Genome-Wide Analysis Uncovers Novel Recurrent Alterations in Primary Central Nervous System Lymphomas

• Published in: Clinical cancer research Vol. 21; no. 17; pp. 3986 - 3994
• Main Authors: Braggio, Esteban, Van Wier, Scott, Ojha, Juhi, McPhail, Ellen, Asmann, Yan W., Egan, Jan, da Silva, Jackline Ayres, Schiff, David, Lopes, M. Beatriz, Decker, Paul A., Valdez, Riccardo, Tibes, Raoul, Eckloff, Bruce, Witzig, Thomas E., Stewart, A. Keith, Fonseca, Rafael, O'Neill, Brian Patrick
• Format: Journal Article
• Language: English
• Published: United States 01.09.2015
• Subjects: Central Nervous System Neoplasms - genetics; Central Nervous System Neoplasms - metabolism; Central Nervous System Neoplasms - mortality; Chromosome Aberrations; Chromosomes, Human, Pair 6; Comparative Genomic Hybridization; DNA Copy Number Variations; Exome; Genetic Variation; Genome-Wide Association Study; High-Throughput Nucleotide Sequencing; Humans; Karyotype; Lymphoma, Non-Hodgkin - genetics; Lymphoma, Non-Hodgkin - metabolism; Lymphoma, Non-Hodgkin - mortality; Mutation; Prognosis

Purpose: Primary central nervous system lymphoma (PCNSL) is an aggressive non-Hodgkin lymphoma confined to the central nervous system. Whether there is a PCNSL-specific genomic signature and, if so, how it differs from systemic diffuse large B-cell lymphoma (DLBCL) is uncertain. Experimental Design:...