Remembrance of things PAS: regulation of development by bHLH–PAS proteins

Strange fits of passion I have known… (W Wordsworth, ‘Strange fits of passion’.) bHLH–PAS proteins are regulators of developmental and physiological events that are well conserved between vertebrates and invertebrates. Recent studies using mouse knockouts of bHLH–PAS genes have provided novel insigh...

Full description

Saved in:
Bibliographic Details
Published inCurrent Opinion in Genetics & Development Vol. 9; no. 5; pp. 580 - 587
Main Authors Crews, Stephen T, Fan, Chen-Ming
Format Book Review Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.1999
Subjects
Animals
Aryl hydrocarbon receptors
Cell Lineage
Drosophila
Drosophila - cytology
Drosophila - genetics
Helix-Loop-Helix Motifs
Homeostasis
Hypoxia
Mice
Oxygen - metabolism
PAS domain proteins
Protein Conformation
spineless gene
Transcription Factors - chemistry
Transcription Factors - physiology
Online AccessGet full text

Cover

Abstract Strange fits of passion I have known… (W Wordsworth, ‘Strange fits of passion’.) bHLH–PAS proteins are regulators of developmental and physiological events that are well conserved between vertebrates and invertebrates. Recent studies using mouse knockouts of bHLH–PAS genes have provided novel insight into the roles of hypoxia inducible factors in controlling oxygen-regulated development and homeostasis, and the role of Single-minded-1 in regulating development and transcription in the hypothalamus. The Drosophila spineless and vertebrate Aryl hydrocarbon receptor bHLH–PAS orthologs both function in chemosensory processes, but in fundamentally different ways. Spineless controls antennal, limb, and sensory cell development, whereas the Aryl hydrocarbon receptor regulates the response to toxin metabolism. Structural analyses of the PAS domain provide insight into how this interaction domain can act as ligand-binding environmental sensor and signal transducer.
AbstractList bHLH-PAS proteins are regulators of developmental and physiological events that are well conserved between vertebrates and invertebrates. Recent studies using mouse knockouts of bHLH-PAS genes have provided novel insight into the roles of hypoxia inducible factors in controlling oxygen-regulated development and homeostasis, and the role of Single-minded-1 in regulating development and transcription in the hypothalamus. The Drosophila spineless and vertebrate Aryl hydrocarbon receptor bHLH-PAS orthologs both function in chemosensory processes, but in fundamentally different ways. Spineless controls antennal, limb, and sensory cell development, whereas the Aryl hydrocarbon receptor regulates the response to toxin metabolism. Structural analyses of the PAS domain provide insight into how this interaction domain can act as ligand-binding environmental sensor and signal transducer.
Strange fits of passion I have knownellipsis (W Wordsworth, 'Strange fits of passion'.) bHLH-PAS proteins are regulators of developmental and physiological events that are well conserved between vertebrates and invertebrates. Recent studies using mouse knockouts of bHLH-PAS genes have provided novel insight into the roles of hypoxia inducible factors in controlling oxygen-regulated development and homeostasis, and the role of Single-minded-1 in regulating development and transcription in the hypothalamus. The Drosophila spineless and vertebrate Aryl hydrocarbon receptor bHLH-PAS orthologs both function in chemosensory processes, but in fundamentally different ways. Spineless controls antennal, limb, and sensory cell development, whereas the Aryl hydrocarbon receptor regulates the response to toxin metabolism. Structural analyses of the PAS domain provide insight into how this interaction domain can act as ligand-binding environmental sensor and signal transducer.
Strange fits of passion I have known… (W Wordsworth, ‘Strange fits of passion’.) bHLH–PAS proteins are regulators of developmental and physiological events that are well conserved between vertebrates and invertebrates. Recent studies using mouse knockouts of bHLH–PAS genes have provided novel insight into the roles of hypoxia inducible factors in controlling oxygen-regulated development and homeostasis, and the role of Single-minded-1 in regulating development and transcription in the hypothalamus. The Drosophila spineless and vertebrate Aryl hydrocarbon receptor bHLH–PAS orthologs both function in chemosensory processes, but in fundamentally different ways. Spineless controls antennal, limb, and sensory cell development, whereas the Aryl hydrocarbon receptor regulates the response to toxin metabolism. Structural analyses of the PAS domain provide insight into how this interaction domain can act as ligand-binding environmental sensor and signal transducer.
Author Fan, Chen-Ming
Crews, Stephen T
Author_xml – sequence: 1
  givenname: Stephen T
  surname: Crews
  fullname: Crews, Stephen T
  email: steve_crews@unc.edu
  organization: Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7260, USA
– sequence: 2
  givenname: Chen-Ming
  surname: Fan
  fullname: Fan, Chen-Ming
  email: fan@mail1.ciwemb.edu
  organization: Carnegie Institute of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/10508688$$D View this record in MEDLINE/PubMed
BookMark eNqFkM1KAzEQx4NUtH48grIn0cNqZrO7SbxIEbViQfEDvIVNdloj-1GTreDNd_ANfRJTW8Rb5zKH-c38h98W6TVtg4TsAT0GCvnJA5WZjFPGnw-lPKKhWCzXSB8ElzFlgvZI_w_ZJFvevwYmAcg3yCbQjIpciD65uccaa-2KxmDUjqPuxTYTH90NHk4jh5NZVXS2beaTEt-xaqc1Nl2kPyI9HA2_P78CGE1d26Ft_A5ZHxeVx91l3yZPlxeP58N4dHt1fT4YxSYD2sU5Z8AFHac8lVmGFHjCjJaYMMgYK4FpU5SpSMN_MocsZ0zLhBaaogBtTMq2ycHibgh-m6HvVG29waoqGmxnXnHKJSSCrgSBBzkSRACzBWhc673DsZo6WxfuQwFVc93qV7eau1RSql_dSoa9_WXATNdY_tta-A3A2QLA4OPdolPeWAyuS-vQdKps7YqIH5uuj_Y
CitedBy_id crossref_primary_10_1016_j_schres_2010_04_002
crossref_primary_10_1016_j_abb_2003_10_005
crossref_primary_10_1016_j_bcp_2008_08_031
crossref_primary_10_1038_sj_onc_1206238
crossref_primary_10_1074_jbc_M110752200
crossref_primary_10_1016_j_neuro_2010_03_007
crossref_primary_10_1371_journal_pone_0179545
crossref_primary_10_1002_dneu_22330
crossref_primary_10_1006_dbio_2001_0174
crossref_primary_10_1016_j_ydbio_2013_05_015
crossref_primary_10_1172_JCI200318181
crossref_primary_10_1016_j_devcel_2013_02_016
crossref_primary_10_1016_j_pep_2008_10_005
crossref_primary_10_1007_s00427_004_0462_9
crossref_primary_10_3390_ijms161226144
crossref_primary_10_1002_ajmg_a_35334
crossref_primary_10_1038_sj_onc_1207202
crossref_primary_10_1128_MCB_00236_08
crossref_primary_10_1002_jbt_10051
crossref_primary_10_1016_j_molbrainres_2004_06_023
crossref_primary_10_1074_jbc_M307832200
crossref_primary_10_1091_mbc_12_2_407
crossref_primary_10_3390_ijms24098320
crossref_primary_10_1002_jcb_21376
crossref_primary_10_1111_j_1432_0436_2008_00285_x
crossref_primary_10_1128_MCB_22_12_4147_4157_2002
crossref_primary_10_1006_bbrc_2001_6309
crossref_primary_10_1046_j_1460_9568_2002_01894_x
crossref_primary_10_1097_01_WCB_0000110532_48786_46
crossref_primary_10_1002_neu_10164
crossref_primary_10_1152_jappl_2000_88_4_1474
crossref_primary_10_1074_jbc_M512145200
crossref_primary_10_1016_j_toxrep_2021_11_017
crossref_primary_10_1016_S0014_2999_00_00541_0
crossref_primary_10_1046_j_1525_142X_2002_02023_x
crossref_primary_10_1515_BC_2006_144
crossref_primary_10_1016_S0925_4773_01_00488_9
crossref_primary_10_1016_j_taap_2006_12_002
crossref_primary_10_1128_MCB_22_19_6842_6853_2002
crossref_primary_10_1177_002215540305100407
crossref_primary_10_1016_j_bbagrm_2009_06_003
crossref_primary_10_1177_107385840100700606
crossref_primary_10_1002_em_20310
crossref_primary_10_1016_j_ydbio_2009_03_001
crossref_primary_10_1016_S1011_1344_00_00004_X
crossref_primary_10_1080_10409230091169186
crossref_primary_10_1002_bies_10333
crossref_primary_10_1124_dmd_107_016253
crossref_primary_10_3389_fimmu_2022_797815
crossref_primary_10_1021_tx7001965
crossref_primary_10_1074_jbc_M808479200
crossref_primary_10_1016_j_bbaexp_2006_11_008
crossref_primary_10_1016_j_brainres_2006_11_083
crossref_primary_10_1006_mgme_2000_3074
crossref_primary_10_1242_dev_00959
crossref_primary_10_1128_MCB_01701_07
crossref_primary_10_1016_j_ydbio_2004_02_004
crossref_primary_10_1074_jbc_M310041200
crossref_primary_10_1210_me_2003_0372
crossref_primary_10_1074_jbc_C000484200
crossref_primary_10_1093_nar_gkn247
crossref_primary_10_1016_S1471_4914_01_02090_1
crossref_primary_10_1074_jbc_M303644200
crossref_primary_10_1074_jbc_M508858200
crossref_primary_10_1016_j_gene_2009_08_003
crossref_primary_10_1074_jbc_M101041200
crossref_primary_10_1128_MCB_01027_07
crossref_primary_10_1186_1471_2164_12_333
crossref_primary_10_1038_onc_2012_509
crossref_primary_10_1016_S1357_2725_03_00211_5
crossref_primary_10_1016_j_tins_2016_02_003
crossref_primary_10_1021_cr000243
crossref_primary_10_1128_EC_00026_07
crossref_primary_10_1101_gad_14_10_1209
crossref_primary_10_1016_j_tox_2008_01_002
crossref_primary_10_1074_jbc_M402168200
crossref_primary_10_1016_j_str_2017_05_008
crossref_primary_10_1371_journal_pone_0058914
crossref_primary_10_1016_j_bbrc_2006_02_187
crossref_primary_10_1016_j_bbagrm_2009_01_003
crossref_primary_10_1006_abbi_2001_2440
crossref_primary_10_1016_j_ajpath_2011_03_044
crossref_primary_10_1093_toxsci_kfj215
crossref_primary_10_1002_ps_5316
crossref_primary_10_3390_ijms20153653
crossref_primary_10_1128_MMBR_66_2_300_372_2002
crossref_primary_10_1016_S0925_4773_00_00468_8
crossref_primary_10_1111_j_1742_4658_2008_06686_x
crossref_primary_10_1074_jbc_M108132200
crossref_primary_10_1038_s41437_018_0173_z
crossref_primary_10_1073_pnas_170301897
crossref_primary_10_1242_dev_128_12_2233
crossref_primary_10_1186_s13041_016_0207_5
crossref_primary_10_1098_rstb_2001_0965
crossref_primary_10_54097_hset_v8i_1236
crossref_primary_10_1016_j_ygeno_2005_01_010
crossref_primary_10_1093_genetics_165_4_1971
crossref_primary_10_1111_j_1460_9568_2005_04291_x
crossref_primary_10_1074_jbc_M105261200
crossref_primary_10_1016_j_gene_2007_06_005
crossref_primary_10_1093_toxsci_kfu027
crossref_primary_10_1073_pnas_121494298
crossref_primary_10_3390_biology12040526
crossref_primary_10_1016_j_yexcr_2009_11_008
crossref_primary_10_1158_0008_5472_CAN_09_3090
crossref_primary_10_1016_j_ydbio_2014_12_020
crossref_primary_10_1007_s10528_009_9252_4
crossref_primary_10_1371_journal_pcbi_1006021
crossref_primary_10_1016_j_aquatox_2004_03_019
crossref_primary_10_1242_dev_201566
crossref_primary_10_1021_bi801487x
crossref_primary_10_1371_journal_pone_0155105
crossref_primary_10_1124_mol_107_039305
crossref_primary_10_1152_japplphysiol_00904_2002
crossref_primary_10_1006_bbrc_2000_3248
crossref_primary_10_1016_j_bbrc_2016_03_111
crossref_primary_10_1002_dvdy_24229
crossref_primary_10_1242_dev_127_21_4701
crossref_primary_10_1523_JNEUROSCI_20_12_04596_2000
crossref_primary_10_1128_JB_186_20_6782_6791_2004
crossref_primary_10_1016_j_tem_2014_11_002
crossref_primary_10_1289_ehp_0800485
crossref_primary_10_1006_abbi_2001_2339
crossref_primary_10_1152_physrev_2001_81_4_1535
crossref_primary_10_1016_j_febslet_2008_06_033
crossref_primary_10_1016_j_gene_2005_05_026
crossref_primary_10_1038_sj_onc_1205094
crossref_primary_10_1007_s00427_010_0339_z
crossref_primary_10_1073_pnas_0703719104
crossref_primary_10_1074_jbc_M805196200
crossref_primary_10_1111_j_1439_0264_2010_01059_x
crossref_primary_10_1577_H08_001_1
crossref_primary_10_1016_j_mrfmmm_2004_09_006
crossref_primary_10_1242_dev_033878
crossref_primary_10_1074_jbc_M304489200
Cites_doi 10.1006/abbi.1994.1160
10.1016/0378-1119(96)00060-1
10.1006/bbrc.1998.9012
10.1242/dev.125.9.1599
10.1016/S0960-9822(99)80257-7
10.1242/dev.125.20.3989
10.1074/jbc.272.13.8581
10.1101/gad.11.1.72
10.1016/S0925-4773(96)00559-X
10.1006/dbio.1995.1283
10.1038/386403a0
10.1073/pnas.95.11.5884
10.1073/pnas.92.12.5510
10.1006/bbrc.1998.9234
10.1101/gad.12.9.1290
10.1038/19315
10.1101/gr.7.6.569
10.1073/pnas.95.6.2844
10.1073/pnas.93.13.6731
10.1016/S0092-8674(00)80176-2
10.1242/dev.120.12.3563
10.1016/S0092-8674(00)81635-9
10.1006/dbio.1997.8758
10.3109/10408449709021615
10.1073/pnas.95.26.15177
10.1006/dbio.1999.9253
10.1093/emboj/17.11.3005
10.1007/BF00020457
10.1016/S0968-0004(97)01110-9
10.1038/28867
10.1101/gad.12.5.607
10.1016/S0092-8674(00)80959-9
10.1242/dev.124.22.4571
10.1101/gad.9.1.123
10.1021/bi00019a004
10.1038/380439a0
10.1101/gad.10.1.93
10.1242/dev.124.20.3975
10.1006/geno.1998.5347
10.1016/0196-9781(94)90081-7
10.1242/dev.126.17.3937
10.1101/gad.12.2.149
10.1006/mcne.1996.0001
10.1016/S0960-9822(06)00352-6
10.1016/S0959-437X(98)80016-6
10.1016/0014-5793(96)00484-X
10.1073/pnas.94.2.713
10.1016/S0169-328X(97)00074-0
10.1073/pnas.95.10.5474
10.1126/science.7732381
10.1101/gad.10.1.103
10.1101/gad.12.21.3320
10.1016/S0022-1910(96)00084-4
10.1101/gad.12.20.3264
10.1016/S0092-8674(00)80566-8
10.1038/380435a0
ContentType Book Review
Journal Article
Copyright 1999 Elsevier Science Ltd
Copyright_xml – notice: 1999 Elsevier Science Ltd
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7SS
8FD
FR3
P64
RC3
7X8
DOI 10.1016/S0959-437X(99)00003-9
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Entomology Abstracts (Full archive)
Technology Research Database
Engineering Research Database
Biotechnology and BioEngineering Abstracts
Genetics Abstracts
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Entomology Abstracts
Genetics Abstracts
Engineering Research Database
Technology Research Database
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
DatabaseTitleList Entomology Abstracts
MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1879-0380
EndPage 587
ExternalDocumentID 10_1016_S0959_437X_99_00003_9
10508688
S0959437X99000039
Genre Research Support, U.S. Gov't, Non-P.H.S
Research Support, U.S. Gov't, P.H.S
Review
Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
--K
--M
-DZ
-~X
.1-
.FO
.GJ
.~1
0R~
1B1
1P~
1RT
1~.
1~5
29F
4.4
457
4G.
53G
5GY
5VS
7-5
71M
8P~
9JM
AABNK
AACTN
AAEDT
AAEDW
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AAXUO
ABEFU
ABFRF
ABGSF
ABJNI
ABLJU
ABMAC
ABUDA
ABXDB
ABYKQ
ACDAQ
ACGFS
ACRLP
ADBBV
ADEZE
ADMUD
ADUVX
AEBSH
AEFWE
AEHWI
AEKER
AENEX
AEVXI
AFCTW
AFKWA
AFRHN
AFTJW
AFXIZ
AGHFR
AGHSJ
AGRDE
AGUBO
AGYEJ
AHHHB
AIEXJ
AIKHN
AITUG
AJBFU
AJOXV
AJUYK
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLXMC
CAG
COF
CS3
DOVZS
EBS
EFJIC
EFLBG
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-2
G-Q
GBLVA
HLW
HVGLF
HX~
HZ~
IHE
J1W
KOM
LX3
M41
MO0
N9A
O-L
O9-
O9.
OAUVE
OK~
OZT
P-8
P-9
P2P
PC.
Q38
R2-
RIG
ROL
RPZ
SBG
SCC
SDF
SDG
SDP
SES
SEW
SPCBC
SSU
SSZ
T5K
WUQ
Y6R
Z5R
ZA5
ZGI
~G-
AAXKI
AFJKZ
AKRWK
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7SS
8FD
FR3
P64
RC3
7X8
ID FETCH-LOGICAL-c510t-6731780f474955e01723cb9e231533d13bcad4846889615633b920ab0e81bcc43
IEDL.DBID AIKHN
ISSN 0959-437X
IngestDate Thu Aug 15 22:27:58 EDT 2024
Sat Aug 17 03:10:37 EDT 2024
Thu Sep 26 18:46:50 EDT 2024
Sat Sep 28 07:34:48 EDT 2024
Fri Feb 23 02:24:19 EST 2024
IsPeerReviewed true
IsScholarly true
Issue 5
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c510t-6731780f474955e01723cb9e231533d13bcad4846889615633b920ab0e81bcc43
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ObjectType-Article-1
ObjectType-Feature-3
ObjectType-Review-2
PMID 10508688
PQID 17437918
PQPubID 23462
PageCount 8
ParticipantIDs proquest_miscellaneous_70791280
proquest_miscellaneous_17437918
crossref_primary_10_1016_S0959_437X_99_00003_9
pubmed_primary_10508688
elsevier_sciencedirect_doi_10_1016_S0959_437X_99_00003_9
PublicationCentury 1900
PublicationDate 1999-10-01
PublicationDateYYYYMMDD 1999-10-01
PublicationDate_xml – month: 10
  year: 1999
  text: 1999-10-01
  day: 01
PublicationDecade 1990
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Current Opinion in Genetics & Development
PublicationTitleAlternate Curr Opin Genet Dev
PublicationYear 1999
Publisher Elsevier Ltd
Publisher_xml – name: Elsevier Ltd
References Hogenesch, Gu, Jain, Bradfield (BIB19) 1998; 95
Isaac, Andrew (BIB34) 1996; 10
Zhulin, Taylor, Dixon (BIB3) 1997; 22
Ward, Mosher, Crews (BIB36) 1998; 125
Nagao, Ebert, Ratcliffe, Pugh (BIB38) 1996; 387
Hogenesch, Chan, Kackiw, Brown, Gu, Pray-Grant, Perdew, Bradfield (BIB17) 1997; 272
Rowlands, Gustafsson (BIB52) 1997; 27
Kozak, Abbott, Hankinson (BIB24) 1997; 191
Maltepe, Schmidt, Baunoch, Bradfield, Simon (BIB23) 1997; 386
Semenza (BIB11) 1998; 8
Takahata, Sogawa, Kobayashi, Ema, Mimura, Ozaki, Fujii-Kuriyama (BIB18) 1998; 248
Wharton, Franks, Kasai, Crews (BIB47) 1994; 120
Krishnan, Sun, Mohsenin, Wyman, Haddad (BIB30) 1997; 43
Zhou, Barnard, Tian, Ring, Francke, Shelton, Richardson, Russell, McKnight (BIB16) 1997; 94
Fan, Kuwana, Bulfone, Fletcher, Copeland, Jenkins, Crews, Martinez, Puelles, Rubenstein, Tessier-Lavigne (BIB42) 1996; 7
Wang, Jiang, Rue, Semenza (BIB13) 1995; 92
Ohshiro, Saigo (BIB37) 1997; 124
Sanchez-Soriano, Russell (BIB48) 1998; 125
Dunlap (BIB5) 1999; 96
Iyer, Kotch, Agani, Leung, Laughner, Wenger, Gassmann, Gerhart, Lawler, Yu, Semenza (BIB20) 1998; 12
Mellerick, Nirenberg (BIB50) 1995; 171
Michaud, Fan (BIB41) 1997; 7
Pellequer, Wager-Smith, Kay, Getzoff (BIB10) 1998; 95
Borgstahl, Williams, Getzoff (BIB6) 1995; 34
Patel, Chung, Kay, Mallet, Gibbon, Thompson, Bacon, Coast (BIB44) 1994; 15
Fernandez-Salguero, Pineau, Hilbert, McPhail, Lee, Kimura, Nebert, Rudikoff, Ward, Gonzalez (BIB57) 1995; 268
Nambu, Chen, Hu, Crews (BIB39) 1996; 172
Carmeliet, Dor, Herbert, Fukumura, Brusselmans, Dewerchin, Neeman, Bono, Abramovitch, Maxwell (BIB22) 1998; 394
Ferrara, Carver-Moore, Chen, Dowd, Lu, O’Shea, Powell-Braxton, Hillan, Moore (BIB28) 1996; 380
Xiao, Hrdlicka, Nambu (BIB51) 1996; 58
Emmons, Duncan, Estes, Mosher, Sonnenfeld Ward, Duncan, Crews (BIB56) 1999; 26
Carmeliet, Ferreira, Breier, Pollefeyt, Kieckens, Gertsenstein, Fahrig, Vandenhoeck, Harpal, Eberhardt (BIB27) 1996; 380
Sonnenfeld, Ward, Nystrom, Mosher, Stahl, Crews (BIB35) 1997; 124
Michaud, Rosenquist, May, Fan (BIB43) 1998; 12
Guillemin, Krasnow (BIB12) 1997; 89
Duncan, Burgess, Duncan (BIB54) 1998; 12
Wines, Tiffany, Holdener (BIB26) 1998; 51
Ryan, Lo, Johnson (BIB21) 1998; 17
Crews (BIB1) 1998; 12
Kotch, Iyer, Laughner, Semenza (BIB25) 1999; 209
Tian, McKnight, Russell (BIB14) 1997; 11
Schmidt, Su, Reddy, Simon, Bradfield (BIB58) 1996; 93
Pellequer, Brudler, Getzoff (BIB9) 1999; 9
Hahn, Poland, Glover, Stegement (BIB53) 1994; 310
Lagarias, Wu, Lagarias (BIB2) 1995; 29
Tian, Hammer, Matsumoto, Russell, McKnight (BIB29) 1998; 12
Gong, Hao, Mansy, Gonzalez, Gilles-Gonzalez, Chan (BIB7) 1998; 95
Ma, Haddad (BIB32) 1997; 46
Anderson, Perkins, Chittick, Shrigley, Johnson (BIB45) 1995; 9
Wigglesworth (BIB31) 1954; 95
Gu, Moran, Hogenesch, Wartman, Bradfield (BIB15) 1998; 7
Ponting, Aravind (BIB4) 1997; 7
Jin, Shearman, Weaver, Zylka, de Vries, Reppert (BIB46) 1999; 96
Powell-Coffman, Bradfield, Wood (BIB55) 1998; 95
Wilk, Weizman, Glazer, Shilo (BIB33) 1996; 10
Bacon, Wappner, O’Rourke, Bartlett, Shilo, Pugh, Ratcliffe (BIB40) 1998; 249
Briscoe, Sussel, Hartigan-O’Connor, Jessell, Rubenstein, Ericson (BIB49) 1999; 398
Cabral, Lee, Cohen, Chait, Li, Mackinnon (BIB8) 1998; 95
Zhulin (10.1016/S0959-437X(99)00003-9_BIB3) 1997; 22
Schmidt (10.1016/S0959-437X(99)00003-9_BIB58) 1996; 93
Powell-Coffman (10.1016/S0959-437X(99)00003-9_BIB55) 1998; 95
Wigglesworth (10.1016/S0959-437X(99)00003-9_BIB31) 1954; 95
Fan (10.1016/S0959-437X(99)00003-9_BIB42) 1996; 7
Patel (10.1016/S0959-437X(99)00003-9_BIB44) 1994; 15
Cabral (10.1016/S0959-437X(99)00003-9_BIB8) 1998; 95
Wang (10.1016/S0959-437X(99)00003-9_BIB13) 1995; 92
Hogenesch (10.1016/S0959-437X(99)00003-9_BIB19) 1998; 95
Ma (10.1016/S0959-437X(99)00003-9_BIB32) 1997; 46
Iyer (10.1016/S0959-437X(99)00003-9_BIB20) 1998; 12
Krishnan (10.1016/S0959-437X(99)00003-9_BIB30) 1997; 43
Gong (10.1016/S0959-437X(99)00003-9_BIB7) 1998; 95
Hogenesch (10.1016/S0959-437X(99)00003-9_BIB17) 1997; 272
Hahn (10.1016/S0959-437X(99)00003-9_BIB53) 1994; 310
Pellequer (10.1016/S0959-437X(99)00003-9_BIB9) 1999; 9
Nambu (10.1016/S0959-437X(99)00003-9_BIB39) 1996; 172
Rowlands (10.1016/S0959-437X(99)00003-9_BIB52) 1997; 27
Michaud (10.1016/S0959-437X(99)00003-9_BIB41) 1997; 7
Emmons (10.1016/S0959-437X(99)00003-9_BIB56) 1999; 26
Crews (10.1016/S0959-437X(99)00003-9_BIB1) 1998; 12
Isaac (10.1016/S0959-437X(99)00003-9_BIB34) 1996; 10
Briscoe (10.1016/S0959-437X(99)00003-9_BIB49) 1999; 398
Xiao (10.1016/S0959-437X(99)00003-9_BIB51) 1996; 58
Sanchez-Soriano (10.1016/S0959-437X(99)00003-9_BIB48) 1998; 125
Jin (10.1016/S0959-437X(99)00003-9_BIB46) 1999; 96
Ryan (10.1016/S0959-437X(99)00003-9_BIB21) 1998; 17
Duncan (10.1016/S0959-437X(99)00003-9_BIB54) 1998; 12
Kozak (10.1016/S0959-437X(99)00003-9_BIB24) 1997; 191
Pellequer (10.1016/S0959-437X(99)00003-9_BIB10) 1998; 95
Kotch (10.1016/S0959-437X(99)00003-9_BIB25) 1999; 209
Wines (10.1016/S0959-437X(99)00003-9_BIB26) 1998; 51
Lagarias (10.1016/S0959-437X(99)00003-9_BIB2) 1995; 29
Wharton (10.1016/S0959-437X(99)00003-9_BIB47) 1994; 120
Anderson (10.1016/S0959-437X(99)00003-9_BIB45) 1995; 9
Michaud (10.1016/S0959-437X(99)00003-9_BIB43) 1998; 12
Ohshiro (10.1016/S0959-437X(99)00003-9_BIB37) 1997; 124
Ponting (10.1016/S0959-437X(99)00003-9_BIB4) 1997; 7
Zhou (10.1016/S0959-437X(99)00003-9_BIB16) 1997; 94
Wilk (10.1016/S0959-437X(99)00003-9_BIB33) 1996; 10
Bacon (10.1016/S0959-437X(99)00003-9_BIB40) 1998; 249
Ferrara (10.1016/S0959-437X(99)00003-9_BIB28) 1996; 380
Takahata (10.1016/S0959-437X(99)00003-9_BIB18) 1998; 248
Tian (10.1016/S0959-437X(99)00003-9_BIB14) 1997; 11
Gu (10.1016/S0959-437X(99)00003-9_BIB15) 1998; 7
Dunlap (10.1016/S0959-437X(99)00003-9_BIB5) 1999; 96
Semenza (10.1016/S0959-437X(99)00003-9_BIB11) 1998; 8
Maltepe (10.1016/S0959-437X(99)00003-9_BIB23) 1997; 386
Sonnenfeld (10.1016/S0959-437X(99)00003-9_BIB35) 1997; 124
Borgstahl (10.1016/S0959-437X(99)00003-9_BIB6) 1995; 34
Carmeliet (10.1016/S0959-437X(99)00003-9_BIB27) 1996; 380
Fernandez-Salguero (10.1016/S0959-437X(99)00003-9_BIB57) 1995; 268
Nagao (10.1016/S0959-437X(99)00003-9_BIB38) 1996; 387
Carmeliet (10.1016/S0959-437X(99)00003-9_BIB22) 1998; 394
Tian (10.1016/S0959-437X(99)00003-9_BIB29) 1998; 12
Mellerick (10.1016/S0959-437X(99)00003-9_BIB50) 1995; 171
Guillemin (10.1016/S0959-437X(99)00003-9_BIB12) 1997; 89
Ward (10.1016/S0959-437X(99)00003-9_BIB36) 1998; 125
References_xml – volume: 27
  start-page: 109
  year: 1997
  end-page: 134
  ident: BIB52
  article-title: Aryl hydrocarbon receptor-mediated signal transduction
  publication-title: Crit Rev Toxicol
  contributor:
    fullname: Gustafsson
– volume: 46
  start-page: 325
  year: 1997
  end-page: 328
  ident: BIB32
  article-title: Anoxia regulates gene expression in the central nervous system of
  publication-title: Mol Brain Res
  contributor:
    fullname: Haddad
– volume: 125
  start-page: 1599
  year: 1998
  end-page: 1608
  ident: BIB36
  article-title: Regulation of
  publication-title: Development
  contributor:
    fullname: Crews
– volume: 191
  start-page: 297
  year: 1997
  end-page: 305
  ident: BIB24
  article-title: ARNT-deficient mice and placental differentiation
  publication-title: Dev Biol
  contributor:
    fullname: Hankinson
– volume: 29
  start-page: 1127
  year: 1995
  end-page: 1142
  ident: BIB2
  article-title: Atypical phytochrome gene structure in the green alga
  publication-title: Plant Mol Biol
  contributor:
    fullname: Lagarias
– volume: 95
  start-page: 15177
  year: 1998
  end-page: 15182
  ident: BIB7
  article-title: Structure of a biological oxygen sensor: a new mechanism for heme-driven signal transduction
  publication-title: Proc Natl Acad Sci USA
  contributor:
    fullname: Chan
– volume: 17
  start-page: 3005
  year: 1998
  end-page: 3015
  ident: BIB21
  article-title: HIF-1α is required for solid tumor formation and embryonic vascularization
  publication-title: EMBO J
  contributor:
    fullname: Johnson
– volume: 94
  start-page: 713
  year: 1997
  end-page: 718
  ident: BIB16
  article-title: Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system
  publication-title: Proc Natl Acad Sci USA
  contributor:
    fullname: McKnight
– volume: 248
  start-page: 789
  year: 1998
  end-page: 794
  ident: BIB18
  article-title: Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1α, HLF, and Clock
  publication-title: Biochem Biophys Res Commun
  contributor:
    fullname: Fujii-Kuriyama
– volume: 172
  start-page: 249
  year: 1996
  end-page: 254
  ident: BIB39
  article-title: The
  publication-title: Gene
  contributor:
    fullname: Crews
– volume: 249
  start-page: 811
  year: 1998
  end-page: 816
  ident: BIB40
  article-title: Regulation of the
  publication-title: Biochem Biophys Res Comm
  contributor:
    fullname: Ratcliffe
– volume: 398
  start-page: 622
  year: 1999
  end-page: 627
  ident: BIB49
  article-title: Homeobox gene
  publication-title: Nature
  contributor:
    fullname: Ericson
– volume: 93
  start-page: 6731
  year: 1996
  end-page: 6736
  ident: BIB58
  article-title: Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development
  publication-title: Proc Natl Acad Sci USA
  contributor:
    fullname: Bradfield
– volume: 89
  start-page: 9
  year: 1997
  end-page: 12
  ident: BIB12
  article-title: The hypoxic response: huffing and HIFing
  publication-title: Cell
  contributor:
    fullname: Krasnow
– volume: 387
  start-page: 161
  year: 1996
  end-page: 166
  ident: BIB38
  article-title:
  publication-title: FEBS Lett
  contributor:
    fullname: Pugh
– volume: 386
  start-page: 403
  year: 1997
  end-page: 407
  ident: BIB23
  article-title: Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
  publication-title: Nature
  contributor:
    fullname: Simon
– volume: 95
  start-page: 5474
  year: 1998
  end-page: 5479
  ident: BIB19
  article-title: The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors
  publication-title: Proc Natl Acad Sci USA
  contributor:
    fullname: Bradfield
– volume: 310
  start-page: 218
  year: 1994
  end-page: 228
  ident: BIB53
  article-title: Photoaffinity labeling of the Ah receptor: phylogenetic survey of diverse vertebrate and invertebrate species
  publication-title: Arch Biochem Biophys
  contributor:
    fullname: Stegement
– volume: 209
  start-page: 254
  year: 1999
  end-page: 267
  ident: BIB25
  article-title: Defective vascularization of HIF-1α-null embryos is not associated with VEGF deficiency but with mesenchymal cell death
  publication-title: Dev Biol
  contributor:
    fullname: Semenza
– volume: 120
  start-page: 3563
  year: 1994
  end-page: 3569
  ident: BIB47
  article-title: Control of CNS midline transcription by asymmetric E-box elements: similarity to xenobiotic responsive regulation
  publication-title: Development
  contributor:
    fullname: Crews
– volume: 43
  start-page: 203
  year: 1997
  end-page: 210
  ident: BIB30
  article-title: Behavioral and electrophysiologic responses of
  publication-title: J Insect Physiol
  contributor:
    fullname: Haddad
– volume: 9
  start-page: 416
  year: 1999
  end-page: 4180
  ident: BIB9
  article-title: Biological sensors: more than one way to sense oxygen
  publication-title: Curr Biol
  contributor:
    fullname: Getzoff
– volume: 95
  start-page: 115
  year: 1954
  end-page: 137
  ident: BIB31
  article-title: Growth and regeneration in the tracheal system of an insect,
  publication-title: Q J Microsc Sci
  contributor:
    fullname: Wigglesworth
– volume: 12
  start-page: 3264
  year: 1998
  end-page: 3275
  ident: BIB43
  article-title: Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1
  publication-title: Genes Dev
  contributor:
    fullname: Fan
– volume: 92
  start-page: 5510
  year: 1995
  end-page: 5514
  ident: BIB13
  article-title: Hypoxia-inducible factor 1 is a basic helix-loop-helix-PAS heterodimer regulated by cellular O
  publication-title: Proc Natl Acad Sci USA
  contributor:
    fullname: Semenza
– volume: 95
  start-page: 5884
  year: 1998
  end-page: 5890
  ident: BIB10
  article-title: Photoactive yellow protein: a structural prototype for the three-dimensional fold of the PAS domain superfamily
  publication-title: Proc Natl Acad Sci USA
  contributor:
    fullname: Getzoff
– volume: 380
  start-page: 439
  year: 1996
  end-page: 442
  ident: BIB28
  article-title: Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
  publication-title: Nature
  contributor:
    fullname: Moore
– volume: 34
  start-page: 6278
  year: 1995
  end-page: 6287
  ident: BIB6
  article-title: 1.4 Å structure of photoactive yellow protein, a cytosolic photoreceptor: unusual fold, active site, and chromophore
  publication-title: Biochemistry
  contributor:
    fullname: Getzoff
– volume: 95
  start-page: 649
  year: 1998
  end-page: 655
  ident: BIB8
  article-title: Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain
  publication-title: Cell
  contributor:
    fullname: Mackinnon
– volume: 7
  start-page: 205
  year: 1998
  end-page: 213
  ident: BIB15
  article-title: Molecular characterization and chromosomal localization of a third a-class hypoxia inducible factor subunit, HIF3α
  publication-title: Gene Expression
  contributor:
    fullname: Bradfield
– volume: 125
  start-page: 3989
  year: 1998
  end-page: 3996
  ident: BIB48
  article-title: The
  publication-title: Development
  contributor:
    fullname: Russell
– volume: 7
  start-page: 569
  year: 1997
  end-page: 571
  ident: BIB41
  article-title:
  publication-title: Genome Research
  contributor:
    fullname: Fan
– volume: 171
  start-page: 306
  year: 1995
  end-page: 316
  ident: BIB50
  article-title: Dorsal-ventral patterning genes restrict NK-2 homeobox gene expression to the ventral half of the central nervous system of
  publication-title: Dev Biol
  contributor:
    fullname: Nirenberg
– volume: 12
  start-page: 607
  year: 1998
  end-page: 620
  ident: BIB1
  article-title: Control of cell lineage-specific development and transcription by bHLH-PAS proteins
  publication-title: Genes Dev
  contributor:
    fullname: Crews
– volume: 12
  start-page: 149
  year: 1998
  end-page: 162
  ident: BIB20
  article-title: Cellular and developmental control of O
  publication-title: Genes Dev
  contributor:
    fullname: Semenza
– volume: 12
  start-page: 1290
  year: 1998
  end-page: 1303
  ident: BIB54
  article-title: Control of distal antennal identity and tarsal development in
  publication-title: Genes Dev
  contributor:
    fullname: Duncan
– volume: 9
  start-page: 123
  year: 1995
  end-page: 137
  ident: BIB45
  article-title:
  publication-title: Genes Dev
  contributor:
    fullname: Johnson
– volume: 124
  start-page: 3975
  year: 1997
  end-page: 3986
  ident: BIB37
  article-title: Transcriptional regulation of
  publication-title: Development
  contributor:
    fullname: Saigo
– volume: 124
  start-page: 4583
  year: 1997
  end-page: 4594
  ident: BIB35
  article-title: The
  publication-title: Development
  contributor:
    fullname: Crews
– volume: 8
  start-page: 588
  year: 1998
  end-page: 594
  ident: BIB11
  article-title: Hypoxia-inducible factor 1: master regulator of O
  publication-title: Curr Opin Genet Dev
  contributor:
    fullname: Semenza
– volume: 272
  start-page: 8581
  year: 1997
  end-page: 8593
  ident: BIB17
  article-title: Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
  publication-title: J Biol Chem
  contributor:
    fullname: Bradfield
– volume: 58
  start-page: 65
  year: 1996
  end-page: 74
  ident: BIB51
  article-title: Alternate function of the
  publication-title: Mech Dev
  contributor:
    fullname: Nambu
– volume: 51
  start-page: 223
  year: 1998
  end-page: 232
  ident: BIB26
  article-title: Physical localization of the mouse
  publication-title: Genomics
  contributor:
    fullname: Holdener
– volume: 96
  start-page: 57
  year: 1999
  end-page: 68
  ident: BIB46
  article-title: A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock
  publication-title: Cell
  contributor:
    fullname: Reppert
– volume: 380
  start-page: 435
  year: 1996
  end-page: 439
  ident: BIB27
  article-title: Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
  publication-title: Nature
  contributor:
    fullname: Eberhardt
– volume: 96
  start-page: 271
  year: 1999
  end-page: 290
  ident: BIB5
  article-title: Molecular bases for circadian clocks
  publication-title: Cell
  contributor:
    fullname: Dunlap
– volume: 95
  start-page: 2844
  year: 1998
  end-page: 2849
  ident: BIB55
  article-title:
  publication-title: Proc Natl Acad Sci USA
  contributor:
    fullname: Wood
– volume: 394
  start-page: 485
  year: 1998
  end-page: 490
  ident: BIB22
  article-title: Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
  publication-title: Nature
  contributor:
    fullname: Maxwell
– volume: 15
  start-page: 591
  year: 1994
  end-page: 602
  ident: BIB44
  article-title: Localization of
  publication-title: Peptides
  contributor:
    fullname: Coast
– volume: 26
  start-page: 3937
  year: 1999
  end-page: 3945
  ident: BIB56
  article-title: The
  publication-title: Development
  contributor:
    fullname: Crews
– volume: 7
  start-page: 1
  year: 1996
  end-page: 16
  ident: BIB42
  article-title: Expression patterns of two murine homologs of
  publication-title: Mol Cell Neuro
  contributor:
    fullname: Tessier-Lavigne
– volume: 268
  start-page: 722
  year: 1995
  end-page: 726
  ident: BIB57
  article-title: Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor
  publication-title: Science
  contributor:
    fullname: Gonzalez
– volume: 10
  start-page: 93
  year: 1996
  end-page: 102
  ident: BIB33
  article-title:
  publication-title: Genes Dev
  contributor:
    fullname: Shilo
– volume: 7
  start-page: 674
  year: 1997
  end-page: 677
  ident: BIB4
  article-title: PAS: a multifunctional domain family comes to light
  publication-title: Curr Biol
  contributor:
    fullname: Aravind
– volume: 12
  start-page: 3320
  year: 1998
  end-page: 3324
  ident: BIB29
  article-title: The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
  publication-title: Genes Dev
  contributor:
    fullname: McKnight
– volume: 10
  start-page: 103
  year: 1996
  end-page: 117
  ident: BIB34
  article-title: Tubulogenesis in
  publication-title: Genes Dev
  contributor:
    fullname: Andrew
– volume: 22
  start-page: 331
  year: 1997
  end-page: 333
  ident: BIB3
  article-title: PAS domain S-boxes in Archae, Bacteria and sensors for oxygen and redox
  publication-title: Trends Biochem Sci
  contributor:
    fullname: Dixon
– volume: 11
  start-page: 72
  year: 1997
  end-page: 82
  ident: BIB14
  article-title: Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
  publication-title: Genes Dev
  contributor:
    fullname: Russell
– volume: 310
  start-page: 218
  year: 1994
  ident: 10.1016/S0959-437X(99)00003-9_BIB53
  article-title: Photoaffinity labeling of the Ah receptor: phylogenetic survey of diverse vertebrate and invertebrate species
  publication-title: Arch Biochem Biophys
  doi: 10.1006/abbi.1994.1160
  contributor:
    fullname: Hahn
– volume: 95
  start-page: 115
  year: 1954
  ident: 10.1016/S0959-437X(99)00003-9_BIB31
  article-title: Growth and regeneration in the tracheal system of an insect, Rhodnius prolixus (Hemiptera)
  publication-title: Q J Microsc Sci
  contributor:
    fullname: Wigglesworth
– volume: 172
  start-page: 249
  year: 1996
  ident: 10.1016/S0959-437X(99)00003-9_BIB39
  article-title: The Drosophila melanogaster similar bHLH-PAS gene encodes a protein related to human Hypoxia-inducible factor 1α and Drosophila Single-minded
  publication-title: Gene
  doi: 10.1016/0378-1119(96)00060-1
  contributor:
    fullname: Nambu
– volume: 248
  start-page: 789
  year: 1998
  ident: 10.1016/S0959-437X(99)00003-9_BIB18
  article-title: Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1α, HLF, and Clock
  publication-title: Biochem Biophys Res Commun
  doi: 10.1006/bbrc.1998.9012
  contributor:
    fullname: Takahata
– volume: 125
  start-page: 1599
  year: 1998
  ident: 10.1016/S0959-437X(99)00003-9_BIB36
  article-title: Regulation of Drosophila bHLH PAS protein cellular localization during embryogenesis
  publication-title: Development
  doi: 10.1242/dev.125.9.1599
  contributor:
    fullname: Ward
– volume: 9
  start-page: 416
  year: 1999
  ident: 10.1016/S0959-437X(99)00003-9_BIB9
  article-title: Biological sensors: more than one way to sense oxygen
  publication-title: Curr Biol
  doi: 10.1016/S0960-9822(99)80257-7
  contributor:
    fullname: Pellequer
– volume: 125
  start-page: 3989
  year: 1998
  ident: 10.1016/S0959-437X(99)00003-9_BIB48
  article-title: The Drosophila SOX-domain protein Dichaete is required for the development of the central nervous system midline
  publication-title: Development
  doi: 10.1242/dev.125.20.3989
  contributor:
    fullname: Sanchez-Soriano
– volume: 272
  start-page: 8581
  year: 1997
  ident: 10.1016/S0959-437X(99)00003-9_BIB17
  article-title: Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
  publication-title: J Biol Chem
  doi: 10.1074/jbc.272.13.8581
  contributor:
    fullname: Hogenesch
– volume: 11
  start-page: 72
  year: 1997
  ident: 10.1016/S0959-437X(99)00003-9_BIB14
  article-title: Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
  publication-title: Genes Dev
  doi: 10.1101/gad.11.1.72
  contributor:
    fullname: Tian
– volume: 58
  start-page: 65
  year: 1996
  ident: 10.1016/S0959-437X(99)00003-9_BIB51
  article-title: Alternate function of the single-minded and rhomboid genes in development of the Drosophila ventral neuroectoderm
  publication-title: Mech Dev
  doi: 10.1016/S0925-4773(96)00559-X
  contributor:
    fullname: Xiao
– volume: 171
  start-page: 306
  year: 1995
  ident: 10.1016/S0959-437X(99)00003-9_BIB50
  article-title: Dorsal-ventral patterning genes restrict NK-2 homeobox gene expression to the ventral half of the central nervous system of Drosophila embryos
  publication-title: Dev Biol
  doi: 10.1006/dbio.1995.1283
  contributor:
    fullname: Mellerick
– volume: 386
  start-page: 403
  year: 1997
  ident: 10.1016/S0959-437X(99)00003-9_BIB23
  article-title: Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
  publication-title: Nature
  doi: 10.1038/386403a0
  contributor:
    fullname: Maltepe
– volume: 95
  start-page: 5884
  year: 1998
  ident: 10.1016/S0959-437X(99)00003-9_BIB10
  article-title: Photoactive yellow protein: a structural prototype for the three-dimensional fold of the PAS domain superfamily
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.95.11.5884
  contributor:
    fullname: Pellequer
– volume: 92
  start-page: 5510
  year: 1995
  ident: 10.1016/S0959-437X(99)00003-9_BIB13
  article-title: Hypoxia-inducible factor 1 is a basic helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.92.12.5510
  contributor:
    fullname: Wang
– volume: 249
  start-page: 811
  year: 1998
  ident: 10.1016/S0959-437X(99)00003-9_BIB40
  article-title: Regulation of the Drosophila bHLH-PAS protein Sima by hypoxia: functional evidence for homology with mammalian HIF-1α
  publication-title: Biochem Biophys Res Comm
  doi: 10.1006/bbrc.1998.9234
  contributor:
    fullname: Bacon
– volume: 12
  start-page: 1290
  year: 1998
  ident: 10.1016/S0959-437X(99)00003-9_BIB54
  article-title: Control of distal antennal identity and tarsal development in Drosophila by spineless-aristapedia, a homolog of the mammalian dioxin receptor
  publication-title: Genes Dev
  doi: 10.1101/gad.12.9.1290
  contributor:
    fullname: Duncan
– volume: 398
  start-page: 622
  year: 1999
  ident: 10.1016/S0959-437X(99)00003-9_BIB49
  article-title: Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
  publication-title: Nature
  doi: 10.1038/19315
  contributor:
    fullname: Briscoe
– volume: 7
  start-page: 569
  year: 1997
  ident: 10.1016/S0959-437X(99)00003-9_BIB41
  article-title: Single-minded — two genes, three chromosomes
  publication-title: Genome Research
  doi: 10.1101/gr.7.6.569
  contributor:
    fullname: Michaud
– volume: 95
  start-page: 2844
  year: 1998
  ident: 10.1016/S0959-437X(99)00003-9_BIB55
  article-title: Caenorhabditis elegans orthologs of the aryl hydrocarbon receptor and its heterodimerization partner the aryl hydrocarbon receptor nuclear translocator
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.95.6.2844
  contributor:
    fullname: Powell-Coffman
– volume: 93
  start-page: 6731
  year: 1996
  ident: 10.1016/S0959-437X(99)00003-9_BIB58
  article-title: Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.93.13.6731
  contributor:
    fullname: Schmidt
– volume: 89
  start-page: 9
  year: 1997
  ident: 10.1016/S0959-437X(99)00003-9_BIB12
  article-title: The hypoxic response: huffing and HIFing
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80176-2
  contributor:
    fullname: Guillemin
– volume: 120
  start-page: 3563
  year: 1994
  ident: 10.1016/S0959-437X(99)00003-9_BIB47
  article-title: Control of CNS midline transcription by asymmetric E-box elements: similarity to xenobiotic responsive regulation
  publication-title: Development
  doi: 10.1242/dev.120.12.3563
  contributor:
    fullname: Wharton
– volume: 95
  start-page: 649
  year: 1998
  ident: 10.1016/S0959-437X(99)00003-9_BIB8
  article-title: Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81635-9
  contributor:
    fullname: Cabral
– volume: 191
  start-page: 297
  year: 1997
  ident: 10.1016/S0959-437X(99)00003-9_BIB24
  article-title: ARNT-deficient mice and placental differentiation
  publication-title: Dev Biol
  doi: 10.1006/dbio.1997.8758
  contributor:
    fullname: Kozak
– volume: 27
  start-page: 109
  year: 1997
  ident: 10.1016/S0959-437X(99)00003-9_BIB52
  article-title: Aryl hydrocarbon receptor-mediated signal transduction
  publication-title: Crit Rev Toxicol
  doi: 10.3109/10408449709021615
  contributor:
    fullname: Rowlands
– volume: 95
  start-page: 15177
  year: 1998
  ident: 10.1016/S0959-437X(99)00003-9_BIB7
  article-title: Structure of a biological oxygen sensor: a new mechanism for heme-driven signal transduction
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.95.26.15177
  contributor:
    fullname: Gong
– volume: 209
  start-page: 254
  year: 1999
  ident: 10.1016/S0959-437X(99)00003-9_BIB25
  article-title: Defective vascularization of HIF-1α-null embryos is not associated with VEGF deficiency but with mesenchymal cell death
  publication-title: Dev Biol
  doi: 10.1006/dbio.1999.9253
  contributor:
    fullname: Kotch
– volume: 17
  start-page: 3005
  year: 1998
  ident: 10.1016/S0959-437X(99)00003-9_BIB21
  article-title: HIF-1α is required for solid tumor formation and embryonic vascularization
  publication-title: EMBO J
  doi: 10.1093/emboj/17.11.3005
  contributor:
    fullname: Ryan
– volume: 29
  start-page: 1127
  year: 1995
  ident: 10.1016/S0959-437X(99)00003-9_BIB2
  article-title: Atypical phytochrome gene structure in the green alga Mesotaenium caldariorum
  publication-title: Plant Mol Biol
  doi: 10.1007/BF00020457
  contributor:
    fullname: Lagarias
– volume: 22
  start-page: 331
  year: 1997
  ident: 10.1016/S0959-437X(99)00003-9_BIB3
  article-title: PAS domain S-boxes in Archae, Bacteria and sensors for oxygen and redox
  publication-title: Trends Biochem Sci
  doi: 10.1016/S0968-0004(97)01110-9
  contributor:
    fullname: Zhulin
– volume: 394
  start-page: 485
  year: 1998
  ident: 10.1016/S0959-437X(99)00003-9_BIB22
  article-title: Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
  publication-title: Nature
  doi: 10.1038/28867
  contributor:
    fullname: Carmeliet
– volume: 12
  start-page: 607
  year: 1998
  ident: 10.1016/S0959-437X(99)00003-9_BIB1
  article-title: Control of cell lineage-specific development and transcription by bHLH-PAS proteins
  publication-title: Genes Dev
  doi: 10.1101/gad.12.5.607
  contributor:
    fullname: Crews
– volume: 96
  start-page: 57
  year: 1999
  ident: 10.1016/S0959-437X(99)00003-9_BIB46
  article-title: A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80959-9
  contributor:
    fullname: Jin
– volume: 124
  start-page: 4583
  year: 1997
  ident: 10.1016/S0959-437X(99)00003-9_BIB35
  article-title: The Drosophila tango gene encodes a bHLH-PAS protein that is orthologous to mammalian Arnt and controls CNS midline and tracheal development
  publication-title: Development
  doi: 10.1242/dev.124.22.4571
  contributor:
    fullname: Sonnenfeld
– volume: 9
  start-page: 123
  year: 1995
  ident: 10.1016/S0959-437X(99)00003-9_BIB45
  article-title: drifter, a Drosophila POU-domain transcription factor, is required for correct differentiation and migration of tracheal cells and midline glia
  publication-title: Genes Dev
  doi: 10.1101/gad.9.1.123
  contributor:
    fullname: Anderson
– volume: 34
  start-page: 6278
  year: 1995
  ident: 10.1016/S0959-437X(99)00003-9_BIB6
  article-title: 1.4 Å structure of photoactive yellow protein, a cytosolic photoreceptor: unusual fold, active site, and chromophore
  publication-title: Biochemistry
  doi: 10.1021/bi00019a004
  contributor:
    fullname: Borgstahl
– volume: 380
  start-page: 439
  year: 1996
  ident: 10.1016/S0959-437X(99)00003-9_BIB28
  article-title: Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
  publication-title: Nature
  doi: 10.1038/380439a0
  contributor:
    fullname: Ferrara
– volume: 10
  start-page: 93
  year: 1996
  ident: 10.1016/S0959-437X(99)00003-9_BIB33
  article-title: trachealess encodes a bHLH-PAS protein and is a master regulator gene in the Drosophila tracheal system
  publication-title: Genes Dev
  doi: 10.1101/gad.10.1.93
  contributor:
    fullname: Wilk
– volume: 124
  start-page: 3975
  year: 1997
  ident: 10.1016/S0959-437X(99)00003-9_BIB37
  article-title: Transcriptional regulation of breathless FGF receptor gene by binding of TRACHEALESS/dARNT heterodimers to three central midline elements in Drosophila developing trachea
  publication-title: Development
  doi: 10.1242/dev.124.20.3975
  contributor:
    fullname: Ohshiro
– volume: 51
  start-page: 223
  year: 1998
  ident: 10.1016/S0959-437X(99)00003-9_BIB26
  article-title: Physical localization of the mouse aryl hydrocarbon receptor nuclear translocator-2 (Arnt2) gene with the c112K deletion
  publication-title: Genomics
  doi: 10.1006/geno.1998.5347
  contributor:
    fullname: Wines
– volume: 15
  start-page: 591
  year: 1994
  ident: 10.1016/S0959-437X(99)00003-9_BIB44
  article-title: Localization of Locusta-DP in locust CNS and hemolymph satisfies initial hormonal criteria
  publication-title: Peptides
  doi: 10.1016/0196-9781(94)90081-7
  contributor:
    fullname: Patel
– volume: 26
  start-page: 3937
  year: 1999
  ident: 10.1016/S0959-437X(99)00003-9_BIB56
  article-title: The Drosophila Spineless-Aristapedia and Tango bHLH-PAS proteins interact to control antennal and tarsal development
  publication-title: Development
  doi: 10.1242/dev.126.17.3937
  contributor:
    fullname: Emmons
– volume: 12
  start-page: 149
  year: 1998
  ident: 10.1016/S0959-437X(99)00003-9_BIB20
  article-title: Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α
  publication-title: Genes Dev
  doi: 10.1101/gad.12.2.149
  contributor:
    fullname: Iyer
– volume: 7
  start-page: 1
  year: 1996
  ident: 10.1016/S0959-437X(99)00003-9_BIB42
  article-title: Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome
  publication-title: Mol Cell Neuro
  doi: 10.1006/mcne.1996.0001
  contributor:
    fullname: Fan
– volume: 7
  start-page: 674
  year: 1997
  ident: 10.1016/S0959-437X(99)00003-9_BIB4
  article-title: PAS: a multifunctional domain family comes to light
  publication-title: Curr Biol
  doi: 10.1016/S0960-9822(06)00352-6
  contributor:
    fullname: Ponting
– volume: 8
  start-page: 588
  year: 1998
  ident: 10.1016/S0959-437X(99)00003-9_BIB11
  article-title: Hypoxia-inducible factor 1: master regulator of O2 homeostasis
  publication-title: Curr Opin Genet Dev
  doi: 10.1016/S0959-437X(98)80016-6
  contributor:
    fullname: Semenza
– volume: 387
  start-page: 161
  year: 1996
  ident: 10.1016/S0959-437X(99)00003-9_BIB38
  article-title: Drosophila melanogaster SL2 cells contain a hypoxically inducible DNA binding complex which recognises mammalian HIF-1 binding sites
  publication-title: FEBS Lett
  doi: 10.1016/0014-5793(96)00484-X
  contributor:
    fullname: Nagao
– volume: 94
  start-page: 713
  year: 1997
  ident: 10.1016/S0959-437X(99)00003-9_BIB16
  article-title: Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.94.2.713
  contributor:
    fullname: Zhou
– volume: 46
  start-page: 325
  year: 1997
  ident: 10.1016/S0959-437X(99)00003-9_BIB32
  article-title: Anoxia regulates gene expression in the central nervous system of Drosophila melanogaster
  publication-title: Mol Brain Res
  doi: 10.1016/S0169-328X(97)00074-0
  contributor:
    fullname: Ma
– volume: 7
  start-page: 205
  year: 1998
  ident: 10.1016/S0959-437X(99)00003-9_BIB15
  article-title: Molecular characterization and chromosomal localization of a third a-class hypoxia inducible factor subunit, HIF3α
  publication-title: Gene Expression
  contributor:
    fullname: Gu
– volume: 95
  start-page: 5474
  year: 1998
  ident: 10.1016/S0959-437X(99)00003-9_BIB19
  article-title: The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.95.10.5474
  contributor:
    fullname: Hogenesch
– volume: 268
  start-page: 722
  year: 1995
  ident: 10.1016/S0959-437X(99)00003-9_BIB57
  article-title: Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor
  publication-title: Science
  doi: 10.1126/science.7732381
  contributor:
    fullname: Fernandez-Salguero
– volume: 10
  start-page: 103
  year: 1996
  ident: 10.1016/S0959-437X(99)00003-9_BIB34
  article-title: Tubulogenesis in Drosophila: a requirement for the trachealess gene product
  publication-title: Genes Dev
  doi: 10.1101/gad.10.1.103
  contributor:
    fullname: Isaac
– volume: 12
  start-page: 3320
  year: 1998
  ident: 10.1016/S0959-437X(99)00003-9_BIB29
  article-title: The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
  publication-title: Genes Dev
  doi: 10.1101/gad.12.21.3320
  contributor:
    fullname: Tian
– volume: 43
  start-page: 203
  year: 1997
  ident: 10.1016/S0959-437X(99)00003-9_BIB30
  article-title: Behavioral and electrophysiologic responses of Drosophila melanogaster to prolonged periods of anoxia
  publication-title: J Insect Physiol
  doi: 10.1016/S0022-1910(96)00084-4
  contributor:
    fullname: Krishnan
– volume: 12
  start-page: 3264
  year: 1998
  ident: 10.1016/S0959-437X(99)00003-9_BIB43
  article-title: Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1
  publication-title: Genes Dev
  doi: 10.1101/gad.12.20.3264
  contributor:
    fullname: Michaud
– volume: 96
  start-page: 271
  year: 1999
  ident: 10.1016/S0959-437X(99)00003-9_BIB5
  article-title: Molecular bases for circadian clocks
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80566-8
  contributor:
    fullname: Dunlap
– volume: 380
  start-page: 435
  year: 1996
  ident: 10.1016/S0959-437X(99)00003-9_BIB27
  article-title: Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
  publication-title: Nature
  doi: 10.1038/380435a0
  contributor:
    fullname: Carmeliet
SSID ssj0002116
Score 2.0723884
SecondaryResourceType review_article
Snippet Strange fits of passion I have known… (W Wordsworth, ‘Strange fits of passion’.) bHLH–PAS proteins are regulators of developmental and physiological events...
Strange fits of passion I have knownellipsis (W Wordsworth, 'Strange fits of passion'.) bHLH-PAS proteins are regulators of developmental and physiological...
bHLH-PAS proteins are regulators of developmental and physiological events that are well conserved between vertebrates and invertebrates. Recent studies using...
SourceID proquest
crossref
pubmed
elsevier
SourceType Aggregation Database
Index Database
Publisher
StartPage 580
SubjectTerms Animals
Aryl hydrocarbon receptors
Cell Lineage
Drosophila
Drosophila - cytology
Drosophila - genetics
Helix-Loop-Helix Motifs
Homeostasis
Hypoxia
Mice
Oxygen - metabolism
PAS domain proteins
Protein Conformation
spineless gene
Transcription Factors - chemistry
Transcription Factors - physiology
Title Remembrance of things PAS: regulation of development by bHLH–PAS proteins
URI https://dx.doi.org/10.1016/S0959-437X(99)00003-9
https://www.ncbi.nlm.nih.gov/pubmed/10508688
https://search.proquest.com/docview/17437918
https://search.proquest.com/docview/70791280
Volume 9
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV07T8MwED6VIiSYeFOeHhhgCI2xG8dsqAIFChXiIXWz4sSVOjSt2nRgQfwH_iG_hLOTUhgqJFYntqzvnPN3zvk-gGPGEx2k0uq7pIGTMPNCmtiDfG0E5d3Yj22geN8Oohd-22l0KtCc3oWxaZWl7y98uvPWZUu9RLM-7PXqT_YEizPRkVb30mdyARZxO-K8CouXN62o_e2QMcYJipJ70rMdZhd5ikFc44mUp24cT87bouZRULcVXa_Cir2eQIoz_TWomGwdlgpFydcNaD2avulrq5ZhyKBLcifLSR4uny7IqJCdR0PYJ-ksW4joV6Kju-jz_QNfJK50Qy8bb8LL9dVzM_JKvQQvwS8rt1n8VIR-lwuMehrGRncs0dIghUNSl1KmkzjlSDjCUCKRCRjT8tyPtW-QuyYJZ1tQzQaZ2QEiYxHEpkFDbdBgjGsqNEc2gPFMKoSf1uBsCpEaFmUx1CxfDDFVFlMlpXKYKlmDcAqk-mVfha77r65HU-AVrn37QyPOzGAyVjaaEpKG89-w9f9wB_ZrsF1Y7MdskZoiErv_n9geLLsiDi61bx-q-WhiDpCi5PoQFs7e6GG5EL8AW9Xd9w
link.rule.ids 314,315,786,790,798,4521,24144,27955,27957,27958,45620,45714
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV07T8MwED7xEAIm3pRXPTDAkDbBbhyzIQQK9CEEVOpmxYkrdWiKaDuwIP4D_5Bfwp3TqjBUSKyOY1nfOefvnPN9AKdcpCbMFOm7ZKGTMPOiIKWDfGNlILqJn1Cg2GyFcVvcd2qdBbie3oWhtMqJ7y98uvPWk5bqBM3qS69XfaITLMFlR5Hupc_VIiwTnSf9hsr7LM8DI5ywKLinPOo-u8ZTDOEaz5Q6d6N4at4GNY-Auo3odgPW6XICK070N2HB5luwUuhJvm1D_dH2bd-QVoZlgy4bOVFO9nD1dMleC9F5NAM9yWa5Qsy8MRM34q-PT-zIXOGGXj7cgfbtzfN17E3UErwUv6sR5fAHMvK7QmLMU7MU2_HUKIsEDildFnCTJplAuhFFCmlMyLlRF35ifIvMNU0F34WlfJDbfWAqkWFia0FkLJqLCxNII5ALYDSTSelnJahMIdIvRVEMPcsWQ0w1YaqV0g5TrUoQTYHUv6yr0XH_9Wp5CrzGlU-_M5LcDsZDTbGUVEE0vwdV_8P91y_BXmGxH7NFYopIHPx_YmVYjZ-bDd24a9UPYc2Vc3BJfkewNHod22MkKyNz4hbjNzPf3sU
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Remembrance+of+things+PAS%3A+regulation+of+development+by+bHLH%E2%80%93PAS+proteins&rft.jtitle=Current+Opinion+in+Genetics+%26+Development&rft.au=Crews%2C+Stephen+T&rft.au=Fan%2C+Chen-Ming&rft.date=1999-10-01&rft.pub=Elsevier+Ltd&rft.issn=0959-437X&rft.eissn=1879-0380&rft.volume=9&rft.issue=5&rft.spage=580&rft.epage=587&rft_id=info:doi/10.1016%2FS0959-437X%2899%2900003-9&rft.externalDocID=S0959437X99000039
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0959-437X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0959-437X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0959-437X&client=summon