Differentially expressed microRNAs in exosomes of patients with breast cancer revealed by next‑generation sequencing

• Published in: Oncology reports Vol. 43; no. 1; pp. 240 - 250
• Main Authors: Wu, Heming, Wang, Qiuming, Zhong, Hua, Li, Liang, Zhang, Qunji, Huang, Qingyan, Yu, Zhikang
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.01.2020; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Analysis; Biological markers; Biomarkers; Biotechnology industries; Breast cancer; Cancer metastasis; Cancer patients; Chemotherapy; Deoxyribonucleic acid; Development and progression; DNA; EDTA; Epidermal growth factors; Gene expression; Genomes; Genomic libraries; Growth factors; Kinases; Messenger RNA; Metastasis; MicroRNA; MicroRNAs; Mortality; Polymerase chain reaction; Public relations executives; Recurrence (Disease); RNA; RNA sequencing; Somatotropin; United States; Taiwan; China

MicroRNAs (miRNAs/miRs) in exosomes play crucial roles in the onset, progression and metastasis of cancer by regulating the stability of target mRNAs or by inhibiting translation. In the present study, differentially expressed miRNAs were identified in exosomes of 27 breast cancer patients and 3 hea...