10_18705_2311_4495_2023_10_3_183_208 crossref_primary_10_3390_ph15081019 crossref_primary_10_14218_JERP_2020_00008 crossref_primary_10_1039_D1FO04381A crossref_primary_10_1016_j_jtcms_2022_06_007 crossref_primary_10_1155_2019_5470470 crossref_primary_10_3233_MNM_220001 crossref_primary_10_1016_j_psj_2023_103246 crossref_primary_10_1038_s41598_022_13513_6 crossref_primary_10_1007_s00424_020_02461_7 crossref_primary_10_1016_j_tifs_2023_07_008 crossref_primary_10_3390_ph14020086 crossref_primary_10_1007_s00210_022_02349_6 crossref_primary_10_3390_ijms21197226 crossref_primary_10_1155_2023_8459095 crossref_primary_10_15406_ppij_2020_08_00285 crossref_primary_10_1080_10641963_2022_2101658 crossref_primary_10_1016_j_bmc_2022_116854 crossref_primary_10_1016_j_phymed_2024_155865 crossref_primary_10_2174_1573402116666200510011356 crossref_primary_10_3390_ijms21051585 crossref_primary_10_1016_j_archoralbio_2023_105703 crossref_primary_10_1016_j_jff_2021_104868 crossref_primary_10_3389_fcvm_2023_1203713 crossref_primary_10_3390_ani13010005 crossref_primary_10_1016_j_vph_2018_10_002 crossref_primary_10_37871_jbres1208 crossref_primary_10_3389_fphar_2022_1002363 crossref_primary_10_2174_1568009621666210525152802 crossref_primary_10_1155_2020_3860213 |
Cites_doi | 10.1016/j.yjmcc.2009.09.018 10.1093/jn/137.11.2405 10.1161/01.HYP.0000154680.44184.01 10.1016/j.atherosclerosis.2015.09.026 10.1093/cvr/cvx115 10.1016/0140-6736(93)92876-U 10.1016/j.matbio.2012.01.009 10.1159/000441621 10.1152/physiol.00029.2008 10.1038/hr.2010.201 10.1089/ars.2013.5607 10.1016/S0006-291X(02)00407-2 10.2174/1570161054368643 10.1007/s13105-016-0519-z 10.1016/j.freeradbiomed.2013.06.033 10.1016/j.phrs.2011.05.005 10.1016/j.bcp.2004.02.023 10.1097/00004872-200111000-00006 10.1161/01.CIR.0000093661.90582.c4 10.1007/s00210-010-0546-1 10.1016/j.cardiores.2007.02.008 10.1016/j.atherosclerosis.2011.04.023 10.1161/01.RES.0000077044.60138.7C 10.1152/ajplung.00287.2004 10.1016/j.taap.2012.08.029 10.1016/j.freeradbiomed.2009.02.011 10.1097/01.hjh.0000198029.22472.d9 10.1016/j.matbio.2009.11.005 10.1038/sj.bjp.0704064 10.1016/j.niox.2007.12.002 10.1172/JCI119076 10.1016/j.atherosclerosis.2007.10.011 10.1161/ATVBAHA.111.242685 10.1016/j.cca.2016.08.002 10.3892/mmr.2013.1846 10.1016/j.cardiores.2005.08.002 10.1152/ajpheart.01066.2010 10.1016/S0006-291X(03)00091-3 10.3390/ijms16048168 10.1016/0891-5849(95)02227-9 10.1016/j.ijcard.2011.08.060 10.1016/j.bcp.2008.11.004 |
ContentType | Journal Article |
Copyright | 2018 Elsevier B.V. Copyright © 2018 Elsevier B.V. All rights reserved. |
Copyright_xml | – notice: 2018 Elsevier B.V. – notice: Copyright © 2018 Elsevier B.V. All rights reserved. |
DBID | 6I. AAFTH CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1016/j.atherosclerosis.2018.01.031 |
DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1879-1484 |
EndPage | 153 |
ExternalDocumentID | 10_1016_j_atherosclerosis_2018_01_031 29425960 S0021915018300315 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | --- --K --M .1- .55 .FO .GJ .~1 0R~ 0SF 1B1 1P~ 1RT 1~. 1~5 23N 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 6I. 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAFTH AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAXUO ABBQC ABFNM ABJNI ABLJU ABLVK ABMAC ABMZM ABOCM ABXDB ABYKQ ACDAQ ACGFS ACIUM ACRLP ADBBV ADEZE AEBSH AEKER AENEX AEVXI AEXQZ AFCTW AFFNX AFKWA AFRHN AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AHPSJ AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY AJUYK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEB HMK HMO HVGLF HZ~ IHE J1W J5H K-O KOM L7B LCYCR M27 M41 MO0 N9A NCXOZ O-L O9- OAUVE OA~ OK1 OL0 OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAE SCC SDF SDG SDP SEL SES SEW SPCBC SSH SSZ T5K WUQ X7M Z5R ZA5 ZGI ZXP ~G- ~KM AAXKI AFJKZ AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
ID | FETCH-LOGICAL-c510t-80550428e5027b319143158f7938defc0ad56bb513bcf7148baa0ed90588cfcc3 |
IEDL.DBID | AIKHN |
ISSN | 0021-9150 |
IngestDate | Sun Sep 29 07:36:33 EDT 2024 Thu Sep 26 18:21:36 EDT 2024 Wed Oct 16 00:49:56 EDT 2024 Fri Feb 23 02:28:36 EST 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | Vascular remodeling Hypertension Oxidative stress Matrix metalloproteinase Antioxidant |
Language | English |
License | http://www.elsevier.com/open-access/userlicense/1.0 Copyright © 2018 Elsevier B.V. All rights reserved. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c510t-80550428e5027b319143158f7938defc0ad56bb513bcf7148baa0ed90588cfcc3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S0021915018300315 |
PMID | 29425960 |
PQID | 2001062955 |
PQPubID | 23479 |
PageCount | 8 |
ParticipantIDs | proquest_miscellaneous_2001062955 crossref_primary_10_1016_j_atherosclerosis_2018_01_031 pubmed_primary_29425960 elsevier_sciencedirect_doi_10_1016_j_atherosclerosis_2018_01_031 |
PublicationCentury | 2000 |
PublicationDate | March 2018 2018-03-00 20180301 |
PublicationDateYYYYMMDD | 2018-03-01 |
PublicationDate_xml | – month: 03 year: 2018 text: March 2018 |
PublicationDecade | 2010 |
PublicationPlace | Ireland |
PublicationPlace_xml | – name: Ireland |
PublicationTitle | Atherosclerosis |
PublicationTitleAlternate | Atherosclerosis |
PublicationYear | 2018 |
Publisher | Elsevier B.V |
Publisher_xml | – name: Elsevier B.V |
References | Rodrigues, Lunardi, Lima (bib11) 2008; 18 Wang, Cheng, Li (bib29) 2014; 9 Dao, Lemay, de Champlain (bib32) 2001; 19 Montenegro, Neto-Neves, Dias-Junior (bib28) 2010; 382 Yogi, Callera, Mecawi (bib33) 2012; 264 Touyz, Briones (bib1) 2011; 34 Lee, Huang, Hwang (bib37) 2004; 67 Ceron, Rizzi, Guimaraes (bib39) 2013; 65 Griendling, FitzGerald (bib2) 2003; 108 Barhoumi, Fraulob-Aquino, Mian (bib34) 2017; 113 Ceron, Rizzi, Guimaraes (bib43) 2012; 31 Konior, Schramm, Czesnikiewicz-Guzik (bib3) 2014; 20 Escobales, Crespo (bib13) 2005; 3 Ali, Mungai, Schumacker (bib9) 2006; 291 Castro, Rizzi, Figueiredo-Lopes (bib18) 2008; 198 Hertog, Feskens, Hollman (bib40) 1993; 342 Castro, Rizzi, Prado (bib19) 2010; 29 Ruiz-Ortega, Rodriguez-Vita, Sanchez-Lopez (bib42) 2007; 74 Navarro, de Gouveia, Rocha-Penha (bib31) 2016; 461 Yoshizumi, Tsuchiya, Suzaki (bib5) 2002; 293 Kyaw, Yoshizumi, Tsuchiya (bib4) 2004; 25 Moraes, Frony, Dias (bib10) 2015; 243 Viappiani, Nicolescu, Holt (bib16) 2009; 77 Rice-Evans, Miller, Paganga (bib27) 1996; 20 Castro, Cena, Cho (bib45) 2012; 32 Martinez-Lemus, Hill, Meininger (bib22) 2009; 24 Edwards, Lyon, Litwin (bib35) 2007; 137 Simplicio, do Vale, Gonzaga (bib38) 2017; 73 Bartekova, Simoncikova, Fogarassyova (bib30) 2015; 16 Castro, Rizzi, Rodrigues (bib12) 2009; 46 Martinez-Lemus, Zhao, Galinanes (bib21) 2011; 300 Newby (bib41) 2006; 69 Moon, Cho, Jung (bib7) 2003; 301 Grote, Flach, Luchtefeld (bib14) 2003; 92 Belo, Guimaraes, Castro (bib17) 2015; 52 Lemarie, Tharaux, Lehoux (bib24) 2010; 48 Castro, Kandasamy, Youssef (bib44) 2011; 64 Kleemann, Verschuren, Morrison (bib8) 2011; 218 Bouvet, Gilbert, Girardot (bib20) 2005; 45 Rizzi, Castro, Ceron (bib23) 2013; 165 Yan, Zhang, Wang (bib6) 2013; 8 Rajagopalan, Meng, Ramasamy (bib15) 1996; 98 Sanchez, Galisteo, Vera (bib26) 2006; 24 Serban, Sahebkar, Zanchetti (bib25) 2016 Duarte, Perez-Palencia, Vargas (bib36) 2001; 133 Kyaw (10.1016/j.atherosclerosis.2018.01.031_bib4) 2004; 25 Castro (10.1016/j.atherosclerosis.2018.01.031_bib19) 2010; 29 Lemarie (10.1016/j.atherosclerosis.2018.01.031_bib24) 2010; 48 Ruiz-Ortega (10.1016/j.atherosclerosis.2018.01.031_bib42) 2007; 74 Serban (10.1016/j.atherosclerosis.2018.01.031_bib25) 2016 Bartekova (10.1016/j.atherosclerosis.2018.01.031_bib30) 2015; 16 Wang (10.1016/j.atherosclerosis.2018.01.031_bib29) 2014; 9 Belo (10.1016/j.atherosclerosis.2018.01.031_bib17) 2015; 52 Rajagopalan (10.1016/j.atherosclerosis.2018.01.031_bib15) 1996; 98 Konior (10.1016/j.atherosclerosis.2018.01.031_bib3) 2014; 20 Moon (10.1016/j.atherosclerosis.2018.01.031_bib7) 2003; 301 Escobales (10.1016/j.atherosclerosis.2018.01.031_bib13) 2005; 3 Martinez-Lemus (10.1016/j.atherosclerosis.2018.01.031_bib22) 2009; 24 Hertog (10.1016/j.atherosclerosis.2018.01.031_bib40) 1993; 342 Rodrigues (10.1016/j.atherosclerosis.2018.01.031_bib11) 2008; 18 Moraes (10.1016/j.atherosclerosis.2018.01.031_bib10) 2015; 243 Newby (10.1016/j.atherosclerosis.2018.01.031_bib41) 2006; 69 Touyz (10.1016/j.atherosclerosis.2018.01.031_bib1) 2011; 34 Viappiani (10.1016/j.atherosclerosis.2018.01.031_bib16) 2009; 77 Castro (10.1016/j.atherosclerosis.2018.01.031_bib45) 2012; 32 Griendling (10.1016/j.atherosclerosis.2018.01.031_bib2) 2003; 108 Martinez-Lemus (10.1016/j.atherosclerosis.2018.01.031_bib21) 2011; 300 Lee (10.1016/j.atherosclerosis.2018.01.031_bib37) 2004; 67 Duarte (10.1016/j.atherosclerosis.2018.01.031_bib36) 2001; 133 Rizzi (10.1016/j.atherosclerosis.2018.01.031_bib23) 2013; 165 Castro (10.1016/j.atherosclerosis.2018.01.031_bib12) 2009; 46 Barhoumi (10.1016/j.atherosclerosis.2018.01.031_bib34) 2017; 113 Sanchez (10.1016/j.atherosclerosis.2018.01.031_bib26) 2006; 24 Yan (10.1016/j.atherosclerosis.2018.01.031_bib6) 2013; 8 Navarro (10.1016/j.atherosclerosis.2018.01.031_bib31) 2016; 461 Montenegro (10.1016/j.atherosclerosis.2018.01.031_bib28) 2010; 382 Ceron (10.1016/j.atherosclerosis.2018.01.031_bib39) 2013; 65 Yoshizumi (10.1016/j.atherosclerosis.2018.01.031_bib5) 2002; 293 Bouvet (10.1016/j.atherosclerosis.2018.01.031_bib20) 2005; 45 Rice-Evans (10.1016/j.atherosclerosis.2018.01.031_bib27) 1996; 20 Castro (10.1016/j.atherosclerosis.2018.01.031_bib44) 2011; 64 Grote (10.1016/j.atherosclerosis.2018.01.031_bib14) 2003; 92 Ali (10.1016/j.atherosclerosis.2018.01.031_bib9) 2006; 291 Castro (10.1016/j.atherosclerosis.2018.01.031_bib18) 2008; 198 Dao (10.1016/j.atherosclerosis.2018.01.031_bib32) 2001; 19 Yogi (10.1016/j.atherosclerosis.2018.01.031_bib33) 2012; 264 Kleemann (10.1016/j.atherosclerosis.2018.01.031_bib8) 2011; 218 Ceron (10.1016/j.atherosclerosis.2018.01.031_bib43) 2012; 31 Simplicio (10.1016/j.atherosclerosis.2018.01.031_bib38) 2017; 73 Edwards (10.1016/j.atherosclerosis.2018.01.031_bib35) 2007; 137 |
References_xml | – volume: 92 start-page: e80 year: 2003 end-page: 86 ident: bib14 article-title: Mechanical stretch enhances mRNA expression and proenzyme release of matrix metalloproteinase-2 (MMP-2) via NAD(P)H oxidase-derived reactive oxygen species publication-title: Circ. Res. contributor: fullname: Luchtefeld – volume: 16 start-page: 8168 year: 2015 end-page: 8185 ident: bib30 article-title: Quercetin improves postischemic recovery of heart function in doxorubicin-treated rats and prevents doxorubicin-induced matrix metalloproteinase-2 activation and apoptosis induction publication-title: Int. J. Mol. Sci. contributor: fullname: Fogarassyova – volume: 32 start-page: 662 year: 2012 end-page: 668 ident: bib45 article-title: Matrix metalloproteinase-2 proteolysis of calponin-1 contributes to vascular hypocontractility in endotoxemic rats publication-title: Arterioscler. Thromb. Vasc. Biol. contributor: fullname: Cho – volume: 108 start-page: 2034 year: 2003 end-page: 2040 ident: bib2 article-title: Oxidative stress and cardiovascular injury: Part II: animal and human studies publication-title: Circulation contributor: fullname: FitzGerald – volume: 9 start-page: 435 year: 2014 end-page: 442 ident: bib29 article-title: Quercetin reduces oxidative stress and inhibits activation of cJun N terminal kinase/activator protein1 signaling in an experimental mouse model of abdominal aortic aneurysm publication-title: Mol. Med. Rep. contributor: fullname: Li – volume: 3 start-page: 231 year: 2005 end-page: 246 ident: bib13 article-title: Oxidative-nitrosative stress in hypertension publication-title: Curr. Vasc. Pharmacol. contributor: fullname: Crespo – volume: 24 start-page: 75 year: 2006 end-page: 84 ident: bib26 article-title: Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats publication-title: J. Hypertens. contributor: fullname: Vera – volume: 8 year: 2013 ident: bib6 article-title: Quercetin inhibits left ventricular hypertrophy in spontaneously hypertensive rats and inhibits angiotensin II-induced H9C2 cells hypertrophy by enhancing PPAR-gamma expression and suppressing AP-1 activity publication-title: PLoS One contributor: fullname: Wang – volume: 301 start-page: 1069 year: 2003 end-page: 1078 ident: bib7 article-title: Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9 publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Jung – volume: 46 start-page: 1298 year: 2009 end-page: 1307 ident: bib12 article-title: Antioxidant treatment reduces matrix metalloproteinase-2-induced vascular changes in renovascular hypertension publication-title: Free Radic. Biol. Med. contributor: fullname: Rodrigues – volume: 64 start-page: 551 year: 2011 end-page: 560 ident: bib44 article-title: Matrix metalloproteinase inhibitor properties of tetracyclines: therapeutic potential in cardiovascular diseases publication-title: Pharmacol. Res. contributor: fullname: Youssef – volume: 20 start-page: 2794 year: 2014 end-page: 2814 ident: bib3 article-title: NADPH oxidases in vascular pathology publication-title: Antioxidants Redox Signal. contributor: fullname: Czesnikiewicz-Guzik – volume: 137 start-page: 2405 year: 2007 end-page: 2411 ident: bib35 article-title: Quercetin reduces blood pressure in hypertensive subjects publication-title: J. Nutr. contributor: fullname: Litwin – start-page: 5 year: 2016 ident: bib25 article-title: Effects of quercetin on blood pressure: a systematic review and meta-analysis of randomized controlled trials publication-title: J Am Heart Assoc contributor: fullname: Zanchetti – volume: 291 start-page: L38 year: 2006 end-page: L45 ident: bib9 article-title: Stretch-induced phosphorylation of focal adhesion kinase in endothelial cells: role of mitochondrial oxidants publication-title: Am. J. Physiol. Lung Cell Mol. Physiol. contributor: fullname: Schumacker – volume: 293 start-page: 1458 year: 2002 end-page: 1465 ident: bib5 article-title: Quercetin glucuronide prevents VSMC hypertrophy by angiotensin II via the inhibition of JNK and AP-1 signaling pathway publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Suzaki – volume: 218 start-page: 44 year: 2011 end-page: 52 ident: bib8 article-title: Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models publication-title: Atherosclerosis contributor: fullname: Morrison – volume: 264 start-page: 470 year: 2012 end-page: 478 ident: bib33 article-title: Acute ethanol intake induces superoxide anion generation and mitogen-activated protein kinase phosphorylation in rat aorta: a role for angiotensin type 1 receptor publication-title: Toxicol. Appl. Pharmacol. contributor: fullname: Mecawi – volume: 67 start-page: 2103 year: 2004 end-page: 2114 ident: bib37 article-title: Transinactivation of the epidermal growth factor receptor tyrosine kinase and focal adhesion kinase phosphorylation by dietary flavonoids: effect on invasive potential of human carcinoma cells publication-title: Biochem. Pharmacol. contributor: fullname: Hwang – volume: 19 start-page: 1965 year: 2001 end-page: 1973 ident: bib32 article-title: Norepinephrine-induced aortic hyperplasia and extracellular matrix deposition are endothelin-dependent publication-title: J. Hypertens. contributor: fullname: de Champlain – volume: 461 start-page: 110 year: 2016 end-page: 113 ident: bib31 article-title: Reduced levels of potential circulating biomarkers of cardiovascular diseases in apparently healthy vegetarian men publication-title: Clin. Chim. Acta contributor: fullname: Rocha-Penha – volume: 300 start-page: H2005 year: 2011 end-page: H2015 ident: bib21 article-title: Inward remodeling of resistance arteries requires reactive oxygen species-dependent activation of matrix metalloproteinases publication-title: Am. J. Physiol. Heart Circ. Physiol. contributor: fullname: Galinanes – volume: 73 start-page: 5 year: 2017 end-page: 16 ident: bib38 article-title: Reactive oxygen species derived from NAD(P)H oxidase play a role on ethanol-induced hypertension and endothelial dysfunction in rat resistance arteries publication-title: J. Physiol. Biochem. contributor: fullname: Gonzaga – volume: 165 start-page: 165 year: 2013 end-page: 173 ident: bib23 article-title: Tempol inhibits TGF-beta and MMPs upregulation and prevents cardiac hypertensive changes publication-title: Int. J. Cardiol. contributor: fullname: Ceron – volume: 24 start-page: 45 year: 2009 end-page: 57 ident: bib22 article-title: The plastic nature of the vascular wall: a continuum of remodeling events contributing to control of arteriolar diameter and structure publication-title: Physiology contributor: fullname: Meininger – volume: 65 start-page: 47 year: 2013 end-page: 56 ident: bib39 article-title: Nebivolol attenuates prooxidant and profibrotic mechanisms involving TGF-beta and MMPs, and decreases vascular remodeling in renovascular hypertension publication-title: Free Radic. Biol. Med. contributor: fullname: Guimaraes – volume: 342 start-page: 1007 year: 1993 end-page: 1011 ident: bib40 article-title: Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study publication-title: Lancet contributor: fullname: Hollman – volume: 69 start-page: 614 year: 2006 end-page: 624 ident: bib41 article-title: Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates publication-title: Cardiovasc. Res. contributor: fullname: Newby – volume: 133 start-page: 117 year: 2001 end-page: 124 ident: bib36 article-title: Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats publication-title: Br. J. Pharmacol. contributor: fullname: Vargas – volume: 45 start-page: 432 year: 2005 end-page: 437 ident: bib20 article-title: Different involvement of extracellular matrix components in small and large arteries during chronic NO synthase inhibition publication-title: Hypertension contributor: fullname: Girardot – volume: 48 start-page: 433 year: 2010 end-page: 439 ident: bib24 article-title: Extracellular matrix alterations in hypertensive vascular remodeling publication-title: J. Mol. Cell. Cardiol. contributor: fullname: Lehoux – volume: 382 start-page: 293 year: 2010 end-page: 301 ident: bib28 article-title: Quercetin restores plasma nitrite and nitroso species levels in renovascular hypertension publication-title: Naunyn-Schmiedeberg’s Arch. Pharmacol. contributor: fullname: Dias-Junior – volume: 29 start-page: 194 year: 2010 end-page: 201 ident: bib19 article-title: Imbalance between matrix metalloproteinases and tissue inhibitor of metalloproteinases in hypertensive vascular remodeling publication-title: Matrix Biol. contributor: fullname: Prado – volume: 25 start-page: 977 year: 2004 end-page: 985 ident: bib4 article-title: Atheroprotective effects of antioxidants through inhibition of mitogen-activated protein kinases publication-title: Acta Pharmacol. Sin. contributor: fullname: Tsuchiya – volume: 113 start-page: 1753 year: 2017 end-page: 1762 ident: bib34 article-title: Matrix metalloproteinase-2 knockout prevents angiotensin II-induced vascular injury publication-title: Cardiovasc. Res. contributor: fullname: Mian – volume: 74 start-page: 196 year: 2007 end-page: 206 ident: bib42 article-title: TGF-beta signaling in vascular fibrosis publication-title: Cardiovasc. Res. contributor: fullname: Sanchez-Lopez – volume: 20 start-page: 933 year: 1996 end-page: 956 ident: bib27 article-title: Structure-antioxidant activity relationships of flavonoids and phenolic acids publication-title: Free Radic. Biol. Med. contributor: fullname: Paganga – volume: 98 start-page: 2572 year: 1996 end-page: 2579 ident: bib15 article-title: Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability publication-title: J. Clin. Invest. contributor: fullname: Ramasamy – volume: 52 start-page: 221 year: 2015 end-page: 231 ident: bib17 article-title: Matrix metalloproteinase 2 as a potential mediator of vascular smooth muscle cell migration and chronic vascular remodeling in hypertension publication-title: J. Vasc. Res. contributor: fullname: Castro – volume: 18 start-page: 176 year: 2008 end-page: 183 ident: bib11 article-title: Vitamin C improves the effect of a new nitric oxide donor on the vascular smooth muscle from renal hypertensive rats publication-title: Nitric Oxide contributor: fullname: Lima – volume: 31 start-page: 261 year: 2012 end-page: 270 ident: bib43 article-title: Time course involvement of matrix metalloproteinases in the vascular alterations of renovascular hypertension publication-title: Matrix Biol. contributor: fullname: Guimaraes – volume: 198 start-page: 320 year: 2008 end-page: 331 ident: bib18 article-title: Metalloproteinase inhibition ameliorates hypertension and prevents vascular dysfunction and remodeling in renovascular hypertensive rats publication-title: Atherosclerosis contributor: fullname: Figueiredo-Lopes – volume: 34 start-page: 5 year: 2011 end-page: 14 ident: bib1 article-title: Reactive oxygen species and vascular biology: implications in human hypertension publication-title: Hypertens. Res. contributor: fullname: Briones – volume: 243 start-page: 477 year: 2015 end-page: 485 ident: bib10 article-title: Alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells publication-title: Atherosclerosis contributor: fullname: Dias – volume: 77 start-page: 826 year: 2009 end-page: 834 ident: bib16 article-title: Activation and modulation of 72kDa matrix metalloproteinase-2 by peroxynitrite and glutathione publication-title: Biochem. Pharmacol. contributor: fullname: Holt – volume: 48 start-page: 433 year: 2010 ident: 10.1016/j.atherosclerosis.2018.01.031_bib24 article-title: Extracellular matrix alterations in hypertensive vascular remodeling publication-title: J. Mol. Cell. Cardiol. doi: 10.1016/j.yjmcc.2009.09.018 contributor: fullname: Lemarie – volume: 137 start-page: 2405 year: 2007 ident: 10.1016/j.atherosclerosis.2018.01.031_bib35 article-title: Quercetin reduces blood pressure in hypertensive subjects publication-title: J. Nutr. doi: 10.1093/jn/137.11.2405 contributor: fullname: Edwards – volume: 45 start-page: 432 year: 2005 ident: 10.1016/j.atherosclerosis.2018.01.031_bib20 article-title: Different involvement of extracellular matrix components in small and large arteries during chronic NO synthase inhibition publication-title: Hypertension doi: 10.1161/01.HYP.0000154680.44184.01 contributor: fullname: Bouvet – start-page: 5 year: 2016 ident: 10.1016/j.atherosclerosis.2018.01.031_bib25 article-title: Effects of quercetin on blood pressure: a systematic review and meta-analysis of randomized controlled trials publication-title: J Am Heart Assoc contributor: fullname: Serban – volume: 243 start-page: 477 year: 2015 ident: 10.1016/j.atherosclerosis.2018.01.031_bib10 article-title: Alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2015.09.026 contributor: fullname: Moraes – volume: 113 start-page: 1753 year: 2017 ident: 10.1016/j.atherosclerosis.2018.01.031_bib34 article-title: Matrix metalloproteinase-2 knockout prevents angiotensin II-induced vascular injury publication-title: Cardiovasc. Res. doi: 10.1093/cvr/cvx115 contributor: fullname: Barhoumi – volume: 342 start-page: 1007 year: 1993 ident: 10.1016/j.atherosclerosis.2018.01.031_bib40 article-title: Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study publication-title: Lancet doi: 10.1016/0140-6736(93)92876-U contributor: fullname: Hertog – volume: 31 start-page: 261 year: 2012 ident: 10.1016/j.atherosclerosis.2018.01.031_bib43 article-title: Time course involvement of matrix metalloproteinases in the vascular alterations of renovascular hypertension publication-title: Matrix Biol. doi: 10.1016/j.matbio.2012.01.009 contributor: fullname: Ceron – volume: 52 start-page: 221 year: 2015 ident: 10.1016/j.atherosclerosis.2018.01.031_bib17 article-title: Matrix metalloproteinase 2 as a potential mediator of vascular smooth muscle cell migration and chronic vascular remodeling in hypertension publication-title: J. Vasc. Res. doi: 10.1159/000441621 contributor: fullname: Belo – volume: 24 start-page: 45 year: 2009 ident: 10.1016/j.atherosclerosis.2018.01.031_bib22 article-title: The plastic nature of the vascular wall: a continuum of remodeling events contributing to control of arteriolar diameter and structure publication-title: Physiology doi: 10.1152/physiol.00029.2008 contributor: fullname: Martinez-Lemus – volume: 34 start-page: 5 year: 2011 ident: 10.1016/j.atherosclerosis.2018.01.031_bib1 article-title: Reactive oxygen species and vascular biology: implications in human hypertension publication-title: Hypertens. Res. doi: 10.1038/hr.2010.201 contributor: fullname: Touyz – volume: 20 start-page: 2794 year: 2014 ident: 10.1016/j.atherosclerosis.2018.01.031_bib3 article-title: NADPH oxidases in vascular pathology publication-title: Antioxidants Redox Signal. doi: 10.1089/ars.2013.5607 contributor: fullname: Konior – volume: 293 start-page: 1458 year: 2002 ident: 10.1016/j.atherosclerosis.2018.01.031_bib5 article-title: Quercetin glucuronide prevents VSMC hypertrophy by angiotensin II via the inhibition of JNK and AP-1 signaling pathway publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/S0006-291X(02)00407-2 contributor: fullname: Yoshizumi – volume: 3 start-page: 231 year: 2005 ident: 10.1016/j.atherosclerosis.2018.01.031_bib13 article-title: Oxidative-nitrosative stress in hypertension publication-title: Curr. Vasc. Pharmacol. doi: 10.2174/1570161054368643 contributor: fullname: Escobales – volume: 73 start-page: 5 year: 2017 ident: 10.1016/j.atherosclerosis.2018.01.031_bib38 article-title: Reactive oxygen species derived from NAD(P)H oxidase play a role on ethanol-induced hypertension and endothelial dysfunction in rat resistance arteries publication-title: J. Physiol. Biochem. doi: 10.1007/s13105-016-0519-z contributor: fullname: Simplicio – volume: 65 start-page: 47 year: 2013 ident: 10.1016/j.atherosclerosis.2018.01.031_bib39 article-title: Nebivolol attenuates prooxidant and profibrotic mechanisms involving TGF-beta and MMPs, and decreases vascular remodeling in renovascular hypertension publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2013.06.033 contributor: fullname: Ceron – volume: 64 start-page: 551 year: 2011 ident: 10.1016/j.atherosclerosis.2018.01.031_bib44 article-title: Matrix metalloproteinase inhibitor properties of tetracyclines: therapeutic potential in cardiovascular diseases publication-title: Pharmacol. Res. doi: 10.1016/j.phrs.2011.05.005 contributor: fullname: Castro – volume: 67 start-page: 2103 year: 2004 ident: 10.1016/j.atherosclerosis.2018.01.031_bib37 article-title: Transinactivation of the epidermal growth factor receptor tyrosine kinase and focal adhesion kinase phosphorylation by dietary flavonoids: effect on invasive potential of human carcinoma cells publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2004.02.023 contributor: fullname: Lee – volume: 19 start-page: 1965 year: 2001 ident: 10.1016/j.atherosclerosis.2018.01.031_bib32 article-title: Norepinephrine-induced aortic hyperplasia and extracellular matrix deposition are endothelin-dependent publication-title: J. Hypertens. doi: 10.1097/00004872-200111000-00006 contributor: fullname: Dao – volume: 108 start-page: 2034 year: 2003 ident: 10.1016/j.atherosclerosis.2018.01.031_bib2 article-title: Oxidative stress and cardiovascular injury: Part II: animal and human studies publication-title: Circulation doi: 10.1161/01.CIR.0000093661.90582.c4 contributor: fullname: Griendling – volume: 382 start-page: 293 year: 2010 ident: 10.1016/j.atherosclerosis.2018.01.031_bib28 article-title: Quercetin restores plasma nitrite and nitroso species levels in renovascular hypertension publication-title: Naunyn-Schmiedeberg’s Arch. Pharmacol. doi: 10.1007/s00210-010-0546-1 contributor: fullname: Montenegro – volume: 74 start-page: 196 year: 2007 ident: 10.1016/j.atherosclerosis.2018.01.031_bib42 article-title: TGF-beta signaling in vascular fibrosis publication-title: Cardiovasc. Res. doi: 10.1016/j.cardiores.2007.02.008 contributor: fullname: Ruiz-Ortega – volume: 218 start-page: 44 year: 2011 ident: 10.1016/j.atherosclerosis.2018.01.031_bib8 article-title: Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2011.04.023 contributor: fullname: Kleemann – volume: 92 start-page: e80 year: 2003 ident: 10.1016/j.atherosclerosis.2018.01.031_bib14 article-title: Mechanical stretch enhances mRNA expression and proenzyme release of matrix metalloproteinase-2 (MMP-2) via NAD(P)H oxidase-derived reactive oxygen species publication-title: Circ. Res. doi: 10.1161/01.RES.0000077044.60138.7C contributor: fullname: Grote – volume: 291 start-page: L38 year: 2006 ident: 10.1016/j.atherosclerosis.2018.01.031_bib9 article-title: Stretch-induced phosphorylation of focal adhesion kinase in endothelial cells: role of mitochondrial oxidants publication-title: Am. J. Physiol. Lung Cell Mol. Physiol. doi: 10.1152/ajplung.00287.2004 contributor: fullname: Ali – volume: 264 start-page: 470 year: 2012 ident: 10.1016/j.atherosclerosis.2018.01.031_bib33 article-title: Acute ethanol intake induces superoxide anion generation and mitogen-activated protein kinase phosphorylation in rat aorta: a role for angiotensin type 1 receptor publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2012.08.029 contributor: fullname: Yogi – volume: 46 start-page: 1298 year: 2009 ident: 10.1016/j.atherosclerosis.2018.01.031_bib12 article-title: Antioxidant treatment reduces matrix metalloproteinase-2-induced vascular changes in renovascular hypertension publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2009.02.011 contributor: fullname: Castro – volume: 8 year: 2013 ident: 10.1016/j.atherosclerosis.2018.01.031_bib6 article-title: Quercetin inhibits left ventricular hypertrophy in spontaneously hypertensive rats and inhibits angiotensin II-induced H9C2 cells hypertrophy by enhancing PPAR-gamma expression and suppressing AP-1 activity publication-title: PLoS One contributor: fullname: Yan – volume: 24 start-page: 75 year: 2006 ident: 10.1016/j.atherosclerosis.2018.01.031_bib26 article-title: Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats publication-title: J. Hypertens. doi: 10.1097/01.hjh.0000198029.22472.d9 contributor: fullname: Sanchez – volume: 29 start-page: 194 year: 2010 ident: 10.1016/j.atherosclerosis.2018.01.031_bib19 article-title: Imbalance between matrix metalloproteinases and tissue inhibitor of metalloproteinases in hypertensive vascular remodeling publication-title: Matrix Biol. doi: 10.1016/j.matbio.2009.11.005 contributor: fullname: Castro – volume: 133 start-page: 117 year: 2001 ident: 10.1016/j.atherosclerosis.2018.01.031_bib36 article-title: Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats publication-title: Br. J. Pharmacol. doi: 10.1038/sj.bjp.0704064 contributor: fullname: Duarte – volume: 18 start-page: 176 year: 2008 ident: 10.1016/j.atherosclerosis.2018.01.031_bib11 article-title: Vitamin C improves the effect of a new nitric oxide donor on the vascular smooth muscle from renal hypertensive rats publication-title: Nitric Oxide doi: 10.1016/j.niox.2007.12.002 contributor: fullname: Rodrigues – volume: 98 start-page: 2572 year: 1996 ident: 10.1016/j.atherosclerosis.2018.01.031_bib15 article-title: Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability publication-title: J. Clin. Invest. doi: 10.1172/JCI119076 contributor: fullname: Rajagopalan – volume: 198 start-page: 320 year: 2008 ident: 10.1016/j.atherosclerosis.2018.01.031_bib18 article-title: Metalloproteinase inhibition ameliorates hypertension and prevents vascular dysfunction and remodeling in renovascular hypertensive rats publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2007.10.011 contributor: fullname: Castro – volume: 32 start-page: 662 year: 2012 ident: 10.1016/j.atherosclerosis.2018.01.031_bib45 article-title: Matrix metalloproteinase-2 proteolysis of calponin-1 contributes to vascular hypocontractility in endotoxemic rats publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.111.242685 contributor: fullname: Castro – volume: 461 start-page: 110 year: 2016 ident: 10.1016/j.atherosclerosis.2018.01.031_bib31 article-title: Reduced levels of potential circulating biomarkers of cardiovascular diseases in apparently healthy vegetarian men publication-title: Clin. Chim. Acta doi: 10.1016/j.cca.2016.08.002 contributor: fullname: Navarro – volume: 9 start-page: 435 year: 2014 ident: 10.1016/j.atherosclerosis.2018.01.031_bib29 article-title: Quercetin reduces oxidative stress and inhibits activation of cJun N terminal kinase/activator protein1 signaling in an experimental mouse model of abdominal aortic aneurysm publication-title: Mol. Med. Rep. doi: 10.3892/mmr.2013.1846 contributor: fullname: Wang – volume: 69 start-page: 614 year: 2006 ident: 10.1016/j.atherosclerosis.2018.01.031_bib41 article-title: Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates publication-title: Cardiovasc. Res. doi: 10.1016/j.cardiores.2005.08.002 contributor: fullname: Newby – volume: 300 start-page: H2005 year: 2011 ident: 10.1016/j.atherosclerosis.2018.01.031_bib21 article-title: Inward remodeling of resistance arteries requires reactive oxygen species-dependent activation of matrix metalloproteinases publication-title: Am. J. Physiol. Heart Circ. Physiol. doi: 10.1152/ajpheart.01066.2010 contributor: fullname: Martinez-Lemus – volume: 301 start-page: 1069 year: 2003 ident: 10.1016/j.atherosclerosis.2018.01.031_bib7 article-title: Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/S0006-291X(03)00091-3 contributor: fullname: Moon – volume: 16 start-page: 8168 year: 2015 ident: 10.1016/j.atherosclerosis.2018.01.031_bib30 article-title: Quercetin improves postischemic recovery of heart function in doxorubicin-treated rats and prevents doxorubicin-induced matrix metalloproteinase-2 activation and apoptosis induction publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms16048168 contributor: fullname: Bartekova – volume: 25 start-page: 977 year: 2004 ident: 10.1016/j.atherosclerosis.2018.01.031_bib4 article-title: Atheroprotective effects of antioxidants through inhibition of mitogen-activated protein kinases publication-title: Acta Pharmacol. Sin. contributor: fullname: Kyaw – volume: 20 start-page: 933 year: 1996 ident: 10.1016/j.atherosclerosis.2018.01.031_bib27 article-title: Structure-antioxidant activity relationships of flavonoids and phenolic acids publication-title: Free Radic. Biol. Med. doi: 10.1016/0891-5849(95)02227-9 contributor: fullname: Rice-Evans – volume: 165 start-page: 165 year: 2013 ident: 10.1016/j.atherosclerosis.2018.01.031_bib23 article-title: Tempol inhibits TGF-beta and MMPs upregulation and prevents cardiac hypertensive changes publication-title: Int. J. Cardiol. doi: 10.1016/j.ijcard.2011.08.060 contributor: fullname: Rizzi – volume: 77 start-page: 826 year: 2009 ident: 10.1016/j.atherosclerosis.2018.01.031_bib16 article-title: Activation and modulation of 72kDa matrix metalloproteinase-2 by peroxynitrite and glutathione publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2008.11.004 contributor: fullname: Viappiani |
SSID | ssj0004718 |
Score | 2.5040543 |
Snippet | Increased activity of matrix metalloproteinase (MMP)-2 is observed in aortas of different models of hypertension, and its activation is directly mediated by... BACKGROUND AND AIMSIncreased activity of matrix metalloproteinase (MMP)-2 is observed in aortas of different models of hypertension, and its activation is... |
SourceID | proquest crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 146 |
SubjectTerms | Animals Antioxidant Antioxidants - pharmacology Aorta - drug effects Aorta - enzymology Aorta - pathology Aorta - physiopathology Disease Models, Animal Focal Adhesion Kinase 1 - metabolism Hypertension Hypertension, Renovascular - drug therapy Hypertension, Renovascular - enzymology Hypertension, Renovascular - pathology Hypertension, Renovascular - physiopathology Male Matrix metalloproteinase Matrix Metalloproteinase 2 - metabolism Oxidative stress Oxidative Stress - drug effects Phosphorylation Quercetin - pharmacology Rats, Wistar Reactive Oxygen Species - metabolism Signal Transduction - drug effects Vascular remodeling Vascular Remodeling - drug effects |
Title | Quercetin decreases the activity of matrix metalloproteinase-2 and ameliorates vascular remodeling in renovascular hypertension |
URI | https://dx.doi.org/10.1016/j.atherosclerosis.2018.01.031 https://www.ncbi.nlm.nih.gov/pubmed/29425960 https://search.proquest.com/docview/2001062955 |
Volume | 270 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3dS-QwEB_8APFF1Dt1zw8inI8926bptm-KKKuiICj4FpI0wYqbym4X7unuX3emH4qCIPhSaEnDkPlmfjMB-J0VRWxyrgOlwmGQJC4PsjxLApOq2KaJ4kpR7_DVdTq6Sy7uxf0cnPS9MASr7Gx_a9Mba919OexO8_C5LKnHF7UtooF0nERTzMMiuiOq1S4en1-Ort_aI4dRa5AJjYA_LMHBG8yribOqKe6Kz5IGeEdZM8iTR5-5qs9C0cYlna3CShdLsuOW3DWYs34dlq66avkP-H8zI9hKXXpWNNHh1E4ZEsKomYHujGCVY2Oa0f-XjW1NJfhmbEPpcWUQM-ULpsb2ibr4MSJlPWqVTWxzgQ56PYZ7T6x_BbSyB8xrJw0qvvI_4e7s9PZkFHQXLgQGVbNGb4X5CuYjVmCyqjmNfsNzzRzqcFZYZ0JViFRrEXFt3BATKY0ctkUeiiwzzhi-AQu-8nYLmOMYumjtIpWaxHKhUFKM02GuhhZjRj2AtD9b-dzO1ZA94OxRfmCKJKbIMJLIlAEc9ZyQ7wRFog_46hb7PQclKhNVSJS31YwWUYoc50IMYLNl7St1cY7mDfO9X98nYBuW6a2Fsu3AQj2Z2V2MbWq9B_N__kV7nQS_AF5X_6s |
link.rule.ids | 314,780,784,4502,24116,27924,27925,45585,45679 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3da9swED-6DrK-jH10W_apQfvo1bYsx37bKCvZlgQKLfRNSLJEPRa5JA70qf3XdyfbDRsUBnvJgyPEofv6HfrdCeCgqKrUlFxHSsWTKMtcGRVlkUUmV6nNM8WVot7h-SKfnmffL8TFDhwPvTBEq-xjfxfTQ7Tuvxz1p3l0VdfU44veltBAOk6mKR7Aw0wg-kWj_nSz5XlQ9O14HklEy0dwuCV5BZTVrHFP_K1pfHdShDGePLkvUd0HRENCOnkCj3skyb50wj6FHeufwWje35U_h9vTDZFW2tqzKmDDtV0zFIRRKwO9GMEax5Y0of-aLW1LF_BhaEPtcWWUMuUrppb2F_XwIx5lA2eVrWx4PgdzHsO9V9bf0VnZJVa1q8CJb_w-nJ98PTueRv1zC5FBx2wxV2G1gtWIFViqak6D3_BUC4ceXFTWmVhVItdaJFwbN8EySqN-bVXGoiiMM4a_gF3fePsKmOMIXLR2icpNZrlQaCfG6bhUE4uIUY8hH85WXnVTNeRAN_sp_1KKJKXIOJGolDF8HjQh_zATiRngX7f4OGhQoivR_YjyttnQIiqQ01KIMbzsVHsnXVpicMNq7_X_C_ABHk3P5jM5-7b48Qb26J-O1PYWdtvVxr5DlNPq98GKfwO8LQCT |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Quercetin+decreases+the+activity+of+matrix+metalloproteinase-2+and+ameliorates+vascular+remodeling+in+renovascular+hypertension&rft.jtitle=Atherosclerosis&rft.au=Pereira%2C+Sherliane+C&rft.au=Parente%2C+Juliana+M&rft.au=Belo%2C+Vanessa+A&rft.au=Mendes%2C+Atlante+S&rft.date=2018-03-01&rft.eissn=1879-1484&rft.volume=270&rft.spage=146&rft_id=info:doi/10.1016%2Fj.atherosclerosis.2018.01.031&rft_id=info%3Apmid%2F29425960&rft.externalDocID=29425960 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9150&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9150&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9150&client=summon |