Association between the surfactant protein D ( SFTPD ) gene and subclinical carotid artery atherosclerosis

• Published in: Atherosclerosis Vol. 246; pp. 7 - 12
• Main Authors: Sorensen, Grith L, Bladbjerg, Else Marie, Steffensen, Rudi, Tan, Qihua, Madsen, Jens, Drivsholm, Thomas, Holmskov, Uffe
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.03.2016
• Subjects: Asymptomatic Diseases; Atherosclerosis; Cardiovascular; Carotid Arteries - diagnostic imaging; Carotid Artery Diseases - blood; Carotid Artery Diseases - diagnostic imaging; Carotid Artery Diseases - genetics; Carotid Intima-Media Thickness; Chi-Square Distribution; Denmark; Female; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Intima-media thickness; Linear Models; Logistic Models; Male; Middle Aged; Multivariate Analysis; Phenotype; Plaque, Atherosclerotic; Polymorphism, Single Nucleotide; Pulmonary Surfactant-Associated Protein D - blood; Pulmonary Surfactant-Associated Protein D - genetics; Risk Assessment; Risk Factors; Single nucleotide polymorphisms; Smoking - adverse effects; Surfactant protein D; Intima-media thickness; Surfactant protein D; Single nucleotide polymorphisms; Atherosclerosis

Abstract Objective Surfactant protein D (SP-D) is a defense collectin with inflammation-modulating properties. SP-D deficiency inhibits atherosclerosis in vivo , and the circulatory SP-D levels have been previously associated with cardiovascular disease mortality. We hypothesized that plasma SP-D (p...