Valproic acid induces up- or down-regulation of gene expression responsible for the neuronal excitation and inhibition in rat cortical neurons through its epigenetic actions - Fukuchi, Mamoru; Nii, Takuya; Ishimaru, Naoki; Minamino, Aya; Hara, Daichi; Takasaki, Ichiro; Tabuchi, Akiko; Tsuda, Masaaki (Neuroscience research, 2009)
Keywords: Animals; BDNF; Blotting, Western; Brain-Derived Neurotrophic Factor - metabolism; Calcium Signaling; Cells, Cultured; Cerebral Cortex - cytology; Cerebral Cortex - drug effects; Cerebral Cortex - metabolism; Chromatin Immunoprecipitation; Down-Regulation; Epigenesis, Genetic; GABA A receptor; GAD; Gene Expression Profiling; Glutamate Decarboxylase - metabolism; HDAC inhibitor; Histone acetylation; Histones - metabolism; K Cl- Cotransporters; Neurons - drug effects; Neurons - metabolism; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Receptors, GABA-A - metabolism; Symporters - metabolism; Up-Regulation; Valproic Acid - pharmacology; VPA; HDAC inhibitor; Histone acetylation; GAD; GABA A receptor; BDNF; VPA