Screening Marine Natural Products for New Drug Leads against Trypanosomatids and Malaria

• Published in: Marine drugs Vol. 18; no. 4; p. 187
• Main Authors: Álvarez-Bardón, María, Pérez-Pertejo, Yolanda, Ordóñez, César, Sepúlveda-Crespo, Daniel, Carballeira, Nestor M., Tekwani, Babu L., Murugesan, Sankaranarayanan, Martinez-Valladares, Maria, García-Estrada, Carlos, Reguera, Rosa M., Balaña-Fouce, Rafael
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 31.03.2020; MDPI AG
• Subjects: Animals; Antiprotozoal Agents - pharmacology; Antiprotozoal Agents - therapeutic use; Aquatic Organisms - chemistry; Biological Products - pharmacology; Biological Products - therapeutic use; Drug Discovery; Drug Resistance; Euglenozoa Infections - drug therapy; Euglenozoa Infections - parasitology; high-throughput screening; High-Throughput Screening Assays; Humans; malaria; Malaria, Falciparum - drug therapy; Malaria, Falciparum - parasitology; Neglected Diseases - drug therapy; Neglected Diseases - parasitology; neglected tropical diseases; phenotypic screening; Plasmodium falciparum - drug effects; Plasmodium malariae - drug effects; Plasmodium malariae - pathogenicity; Review; target-based screening; trypanosomatids; Trypanosomatina - drug effects; trypanosomatids; marine pharmacology; neglected tropical diseases; high-throughput screening; target-based screening; chloroquine derivatives; phenotypic screening; malaria

Neglected Tropical Diseases (NTD) represent a serious threat to humans, especially for those living in poor or developing countries. Almost one-sixth of the world population is at risk of suffering from these diseases and many thousands die because of NTDs, to which we should add the sanitary, labor...