Efficient and safe internalization of magnetic iron oxide nanoparticles: Two fundamental requirements for biomedical applications

• Published in: Nanomedicine Vol. 10; no. 4; pp. 733 - 743
• Main Authors: Calero, Macarena, MS, Gutiérrez, Lucía, PhD, Salas, Gorka, PhD, Luengo, Yurena, MS, Lázaro, Ana, MS, Acedo, Pilar, MS, Morales, M. Puerto, PhD, Miranda, Rodolfo, PhD, Villanueva, Angeles, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2014
• Subjects: Cellular uptake; Cytoskeleton; Cytoskeleton - metabolism; Cytoskeleton - ultrastructure; Cytoxicity; Ferric Compounds - chemistry; Ferric Compounds - pharmacology; HeLa cell line; HeLa Cells; Humans; Internal Medicine; Iron oxide magnetic nanoparticles; Magnetite Nanoparticles - chemistry; Magnetite Nanoparticles - ultrastructure; Reactive Oxygen Species - metabolism; HeLa cell line; Cytoskeleton; Cellular uptake; Cytoxicity; Iron oxide magnetic nanoparticles

Abstract We have performed a series of in vitro tests proposed for the reliable assessment of safety associated with nanoparticles-cell interaction. A thorough analysis of toxicity of three different coating iron oxide nanoparticles on HeLa cells has been carried out including, methyl thiazol tetraz...