Mutant metabolic enzymes are at the origin of gliomas
Mutations of the isocitrate dehydrogenase (IDH) metabolic enzymes IDH1 and IDH2 have been found to be frequent and early genetic alterations in astrocytomas and oligodendrogliomas. All mutations identified to date affect a single amino acid located within the isocitrate binding site (R132 of IDH1 an...
Saved in:
| Published in | Cancer research (Chicago, Ill.) Vol. 69; no. 24; pp. 9157 - 9159 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
15.12.2009
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Mutations of the isocitrate dehydrogenase (IDH) metabolic enzymes IDH1 and IDH2 have been found to be frequent and early genetic alterations in astrocytomas and oligodendrogliomas. All mutations identified to date affect a single amino acid located within the isocitrate binding site (R132 of IDH1 and the analogous R172 residue of IDH2). IDH1 and IDH2 mutations define a specific subtype of gliomas and may have significant utility for the diagnosis, prognosis, and treatment of patients with these tumors. |
|---|---|
| AbstractList | Mutations of the
isocitrate dehydrogenase
(
IDH
) metabolic enzymes
IDH1
and
IDH2
have been found to be frequent and early genetic alterations in astrocytomas and oligodendrogliomas. All mutations identified to date affect a single amino acid located within the isocitrate binding site (R132 of
IDH1
and the analogous R172 residue of
IDH2
).
IDH1
and
IDH2
mutations define a specific subtype of gliomas and may have significant utility for the diagnosis, prognosis, and treatment of patients with these tumors. Mutations of the isocitrate dehydrogenase (IDH) metabolic enzymes IDH1 and IDH2 have been found to be frequent and early genetic alterations in astrocytomas and oligodendrogliomas. All mutations identified to date affect a single amino acid located within the isocitrate binding site (R132 of IDH1 and the analogous R172 residue of IDH2). IDH1 and IDH2 mutations define a specific subtype of gliomas and may have significant utility for the diagnosis, prognosis, and treatment of patients with these tumors. Abstract Mutations of the isocitrate dehydrogenase (IDH) metabolic enzymes IDH1 and IDH2 have been found to be frequent and early genetic alterations in astrocytomas and oligodendrogliomas. All mutations identified to date affect a single amino acid located within the isocitrate binding site (R132 of IDH1 and the analogous R172 residue of IDH2). IDH1 and IDH2 mutations define a specific subtype of gliomas and may have significant utility for the diagnosis, prognosis, and treatment of patients with these tumors. [Cancer Res 2009;69(24):9157–9] |
| Author | Velculescu, Victor Yan, Hai Parsons, D Williams Bigner, Darell D |
| AuthorAffiliation | 1 The Pediatric Brain Tumor Foundation Institute, the Preston Robert Tisch Brain Tumor Center, and the Department of Pathology, Duke University Medical Center, Durham, NC 27710 2 The Ludwig Center for Cancer Genetics and Therapeutics at Johns Hopkins Kimmel Cancer Center, Baltimore, MD |
| AuthorAffiliation_xml | – name: 2 The Ludwig Center for Cancer Genetics and Therapeutics at Johns Hopkins Kimmel Cancer Center, Baltimore, MD – name: 1 The Pediatric Brain Tumor Foundation Institute, the Preston Robert Tisch Brain Tumor Center, and the Department of Pathology, Duke University Medical Center, Durham, NC 27710 |
| Author_xml | – sequence: 1 givenname: Hai surname: Yan fullname: Yan, Hai email: hai.yan@duke.edu organization: The Pediatric Brain Tumor Foundation Institute, Duke University Medical Center, Durham, North Carolina, USA. hai.yan@duke.edu – sequence: 2 givenname: Darell D surname: Bigner fullname: Bigner, Darell D – sequence: 3 givenname: Victor surname: Velculescu fullname: Velculescu, Victor – sequence: 4 givenname: D Williams surname: Parsons fullname: Parsons, D Williams |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19996293$$D View this record in MEDLINE/PubMed |
| BookMark | eNpVkE9LAzEQxYNUbKt-BGVvnrYmu8lmcxFK8R9Uveg5pOmkjewmNdkV6qd315aqMDAM8-a94TdGA-cdIHRB8IQQVl5jjMuUUZ5NZtPnFIs0Kxg-QiPC8jLllLIBGh00QzSO8b0bGcHsBA2JEKLIRD5C7KltlGuSGhq18JXVCbivbQ0xUQES1STNGhIf7Mq6xJtkVVlfq3iGjo2qIpzv-yl6u7t9nT2k85f7x9l0nuouqEn5glKyAK4MWxpqDNVKM8pA6C4_56YrVixxQQ0UQAXwXHCW6bKkJc7KkuSn6Gbnu2kXNSw1uCaoSm6CrVXYSq-s_L9xdi1X_lNmXFDxY3C1Nwj-o4XYyNpGDVWlHPg2Sp5TIggVvZLtlDr4GAOYQwrBsicue5qypyk74hIL2RPv7i7_vvh7tUecfwO7OX58 |
| CitedBy_id | crossref_primary_10_1016_j_bj_2015_10_002 crossref_primary_10_1002_glia_21130 crossref_primary_10_1016_j_bmc_2017_01_012 crossref_primary_10_1200_JCO_2010_33_8715 crossref_primary_10_1007_s11060_014_1495_1 crossref_primary_10_1016_j_addr_2014_01_010 crossref_primary_10_1186_1471_2164_16_S1_S1 crossref_primary_10_3892_etm_2012_676 crossref_primary_10_1080_15384047_2016_1210743 crossref_primary_10_3109_15513815_2012_659383 crossref_primary_10_1093_neuonc_not243 crossref_primary_10_3390_cancers15041037 crossref_primary_10_1007_s11011_021_00690_y crossref_primary_10_1007_s00701_016_2928_8 crossref_primary_10_1007_s11060_010_0499_8 crossref_primary_10_3390_cancers13174299 crossref_primary_10_1007_s00401_010_0763_1 crossref_primary_10_1042_BST20160094 crossref_primary_10_1186_s12935_021_01818_x crossref_primary_10_1038_s41388_021_01968_2 crossref_primary_10_3390_cancers14102416 crossref_primary_10_1016_j_cancergencyto_2010_10_002 crossref_primary_10_1002_jmri_26964 crossref_primary_10_1158_1078_0432_CCR_13_3052 crossref_primary_10_1007_s11060_012_0925_1 crossref_primary_10_1007_s11060_011_0714_2 crossref_primary_10_18632_aging_101769 crossref_primary_10_1007_s11060_011_0787_y crossref_primary_10_1093_neuonc_not063 crossref_primary_10_2217_cns_12_19 crossref_primary_10_1007_s10147_011_0323_2 crossref_primary_10_1101_gr_132738_111 crossref_primary_10_3389_fonc_2019_00417 crossref_primary_10_1038_nrclinonc_2016_60 crossref_primary_10_1002_ana_22390 crossref_primary_10_1016_j_bbamcr_2010_08_011 crossref_primary_10_1016_j_bbabio_2016_12_003 crossref_primary_10_1038_cddis_2016_318 crossref_primary_10_1158_0008_5472_CAN_14_0924 crossref_primary_10_1097_NEN_0b013e31820e1152 crossref_primary_10_1097_PAS_0b013e31827ab703 crossref_primary_10_1002_mc_21863 crossref_primary_10_3390_molecules28072890 crossref_primary_10_18632_oncotarget_20836 crossref_primary_10_1038_onc_2010_471 crossref_primary_10_1038_leu_2010_307 crossref_primary_10_1097_CCO_0b013e32834d816a crossref_primary_10_3109_02688697_2013_771139 crossref_primary_10_3390_biomedicines8090294 crossref_primary_10_1002_cncr_25637 crossref_primary_10_1007_s10014_014_0211_3 crossref_primary_10_1016_j_ijrobp_2010_06_012 crossref_primary_10_1007_s00894_022_05409_z crossref_primary_10_1007_s00381_010_1264_1 crossref_primary_10_3390_cancers14215386 crossref_primary_10_1007_s11060_010_0369_4 crossref_primary_10_1007_s11910_013_0345_4 crossref_primary_10_1111_1759_7714_12127 crossref_primary_10_1016_j_anndiagpath_2011_11_003 crossref_primary_10_1016_j_bbcan_2024_189102 crossref_primary_10_1007_s11060_012_1026_x crossref_primary_10_1016_j_ccr_2009_12_031 crossref_primary_10_1097_PDM_0b013e31826c7ff8 crossref_primary_10_1007_s00701_010_0784_5 crossref_primary_10_1017_cjn_2020_10 crossref_primary_10_1007_s00726_010_0609_0 crossref_primary_10_3390_cancers12040787 crossref_primary_10_3390_ijms24087076 crossref_primary_10_1186_gm470 crossref_primary_10_1016_j_celrep_2018_03_133 crossref_primary_10_1007_s13167_011_0137_3 crossref_primary_10_1021_jacs_5b07627 crossref_primary_10_1016_j_neuroimage_2010_11_001 crossref_primary_10_1309_AJCPD7NR2RMNQDVF crossref_primary_10_3174_ajnr_A2950 crossref_primary_10_3389_fonc_2022_798018 crossref_primary_10_1016_j_molmed_2010_07_002 crossref_primary_10_1016_j_bbrc_2022_03_081 crossref_primary_10_3390_cells10092345 crossref_primary_10_1038_bjc_2011_162 crossref_primary_10_1038_onc_2010_307 crossref_primary_10_1111_eci_12361 crossref_primary_10_1155_2012_302875 crossref_primary_10_1093_neuonc_nor087 crossref_primary_10_1093_neuonc_nou113 crossref_primary_10_2176_nmc_oa2012_0409 crossref_primary_10_1093_neuonc_nou112 crossref_primary_10_1016_j_febslet_2010_06_009 crossref_primary_10_1016_j_mrfmmm_2021_111773 crossref_primary_10_1007_s11910_017_0722_5 crossref_primary_10_1002_wsbm_1334 crossref_primary_10_1007_s10014_011_0050_4 crossref_primary_10_1158_1078_0432_CCR_12_1773 crossref_primary_10_1007_s11910_012_0263_x crossref_primary_10_1007_s12253_012_9588_7 crossref_primary_10_1093_jnen_nly026 crossref_primary_10_1016_j_clinimag_2022_10_011 crossref_primary_10_1177_0192623310389477 crossref_primary_10_1371_journal_pone_0016812 crossref_primary_10_1074_mcp_M110_000661 crossref_primary_10_1053_j_semdp_2016_08_008 |
| Cites_doi | 10.2353/ajpath.2007.070011 10.1200/JCO.2009.21.9832 10.1126/science.1164382 10.1002/ijc.24379 10.1007/s00401-009-0550-z 10.1056/NEJMoa0903840 10.1126/science.1170944 10.1215/15228517-2009-025 10.2353/ajpath.2009.080958 10.1007/s00401-008-0455-2 10.1056/NEJMoa0808710 10.1007/s00401-009-0561-9 10.4161/cc.8.11.8594 10.1126/science.1160809 10.1074/jbc.M404298200 10.1002/humu.20937 10.1126/science.1133427 10.1056/NEJMe0810213 10.1126/science.123.3191.309 10.1016/j.molcel.2008.04.009 10.1038/sj.onc.1209594 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 5PM |
| DOI | 10.1158/0008-5472.CAN-09-2650 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE CrossRef |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1538-7445 |
| EndPage | 9159 |
| ExternalDocumentID | 10_1158_0008_5472_CAN_09_2650 19996293 |
| Genre | Journal Article Review |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: R01 CA118822-03 – fundername: NCI NIH HHS grantid: R01 CA140316 – fundername: NCI NIH HHS grantid: R01 CA118822 |
| GroupedDBID | --- -ET .55 18M 29B 2WC 34G 39C 3O- 476 53G 5GY 5RE 5VS 6J9 8WZ A6W ABOCM ACGFO ACIWK ACPRK ACSVP ADBBV ADCOW AENEX AFFNX AFHIN AFOSN AFRAH AI. ALMA_UNASSIGNED_HOLDINGS BAWUL BTFSW C1A CGR CS3 CUY CVF DIK DU5 EBS ECM EIF EJD F5P FRP GX1 H13 IH2 KQ8 L7B LSO NPM OHT OK1 P0W P2P PQQKQ RCR RHF RHI RNS SJN TR2 UDS VH1 W2D W8F WH7 WOQ X7M XJT YKV YZZ ZCG AAYXX CITATION 7X8 5PM AETEA |
| ID | FETCH-LOGICAL-c510t-7b441be7af5df4ff4cac545e9c99937f37f56d064fe6e49e739752c8848028813 |
| ISSN | 0008-5472 |
| IngestDate | Tue Sep 17 21:23:17 EDT 2024 Fri Oct 25 03:07:09 EDT 2024 Thu Sep 26 17:49:31 EDT 2024 Sat Sep 28 07:50:15 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 24 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c510t-7b441be7af5df4ff4cac545e9c99937f37f56d064fe6e49e739752c8848028813 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Current Address: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston TX |
| OpenAccessLink | https://aacrjournals.org/cancerres/article-pdf/69/24/9157/2616844/9157.pdf |
| PMID | 19996293 |
| PQID | 734191491 |
| PQPubID | 23479 |
| PageCount | 3 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_2794981 proquest_miscellaneous_734191491 crossref_primary_10_1158_0008_5472_CAN_09_2650 pubmed_primary_19996293 |
| PublicationCentury | 2000 |
| PublicationDate | 2009-12-15 |
| PublicationDateYYYYMMDD | 2009-12-15 |
| PublicationDate_xml | – month: 12 year: 2009 text: 2009-12-15 day: 15 |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Cancer research (Chicago, Ill.) |
| PublicationTitleAlternate | Cancer Res |
| PublicationYear | 2009 |
| References | 19657110 - N Engl J Med. 2009 Sep 10;361(11):1058-66 19359588 - Science. 2009 Apr 10;324(5924):261-5 13298683 - Science. 1956 Feb 24;123(3191):309-14 19378339 - Int J Cancer. 2009 Jul 15;125(2):353-5 17456751 - Am J Pathol. 2007 May;170(5):1445-53 19117336 - Hum Mutat. 2009 Jan;30(1):7-11 15173171 - J Biol Chem. 2004 Aug 6;279(32):33946-57 19228619 - N Engl J Med. 2009 Feb 19;360(8):765-73 19460998 - Science. 2009 May 22;324(5930):1029-33 19246647 - Am J Pathol. 2009 Apr;174(4):1149-53 19228626 - N Engl J Med. 2009 Feb 19;360(8):813-5 19636000 - J Clin Oncol. 2009 Sep 1;27(25):4150-4 16959974 - Science. 2006 Oct 13;314(5797):268-74 18772396 - Science. 2008 Sep 26;321(5897):1807-12 19458374 - N Engl J Med. 2009 May 21;360(21):2248; author reply 2249 16892081 - Oncogene. 2006 Aug 7;25(34):4675-82 19435942 - Neuro Oncol. 2009 Aug;11(4):341-7 18498744 - Mol Cell. 2008 May 23;30(4):393-402 18985363 - Acta Neuropathol. 2008 Dec;116(6):597-602 19411854 - Cell Cycle. 2009 Jun 1;8(11):1806-7 19554337 - Acta Neuropathol. 2009 Oct;118(4):469-74 19543740 - Acta Neuropathol. 2009 Sep;118(3):401-5 Parsons (2022061701362447100_bib2) 2008; 321 Balss (2022061701362447100_bib3) 2008; 116 Warburg (2022061701362447100_bib21) 1956; 123 Bleeker (2022061701362447100_bib4) 2009; 30 Watanabe (2022061701362447100_bib8) 2009; 174 Kang (2022061701362447100_bib7) 2009; 125 Korshunov (2022061701362447100_bib12) 2009; 118 Sjoblom (2022061701362447100_bib14) 2006; 314 Yan (2022061701362447100_bib5) 2009; 360 Vander Heiden (2022061701362447100_bib22) 2009; 324 Xu (2022061701362447100_bib11) 2004; 279 Ohgaki (2022061701362447100_bib1) 2007; 170 King (2022061701362447100_bib19) 2006; 25 Hayden (2022061701362447100_bib10) 2009; 8 Ichimura (2022061701362447100_bib6) 2009; 11 Hartmann (2022061701362447100_bib9) 2009; 118 De Carli (2022061701362447100_bib15) 2009; 360 Kaelin (2022061701362447100_bib18) 2008; 30 Mardis (2022061701362447100_bib13) 2009; 361 Zhao (2022061701362447100_bib17) 2009; 324 Sanson (2022061701362447100_bib16) 2009; 27 Thompson (2022061701362447100_bib20) 2009; 360 |
| References_xml | – volume: 170 start-page: 1445 year: 2007 ident: 2022061701362447100_bib1 article-title: Genetic pathways to primary and secondary glioblastoma publication-title: Am J Pathol doi: 10.2353/ajpath.2007.070011 contributor: fullname: Ohgaki – volume: 27 start-page: 4150 year: 2009 ident: 2022061701362447100_bib16 article-title: Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas publication-title: J Clin Oncol doi: 10.1200/JCO.2009.21.9832 contributor: fullname: Sanson – volume: 321 start-page: 1807 year: 2008 ident: 2022061701362447100_bib2 article-title: An integrated genomic analysis of human glioblastoma multiforme publication-title: Science doi: 10.1126/science.1164382 contributor: fullname: Parsons – volume: 125 start-page: 353 year: 2009 ident: 2022061701362447100_bib7 article-title: Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers publication-title: Int J Cancer doi: 10.1002/ijc.24379 contributor: fullname: Kang – volume: 118 start-page: 401 year: 2009 ident: 2022061701362447100_bib12 article-title: Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma publication-title: Acta Neuropathol doi: 10.1007/s00401-009-0550-z contributor: fullname: Korshunov – volume: 361 start-page: 1058 year: 2009 ident: 2022061701362447100_bib13 article-title: Recurring mutations found by sequencing an acute myeloid leukemia genome publication-title: N Engl J Med doi: 10.1056/NEJMoa0903840 contributor: fullname: Mardis – volume: 324 start-page: 261 year: 2009 ident: 2022061701362447100_bib17 article-title: Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha publication-title: Science doi: 10.1126/science.1170944 contributor: fullname: Zhao – volume: 11 start-page: 341 year: 2009 ident: 2022061701362447100_bib6 article-title: IDH1 mutations are present in the majority of common adult gliomas but are rare in primary glioblastomas publication-title: Neuro-oncol doi: 10.1215/15228517-2009-025 contributor: fullname: Ichimura – volume: 174 start-page: 1149 year: 2009 ident: 2022061701362447100_bib8 article-title: IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas publication-title: Am J Pathol doi: 10.2353/ajpath.2009.080958 contributor: fullname: Watanabe – volume: 116 start-page: 597 year: 2008 ident: 2022061701362447100_bib3 article-title: Analysis of the IDH1 codon 132 mutation in brain tumors publication-title: Acta Neuropathol doi: 10.1007/s00401-008-0455-2 contributor: fullname: Balss – volume: 360 start-page: 765 year: 2009 ident: 2022061701362447100_bib5 article-title: IDH1 and IDH2 mutations in gliomas publication-title: N Engl J Med doi: 10.1056/NEJMoa0808710 contributor: fullname: Yan – volume: 118 start-page: 469 year: 2009 ident: 2022061701362447100_bib9 article-title: Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas publication-title: Acta Neuropathol doi: 10.1007/s00401-009-0561-9 contributor: fullname: Hartmann – volume: 8 start-page: 1806 year: 2009 ident: 2022061701362447100_bib10 article-title: Frequent IDH1 mutations in supratentorial primitive neuroectodermal tumors (sPNET) of adults but not children publication-title: Cell Cycle doi: 10.4161/cc.8.11.8594 contributor: fullname: Hayden – volume: 360 start-page: 2248, author reply 9 year: 2009 ident: 2022061701362447100_bib15 article-title: IDH1 and IDH2 mutations in gliomas publication-title: N Engl J Med contributor: fullname: De Carli – volume: 324 start-page: 1029 year: 2009 ident: 2022061701362447100_bib22 article-title: Understanding the Warburg effect: the metabolic requirements of cell proliferation publication-title: Science doi: 10.1126/science.1160809 contributor: fullname: Vander Heiden – volume: 279 start-page: 33946 year: 2004 ident: 2022061701362447100_bib11 article-title: Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity publication-title: J Biol Chem doi: 10.1074/jbc.M404298200 contributor: fullname: Xu – volume: 30 start-page: 7 year: 2009 ident: 2022061701362447100_bib4 article-title: IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors publication-title: Hum Mutat doi: 10.1002/humu.20937 contributor: fullname: Bleeker – volume: 314 start-page: 268 year: 2006 ident: 2022061701362447100_bib14 article-title: The consensus coding sequences of human breast and colorectal cancers publication-title: Science doi: 10.1126/science.1133427 contributor: fullname: Sjoblom – volume: 360 start-page: 813 year: 2009 ident: 2022061701362447100_bib20 article-title: Metabolic enzymes as oncogenes or tumor suppressors publication-title: N Engl J Med doi: 10.1056/NEJMe0810213 contributor: fullname: Thompson – volume: 123 start-page: 309 year: 1956 ident: 2022061701362447100_bib21 article-title: On the origin of cancer cells publication-title: Science doi: 10.1126/science.123.3191.309 contributor: fullname: Warburg – volume: 30 start-page: 393 year: 2008 ident: 2022061701362447100_bib18 article-title: Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway publication-title: Mol Cell doi: 10.1016/j.molcel.2008.04.009 contributor: fullname: Kaelin – volume: 25 start-page: 4675 year: 2006 ident: 2022061701362447100_bib19 article-title: Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer publication-title: Oncogene doi: 10.1038/sj.onc.1209594 contributor: fullname: King |
| SSID | ssj0005105 |
| Score | 2.4133015 |
| SecondaryResourceType | review_article |
| Snippet | Mutations of the isocitrate dehydrogenase (IDH) metabolic enzymes IDH1 and IDH2 have been found to be frequent and early genetic alterations in astrocytomas... Abstract Mutations of the isocitrate dehydrogenase (IDH) metabolic enzymes IDH1 and IDH2 have been found to be frequent and early genetic alterations in... Mutations of the isocitrate dehydrogenase ( IDH ) metabolic enzymes IDH1 and IDH2 have been found to be frequent and early genetic alterations in astrocytomas... |
| SourceID | pubmedcentral proquest crossref pubmed |
| SourceType | Open Access Repository Aggregation Database Index Database |
| StartPage | 9157 |
| SubjectTerms | Astrocytoma - enzymology Astrocytoma - genetics Central Nervous System Neoplasms - enzymology Central Nervous System Neoplasms - genetics Glioblastoma - enzymology Glioblastoma - genetics Humans Isocitrate Dehydrogenase - genetics Mutation |
| Title | Mutant metabolic enzymes are at the origin of gliomas |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/19996293 https://search.proquest.com/docview/734191491 https://pubmed.ncbi.nlm.nih.gov/PMC2794981 |
| Volume | 69 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBZtCqWX0nc3faBDb8Hu2itZ0jGkLUvLFgpJSU_GUqRmwfGG1D40vz4zkvzYJIW2sJjFNhKebzx8kme-IeRdXi0cL5RODDYCZErPE2UlT0xRCKGsUGaBxcmrr8XyiH0-5sdj7YmvLml1ai5vrSv5H1ThHOCKVbL_gOwwKJyA_4AvHAFhOP4VxqsOewBjF2iAEtWqbXP5G9WXMJ0rVCnuhc5XyAl_1ushGWjUJjD2Yi8q_pz6T7ohN8PHjrpOJzsFP8Je6bJaT3bWY73MB5ixrsf04e-2Nh1KRXU-kXZtgqhxX2gNJD_Q90EVYmv3wbdOCPWXqR0jpmBBE7IPqaH7SnSdnE0CpMqCHvXNyM1lSHWUCWciTw_2cQ8pyYugSztB8_zMw4n6CUUe2itek8zuL90l93KIP5jp9-XbKCKPnDIWc8Gs72-d04vJhlG2GcuNZcj1bNoJPTl8RB7GdQXdD07ymNyxzRNyfxUzJ54SHnyFDr5Co69QQI5WLQVfocFX6MbR6CvPyNGnj4cHyyS2zEgMPFWbCA30VltROX7imHPMVAY4slVGIRF18OPFCdBQZwvL4F0EOspzIyWTQDRltnhOdppNY18SyvU80xrCs-CGGemURvIvs6pi80orNyNpb5byPCijlH5FySVmNMgSTVqCScu5KtGkM0J745UQw_DDVNXYTferFCgqCEv1bEZeBFuOI0YQZkRsWXm4AeXRt68061Mvkw7QMyWz3T-O-Yo8GF36NdlpLzr7Bihmq996h7kC1EZ2Uw |
| link.rule.ids | 230,315,783,787,888,27938,27939 |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mutant+metabolic+enzymes+are+at+the+origin+of+gliomas&rft.jtitle=Cancer+research+%28Chicago%2C+Ill.%29&rft.au=Yan%2C+Hai&rft.au=Bigner%2C+Darell+D&rft.au=Velculescu%2C+Victor&rft.au=Parsons%2C+D+Williams&rft.date=2009-12-15&rft.eissn=1538-7445&rft.volume=69&rft.issue=24&rft.spage=9157&rft_id=info:doi/10.1158%2F0008-5472.CAN-09-2650&rft_id=info%3Apmid%2F19996293&rft.externalDocID=19996293 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0008-5472&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0008-5472&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0008-5472&client=summon |