Differential limbic–cortical correlates of sadness and anxiety in healthy subjects: implications for affective disorders

• Published in: Biological psychiatry (1969) Vol. 48; no. 1; pp. 30 - 42
• Main Authors: Liotti, Mario, Mayberg, Helen S, Brannan, Stephan K, McGinnis, Scott, Jerabek, Paul, Fox, Peter T
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.2000; Elsevier Science
• Subjects: Adult; Adult and adolescent clinical studies; anxiety; Anxiety - diagnostic imaging; Biological and medical sciences; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - physiology; Cerebrovascular Circulation; Depression; Depression - diagnostic imaging; dorsal/ventral pathways; Female; Humans; Imagination; limbic system; Limbic System - diagnostic imaging; Limbic System - physiology; Magnetic Resonance Imaging; Medical sciences; Mood disorders; Mood Disorders - physiopathology; Nerve Net; positron emission tomography; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Reference Values; Sadness; Tomography, Emission-Computed; anxiety; limbic system; depression; positron emission tomography; Sadness; dorsal/ventral pathways; Radionuclide study; Mood disorder; Human; Regional blood flow; Cerebral cortex; Central nervous system; Depression; Exploration; Limbic system; Concomitant disease; Specificity; Interindividual comparison; Distribution; Anxiety; Hemodynamics; Brain (vertebrata); Positron; Emission tomography

Background: Affective disorders are associated with comorbidity of depression and anxiety symptoms. Positron emission tomography resting-state studies in affective disorders have generally failed to isolate specific symptom effects. Emotion provocation studies in healthy volunteers have produced var...