New translational assays for preclinical modelling of cognition in schizophrenia: The touchscreen testing method for mice and rats

• Published in: Neuropharmacology Vol. 62; no. 3; pp. 1191 - 1203
• Main Authors: Bussey, T.J., Holmes, A., Lyon, L., Mar, A.C., McAllister, K.A.L., Nithianantharajah, J., Oomen, C.A., Saksida, L.M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2012
• Subjects: Animals; Attention; Autoshaping; Cognition; Cognition Disorders - physiopathology; Cognition Disorders - psychology; Computers; Discrimination, Psychological; Disease Models, Animal; Extinction; Mice; Neurogenesis; Neuropsychological Tests; Paired associate learning; Pattern separation; PCP; Photic Stimulation; Psychomotor Performance; Rats; Schizophrenia - physiopathology; Schizophrenic Psychology; Touch; Translational Research, Biomedical - methods; Visual discrimination; Working memory; Extinction; Pattern separation; Attention; Paired associate learning; Autoshaping; Cognition; Working memory; PCP; Visual discrimination; Neurogenesis

We describe a touchscreen method that satisfies a proposed ‘wish-list’ of desirables for a cognitive testing method for assessing rodent models of schizophrenia. A number of tests relevant to schizophrenia research are described which are currently being developed and validated using this method. Th...