Intronic Polymorphisms Affecting Alternative Splicing of Human Dopamine D2 Receptor Are Associated with Cocaine Abuse

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 36; no. 4; pp. 753 - 762
• Main Authors: Moyer, Robert A, Wang, Danxin, Papp, Audrey C, Smith, Ryan M, Duque, Linda, Mash, Deborah C, Sadee, Wolfgang
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.03.2011; Nature Publishing Group
• Subjects: 631/208/2489/144; 631/208/726/649; 631/337/1645/1946; 692/699/476/5; Addictive behaviors; Adult; Adult and adolescent clinical studies; Alternative splicing; Alternative Splicing - genetics; Autopsy; Behavioral Sciences; Biological and medical sciences; Biological Psychology; Brain; Brain - metabolism; Brain - pathology; Cocaine; Cocaine-Related Disorders - genetics; Cocaine-Related Disorders - metabolism; Cocaine-Related Disorders - pathology; Cortex (prefrontal); Dopamine D2 receptors; Drug abuse; Drug addiction; Exons; Female; Genetic Predisposition to Disease; HEK293 Cells; Humans; Introns; Introns - genetics; Linkage disequilibrium; Male; Medical sciences; Medicine; Medicine & Public Health; Memory; Mental disorders; Middle Aged; mRNA; Neuropharmacology; Neurosciences; Original; original-article; Pharmacology. Drug treatments; Pharmacotherapy; Polymorphism, Single Nucleotide - genetics; Psychiatry; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; Putamen; Receptors, Dopamine D2 - biosynthesis; Receptors, Dopamine D2 - genetics; Single-nucleotide polymorphism; Young Adult; alternative splicing; D2S; DRD2; cocaine; dopamine; human; Human; Alternative splicing; Drug addiction; Dopamine; CNS stimulant; Psychotropic; Catecholamine; Ester; D2 Dopamine receptor; Neurotransmitter; Cocaine; Drug of abuse; Polymorphism

The dopamine receptor D2 (encoded by DRD2 ) is implicated in susceptibility to mental disorders and cocaine abuse, but mechanisms responsible for this relationship remain uncertain. DRD2 mRNA exists in two main splice isoforms with distinct functions: D2 long (D2L) and D2 short (D2S, lacking exon 6)...