Abnormalities in connectivity of white-matter tracts in patients with familial and non-familial schizophrenia

• Published in: Psychological medicine Vol. 41; no. 8; pp. 1691 - 1700
• Main Authors: Wang, Q., Deng, W., Huang, C., Li, M., Ma, X., Wang, Y., Jiang, L., Lui, S., Huang, X., Chua, S. E., Cheung, C., McAlonan, G. M., Sham, P. C., Murray, R. M., Collier, D. A., Gong, Q., Li, T.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.08.2011
• Subjects: Adult; Adult and adolescent clinical studies; Analysis of Variance; Biological and medical sciences; Brain; Brain - pathology; Case-Control Studies; Chi-Square Distribution; Diffusion Tensor Imaging; Families & family life; Family; Family histories; Female; First time; Humans; Integrity; Magnetic Resonance Imaging; Male; Matter & antimatter; Medical sciences; Psychiatric disorders; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Schizophrenia; Schizophrenia - genetics; Schizophrenia - pathology; Young Adult; DTI; fractional anisotropy; first episode; schizophrenia; voxel-based analysis; family history; Psychosis; Human; Family story; First episode; Anisotropy; Schizophrenia; White matter

Abnormalities in the connectivity of white-matter (WM) tracts in schizophrenia are supported by evidence from post-mortem investigations, functional and structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). The aims of this study were to explore the microstructural changes...