The Binding Effect of Proteins on Medications and Its Impact on Electrochemical Sensing: Antipsychotic Clozapine as a Case Study

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 10; no. 3; p. 69
• Main Authors: Banis, George E, Winkler, Thomas, Barton, Patricia, Chocron, Sheryl E, Kim, Eunkyoung, Kelly, Deanna L, Payne, Gregory F, Ben-Yoav, Hadar, Ghodssi, Reza
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.08.2017; MDPI
• Subjects: albumin; alpha-1 acid-glycoprotein; clozapine; electrochemistry; Proteins; Psychotropic drugs; ultrafiltration; clozapine; alpha-1 acid-glycoprotein; electrochemistry; ultrafiltration; albumin

Clozapine (CLZ), a dibenzodiazepine, is demonstrated as the optimal antipsychotic for patients suffering from treatment-resistant schizophrenia. Like many other drugs, understanding the concentration of CLZ in a patient's blood is critical for managing the patients' symptoms, side effects,...