Immunohistochemical analysis of expressions of hepatic cytochrome P450 in F344 rats following oral treatment with kava extract

• Published in: Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie Vol. 58; no. 4; pp. 223 - 236
• Main Authors: Clayton, Natasha P., Yoshizawa, Katsuhiko, Kissling, Grace E., Burka, Leo T., Chan, Po-Chuen, Nyska, Abraham
• Format: Journal Article
• Language: English
• Published: Jena Elsevier GmbH 01.01.2007; Elsevier
• Subjects: Administration, Oral; Animals; Biological and medical sciences; Blood Glucose - drug effects; Cholesterol - blood; Cytochrome P-450 Enzyme System - drug effects; Cytochrome P-450 Enzyme System - metabolism; Cytochrome P450; Dietary Supplements - toxicity; Dose-Response Relationship, Drug; F344 rat; Female; gamma-Glutamyltransferase - blood; gamma-Glutamyltransferase - drug effects; Hepatocellular hypertrophy; Herb; Hypertrophy - chemically induced; Immunohistochemistry; Investigative techniques, diagnostic techniques (general aspects); Kava; Kava - toxicity; Liver - drug effects; Liver - enzymology; Liver - pathology; Liver Function Tests; Male; Medical sciences; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Piper methysticum; Rats; Rats, Inbred F344; Kava; Piper methysticum; F344 rat; Cytochrome P450; Hepatocellular hypertrophy; Herb; Immunohistochemistry; Rat; Digestive system; Liver; Rodentia; Oral administration; Piperaceae; Extract; Vertebrata; Anatomic pathology; Mammalia; Dicotyledones; Animal; Angiospermae; Spermatophyta; Hypertrophy

Kava ( Piper methysticum), used for relaxation and pain relief, has been one of the leading dietary supplements and several reports linking hepatic functional disturbances and liver failure to kava have resulted in a ban on sales in Europe and Canada and the issuance of warnings by the US FDA. The N...