Valproic acid induces up- or down-regulation of gene expression responsible for the neuronal excitation and inhibition in rat cortical neurons through its epigenetic actions

• Published in: Neuroscience research Vol. 65; no. 1; pp. 35 - 43
• Main Authors: Fukuchi, Mamoru, Nii, Takuya, Ishimaru, Naoki, Minamino, Aya, Hara, Daichi, Takasaki, Ichiro, Tabuchi, Akiko, Tsuda, Masaaki
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.09.2009
• Subjects: Animals; BDNF; Blotting, Western; Brain-Derived Neurotrophic Factor - metabolism; Calcium Signaling; Cells, Cultured; Cerebral Cortex - cytology; Cerebral Cortex - drug effects; Cerebral Cortex - metabolism; Chromatin Immunoprecipitation; Down-Regulation; Epigenesis, Genetic; GABA A receptor; GAD; Gene Expression Profiling; Glutamate Decarboxylase - metabolism; HDAC inhibitor; Histone acetylation; Histones - metabolism; K Cl- Cotransporters; Neurons - drug effects; Neurons - metabolism; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Receptors, GABA-A - metabolism; Symporters - metabolism; Up-Regulation; Valproic Acid - pharmacology; VPA; HDAC inhibitor; Histone acetylation; GAD; GABA A receptor; BDNF; VPA

Valproic acid (VPA), a drug used to treat epilepsy and bipolar mood disorder, inhibits histone deacetylase (HDAC), which is associated with the epigenetic regulation of gene expression. Using a microarray, we comprehensively examined which genes are affected by stimulating cultured rat cortical neur...