Elimination Kinetics of the Tobacco-Specific Biomarker and Lung Carcinogen 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol

• Published in: Cancer epidemiology, biomarkers & prevention Vol. 18; no. 12; pp. 3421 - 3425
• Main Authors: Goniewicz, Maciej L., Havel, Christopher M., Peng, Margaret Wilson, Jacob, Peyton, Dempsey, Delia, Yu, Lisa, Zielinska-Danch, Wioleta, Koszowski, Bartosz, Czogala, Jan, Sobczak, Andrzej, Benowitz, Neal L.
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research 01.12.2009
• Subjects: Adult; Biomarkers, Pharmacological - urine; Carcinogens - pharmacokinetics; Chromatography, Liquid; elimination; Female; Half-Life; Humans; Lung - drug effects; Male; Middle Aged; Nitrosamines - pharmacokinetics; NNAL; Risk Factors; Smoking; Tandem Mass Spectrometry; Tissue Distribution; tobacco biomarker; urine half-life

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is tobacco specific and has a longer half-life than other tobacco biomarkers studied thus far. An accurate measurement of the NNAL half-life is important for optimal use to assess exposure to tobacco smoke. We determined the half-life of NNAL in u...