Minor Antigen Distribution Predicts Site-Specific Graft-versus-Tumor Activity of Adoptively Transferred, Minor Antigen-Specific CD8 T Cells

• Published in: Biology of blood and marrow transplantation Vol. 20; no. 1; pp. 26 - 36
• Main Authors: Shand, Jessica C, Qin, Haiying, Nasholm, Nicole, Capitini, Christian M, Fry, Terry J
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2014
• Subjects: Acute lymphoblastic leukemia; Adoptive T cell therapy; Adoptive Transfer; Alleles; Allogeneic transplantation; Animals; Bone Marrow Transplantation; CD8-Positive T-Lymphocytes - cytology; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - transplantation; CD8 T cell function; Cell Proliferation; Dendritic Cells - immunology; Dendritic Cells - pathology; Female; Gene Expression - immunology; Graft vs Host Disease - genetics; Graft vs Host Disease - immunology; Graft vs Host Disease - mortality; Graft vs Host Disease - pathology; Graft vs Leukemia Effect; H-Y Antigen - genetics; H-Y Antigen - immunology; Hematology, Oncology and Palliative Medicine; Humans; Immunophenotyping; Lymphocyte Depletion; Male; Mice; Mice, Transgenic; Minor histocompatibility antigens; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - immunology; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy; Precursor Cells, B-Lymphoid - immunology; Precursor Cells, B-Lymphoid - pathology; Survival Analysis; CD8 T cell function; Acute lymphoblastic leukemia; Allogeneic transplantation; Minor histocompatibility antigens; Adoptive T cell therapy

Abstract The clinical success of allogeneic T cell therapy for cancer relies on the selection of antigens that can effectively elicit antitumor responses with minimal toxicity toward nonmalignant tissues. Although minor histocompatibility antigens (MiHA) represent promising targets, broad expression...