Decreased Incidence of Hepatocellular Carcinoma in Hepatitis B Vaccinees: A 20-Year Follow-up Study

• Published in: JNCI : Journal of the National Cancer Institute Vol. 101; no. 19; pp. 1348 - 1355
• Main Authors: Chang, Mei-Hwei, You, San-Lin, Chen, Chien-Jen, Liu, Chun-Jen, Lee, Chuan-Mo, Lin, Shi-Ming, Chu, Heng-Cheng, Wu, Tzee-Chung, Yang, Sheng-Shun, Kuo, Hsu-Sung, Chen, Ding-Shinn
• Format: Journal Article
• Language: English
• Published: Cary, NC Oxford University Press 07.10.2009; Oxford Publishing Limited (England)
• Subjects: Adolescent; Adult; Age Distribution; Biological and medical sciences; Cancer; Carcinoma, Hepatocellular - epidemiology; Carcinoma, Hepatocellular - prevention & control; Child; Disease prevention; Female; Follow-Up Studies; Gastroenterology. Liver. Pancreas. Abdomen; Hepatitis; Hepatitis B; Hepatitis B e Antigens - blood; Hepatitis B Surface Antigens - blood; Hepatitis B Vaccines - administration & dosage; Hepatitis B virus; Humans; Incidence; Infections; Liver Neoplasms - epidemiology; Liver Neoplasms - prevention & control; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Mothers; Multivariate Analysis; Odds Ratio; Registries; Sex Distribution; Taiwan - epidemiology; Tropical medicine; Tumors; Vaccines; Young Adult; Asia; Taiwan; Human; Vaccination; Hepatic disease; Hepatocellular carcinoma; Malignant tumor; Epidemiology; Incidence; Infection; Viral hepatitis B; Prevention; Liver cancer; Immunoprophylaxis; Cancerology; Follow up study; Viral disease; Digestive diseases; Public health; Cancer

Background Hepatitis B virus (HBV) infection is a major cause of hepatocellular carcinoma. This population-based study aimed to investigate whether prevention of hepatocellular carcinoma by the universal Taiwanese HBV vaccine program, launched in July 1984, has extended beyond childhood and to ident...