Acceptability of Single-dose Clindamycin Gel for Bacterial Vaginosis: A Randomized Controlled Trial

• Published in: Clinical therapeutics Vol. 45; no. 5; pp. 415 - 425
• Main Authors: Mauck, Christine, Hillier, Sharon L., Gendreau, Judy, Dart, Clint, Wu, Hongsheng, Chavoustie, Steven, Sorkin-Wells, Valerie, Nicholson-Uhl, Clifton Scott, Perez, Brandon, Jacobs, Mark, Zack, Nadene, Friend, David
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2023; Elsevier Limited
• Subjects: Administration, Intravaginal; Anti-Bacterial Agents; Bacteria; bacterial vaginosis; bioadhesive; Clindamycin; Clindamycin - adverse effects; clindamycin gel; Condoms; Diaries; Dosage; Double-Blind Method; Female; Humans; Internal Medicine; Odor; Odors; Placebos; Pruritus; symptom resolution; treatment acceptability; Treatment Outcome; Vagina; Vaginal Creams, Foams, and Jellies - therapeutic use; Vaginosis; Vaginosis, Bacterial - diagnosis; Vaginosis, Bacterial - drug therapy; XACIATO; United States > US; clindamycin gel; treatment acceptability; bioadhesive; XACIATO; bacterial vaginosis; symptom resolution

The goal of this study was to assess the acceptability of a single-dose bioadhesive 2% clindamycin vaginal gel for bacterial vaginosis (BV). This double-blind, placebo-controlled, randomized study compared a new clindamycin gel with placebo gel (2:1 ratio). The primary objective was efficacy; second...