An integrated metabonomic and proteomic study on Kidney-Yin Deficiency Syndrome patients with diabetes mellitus in China

• Published in: Acta pharmacologica Sinica Vol. 36; no. 6; pp. 689 - 698
• Main Authors: Jiang, Ning, Liu, Hong-fang, Li, Si-di, Zhou, Wen-xia, Zhang, Yong-xiang, Zhang, Qi, Yan, Xian-zhong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2015; Nature Publishing Group
• Subjects: Aged; Biomarkers - blood; Biomarkers - urine; Biomedical and Life Sciences; Biomedicine; Blood Proteins - analysis; Case-Control Studies; China; Diabetes Mellitus - blood; Diabetes Mellitus - diagnosis; Diabetes Mellitus - urine; Female; Humans; Immunology; Internal Medicine; Kidney - metabolism; Male; Medical Microbiology; Metabolomics - methods; Middle Aged; Multivariate Analysis; Original; original-article; Pharmacology/Toxicology; Predictive Value of Tests; Proteomics - methods; Proton Magnetic Resonance Spectroscopy; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Systems Biology; Systems Integration; Urinalysis; Vaccine; Yin Deficiency - blood; Yin Deficiency - diagnosis; Yin Deficiency - urine; 中国; 代谢组学; 患者; 糖尿病; 苯丙氨酸; 虚证; 蛋白质组学; 集成; China; metabonomics; traditional Chinese medicine; diabetes mellitus; proteomics; Kidney-Yin Deficiency syndrome

Aim： To investigate specific changes in metabolites and proteins of Kidney-Yin Deficiency Syndrome （KYDS） patients with diabetes mellitus （DM） in China. Methods： KYDS （n=29） and non-KYDS （n=23） patients with DM were recruited for this study. The KYDS was diagnosed by two senior TCM clinicians separa...