Detection of JC Virus-Specific Cytotoxic T Lymphocytes in Healthy Individuals

Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from...

Full description

Saved in:
Bibliographic Details
Published inJournal of Virology Vol. 78; no. 18; pp. 10206 - 10210
Main Authors Du Pasquier, R. A., Schmitz, J. E., Jean-Jacques, J., Zheng, Y., Gordon, J., Khalili, K., Letvin, N. L., Koralnik, I. J.
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.09.2004
Subjects
Adult
Biological and medical sciences
Cytomegalovirus
Cytomegalovirus - immunology
DNA-Binding Proteins - immunology
Fundamental and applied biological sciences. Psychology
HLA-A Antigens - metabolism
HLA-A2 Antigen
Humans
Immunocompetence
Immunodominant Epitopes
JC virus
JC Virus - immunology
JC Virus - pathogenicity
JC Virus - physiology
Leukoencephalopathy, Progressive Multifocal - immunology
Leukoencephalopathy, Progressive Multifocal - prevention & control
Leukoencephalopathy, Progressive Multifocal - virology
Microbiology
Miscellaneous
Pathogenesis and Immunity
Plant Proteins
Polyomavirus
T-Lymphocytes, Cytotoxic - immunology
Trans-Activators
Transcription Factors - immunology
Virology
Virus Replication - immunology
Virus
Human
Microbiology
JC virus
Polyomavirus
T-Lymphocyte
Cytotoxicity
Papovaviridae
Detection
Cytotoxic T lymphocyte
Virology
Online AccessGet full text
ISSN0022-538X
1098-5514
DOI10.1128/JVI.78.18.10206-10210.2004

Cover

Abstract Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
AbstractList The polyomavirus JC (JCV) infects 85% of healthy individuals, and its reactivation in a limited number of immunosuppressed people causes progressive multifocal leukoencephalopathy (PML), a severe demyelinating disease of the central nervous system. We hypothesized that JCV-specific cytotoxic T lymphocytes (CTLs) might control JCV replication in healthy individuals, blocking the evolution of PML. Using 51Cr release and tetramer staining assays, we show that 8 of 11 HLA-A*0201+ healthy subjects (73%) harbor detectable JCV-specific CD8+ CTLs that recognize one or two epitopes of JCV VP1 protein, the HLA-A*0201-restricted VP1p36 and VPp1100 epitopes. We determined that the frequency of JCV VP1 epitope-specific CTLs varied from less than 1/100,000 to 1/2,494 peripheral blood mononuclear cells. More individuals had JCV VP1-specific than cytomegalovirus-specific CTLs (8 of 11 subjects [73%] versus 2 of 10 subjects [20%], respectively). These results show that a CD8+-T-cell response against JCV is commonly found in immunocompetent people and suggest that these cells might protect against the development of PML.The polyomavirus JC (JCV) infects 85% of healthy individuals, and its reactivation in a limited number of immunosuppressed people causes progressive multifocal leukoencephalopathy (PML), a severe demyelinating disease of the central nervous system. We hypothesized that JCV-specific cytotoxic T lymphocytes (CTLs) might control JCV replication in healthy individuals, blocking the evolution of PML. Using 51Cr release and tetramer staining assays, we show that 8 of 11 HLA-A*0201+ healthy subjects (73%) harbor detectable JCV-specific CD8+ CTLs that recognize one or two epitopes of JCV VP1 protein, the HLA-A*0201-restricted VP1p36 and VPp1100 epitopes. We determined that the frequency of JCV VP1 epitope-specific CTLs varied from less than 1/100,000 to 1/2,494 peripheral blood mononuclear cells. More individuals had JCV VP1-specific than cytomegalovirus-specific CTLs (8 of 11 subjects [73%] versus 2 of 10 subjects [20%], respectively). These results show that a CD8+-T-cell response against JCV is commonly found in immunocompetent people and suggest that these cells might protect against the development of PML.
The polyomavirus JC (JCV) infects 85% of healthy individuals, and its reactivation in a limited number of immunosuppressed people causes progressive multifocal leukoencephalopathy (PML), a severe demyelinating disease of the central nervous system. We hypothesized that JCV-specific cytotoxic T lymphocytes (CTLs) might control JCV replication in healthy individuals, blocking the evolution of PML. Using 51 Cr release and tetramer staining assays, we show that 8 of 11 HLA-A*0201 + healthy subjects (73%) harbor detectable JCV-specific CD8 + CTLs that recognize one or two epitopes of JCV VP1 protein, the HLA-A*0201-restricted VP1 p36 and VP1 p100 epitopes. We determined that the frequency of JCV VP1 epitope-specific CTLs varied from less than 1/100,000 to 1/2,494 peripheral blood mononuclear cells. More individuals had JCV VP1-specific than cytomegalovirus-specific CTLs (8 of 11 subjects [73%] versus 2 of 10 subjects [20%], respectively). These results show that a CD8 + -T-cell response against JCV is commonly found in immunocompetent people and suggest that these cells might protect against the development of PML.
The polyomavirus JC (JCV) infects 85% of healthy individuals, and its reactivation in a limited number of immunosuppressed people causes progressive multifocal leukoencephalopathy (PML), a severe demyelinating disease of the central nervous system. We hypothesized that JCV-specific cytotoxic T lymphocytes (CTLs) might control JCV replication in healthy individuals, blocking the evolution of PML. Using 51Cr release and tetramer staining assays, we show that 8 of 11 HLA-A*0201+ healthy subjects (73%) harbor detectable JCV-specific CD8+ CTLs that recognize one or two epitopes of JCV VP1 protein, the HLA-A*0201-restricted VP1p36 and VPp1100 epitopes. We determined that the frequency of JCV VP1 epitope-specific CTLs varied from less than 1/100,000 to 1/2,494 peripheral blood mononuclear cells. More individuals had JCV VP1-specific than cytomegalovirus-specific CTLs (8 of 11 subjects [73%] versus 2 of 10 subjects [20%], respectively). These results show that a CD8+-T-cell response against JCV is commonly found in immunocompetent people and suggest that these cells might protect against the development of PML.
The polyomavirus JC (JCV) infects 85% of healthy individuals, and its reactivation in a limited number of immunosuppressed people causes progressive multifocal leukoencephalopathy (PML), a severe demyelinating disease of the central nervous system. We hypothesized that JCV-specific cytotoxic T lymphocytes (CTLs) might control JCV replication in healthy individuals, blocking the evolution of PML. Using super(51)Cr release and tetramer staining assays, we show that 8 of 11 HLA-A*0201 super(+) healthy subjects (73%) harbor detectable JCV-specific CD8 super(+) CTLs that recognize one or two epitopes of JCV VP1 protein, the HLA-A*0201-restricted VP1 sub(p36) and VP1 sub(p100) epitopes. We determined that the frequency of JCV VP1 epitope-specific CTLs varied from less than 1/100,000 to 1/2,494 peripheral blood mononuclear cells. More individuals had JCV VP1-specific than cytomegalovirus-specific CTLs (8 of 11 subjects [73%] versus 2 of 10 subjects [20%], respectively). These results show that a CD8 super(+)-T-cell response against JCV is commonly found in immunocompetent people and suggest that these cells might protect against the development of PML.
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
Author I. J. Koralnik
R. A. Du Pasquier
Y. Zheng
J. Jean-Jacques
N. L. Letvin
J. Gordon
K. Khalili
J. E. Schmitz
AuthorAffiliation Division of Viral Pathogenesis, 1 Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, 2 Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania 3
AuthorAffiliation_xml – name: Division of Viral Pathogenesis, 1 Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, 2 Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania 3
Author_xml – sequence: 1
  givenname: R. A.
  surname: Du Pasquier
  fullname: Du Pasquier, R. A.
  organization: Division of Viral Pathogenesis, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
– sequence: 2
  givenname: J. E.
  surname: Schmitz
  fullname: Schmitz, J. E.
  organization: Division of Viral Pathogenesis
– sequence: 3
  givenname: J.
  surname: Jean-Jacques
  fullname: Jean-Jacques, J.
  organization: Division of Viral Pathogenesis
– sequence: 4
  givenname: Y.
  surname: Zheng
  fullname: Zheng, Y.
  organization: Division of Viral Pathogenesis
– sequence: 5
  givenname: J.
  surname: Gordon
  fullname: Gordon, J.
  organization: Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania
– sequence: 6
  givenname: K.
  surname: Khalili
  fullname: Khalili, K.
  organization: Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania
– sequence: 7
  givenname: N. L.
  surname: Letvin
  fullname: Letvin, N. L.
  organization: Division of Viral Pathogenesis
– sequence: 8
  givenname: I. J.
  surname: Koralnik
  fullname: Koralnik, I. J.
  organization: Division of Viral Pathogenesis, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16072831$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/15331755$$D View this record in MEDLINE/PubMed
BookMark eNqNkV1v0zAUhi00xLrBX0ARCO5S_B0HCQlUGOtUxAVj4s5yHGfxlMTFdgr593PX7gNuQLJsS-d5zzl63yNwMLjBAPACwTlCWLw5u1jOCzFH6UAMeZ7uVMIQ0kdghmApcsYQPQAzCDHOGRE_DsFRCFcQIko5fQIOESMEFYzNwJePJhodrRsy12Rni-zC-jHk39ZG28bqbDFFF93v9DvPVlO_bp2eogmZHbJTo7rYTtlyqO3G1qPqwlPwuEmPebZ_j8H3k0_ni9N89fXzcvFhlWuGYMwxRqqua4NprUvONW8w0phoVVECy0oUGpW0KoyuVcEqkwpKwYZDRjTE1JTkGLzb9V2PVW9qbYboVSfX3vbKT9IpK_-sDLaVl24jky8l3-pf7_Xe_RxNiLK3QZuuU4NxY5Cci2Rpgf8JIgEZK0qYwOcPN7pb5dbpBLzaAypo1TVeDdqGe46ncYKgxL3dcdq7ELxp7hEot_HLFL8sRBotb-KXN_HLbfxJ_P4vsbZRbdNNLtju_1q83LVo7WX7y3ojVejl1cY-FJBrxtbDaw
CitedBy_id crossref_primary_10_1002_eji_200939601
crossref_primary_10_1111_j_1468_1331_2011_03597_x
crossref_primary_10_1007_s00415_018_9140_0
crossref_primary_10_1007_s13365_016_0432_9
crossref_primary_10_2217_17460794_2_3_255
crossref_primary_10_1128_JVI_79_17_11170_11178_2005
crossref_primary_10_1038_nrd1743
crossref_primary_10_1093_intimm_dxm076
crossref_primary_10_1016_S0035_3787_06_74981_5
crossref_primary_10_1097_01_aids_0000194804_97164_86
crossref_primary_10_1002_ana_20933
crossref_primary_10_1089_apc_2005_19_486
crossref_primary_10_1002_eji_201545632
crossref_primary_10_1016_j_jcyt_2014_04_003
crossref_primary_10_1093_brain_awr206
crossref_primary_10_1002_ana_24471
crossref_primary_10_1212_WNL_0b013e31823b9b27
crossref_primary_10_1016_j_jneuroim_2006_04_003
crossref_primary_10_1002_ccr3_1816
crossref_primary_10_1128_JVI_02803_12
crossref_primary_10_1128_JVI_80_7_3495_3505_2006
crossref_primary_10_1080_1040841X_2016_1189873
crossref_primary_10_1016_j_virol_2006_02_040
crossref_primary_10_3389_fimmu_2014_00646
crossref_primary_10_1097_QAD_0b013e32830a5043
crossref_primary_10_1099_vir_0_82094_0
crossref_primary_10_1016_S1474_4422_10_70040_5
crossref_primary_10_1056_NEJMe058212
crossref_primary_10_2165_11537510_000000000_00000
crossref_primary_10_1016_j_neurol_2014_07_005
crossref_primary_10_1007_s13365_013_0222_6
crossref_primary_10_1016_j_ncl_2008_03_007
crossref_primary_10_1186_1479_5876_10_248
crossref_primary_10_1517_14728222_10_4_489
crossref_primary_10_1099_jmmcr_0_005053
crossref_primary_10_1111_neup_12203
crossref_primary_10_1016_S1474_4422_10_70006_5
crossref_primary_10_1016_j_clineuro_2007_05_009
crossref_primary_10_3390_v12101156
crossref_primary_10_1111_j_1600_6143_2005_00800_x
crossref_primary_10_1111_j_0105_2896_2006_00395_x
crossref_primary_10_1128_JVI_00614_10
crossref_primary_10_1128_JVI_01809_06
crossref_primary_10_7554_eLife_61056
crossref_primary_10_1056_NEJMe058122
crossref_primary_10_1002_ana_26198
crossref_primary_10_1111_j_1750_3639_2006_00042_x
crossref_primary_10_1093_brain_awr268
crossref_primary_10_1111_apm_12128
crossref_primary_10_1016_S1474_4422_10_70124_1
crossref_primary_10_1016_j_jneuroim_2010_09_021
crossref_primary_10_1042_CS20050278
crossref_primary_10_1212_01_wnl_0000257832_38943_2b
crossref_primary_10_1016_S1473_3099_09_70226_9
crossref_primary_10_4137_CMT_S4013
crossref_primary_10_1097_QAI_0b013e31825a313c
crossref_primary_10_1212_WNL_0b013e3182a84207
crossref_primary_10_1007_s00430_015_0390_5
crossref_primary_10_1007_s10875_021_01205_1
crossref_primary_10_1097_WCO_0b013e3283398c96
crossref_primary_10_1002_art_27687
crossref_primary_10_4161_mabs_1_6_9884
crossref_primary_10_1002_rmv_1866
crossref_primary_10_1016_j_bbmt_2014_03_018
crossref_primary_10_1177_0961203308089445
crossref_primary_10_1111_j_1552_6569_2007_00106_x
crossref_primary_10_1080_13550280500513325
Cites_doi 10.1086/514032
10.1080/13550280390195388
10.1128/jvi.70.11.7569-7579.1996
10.1007/BF00375376
10.1097/00002030-200307040-00004
10.1128/JVI.74.17.8140-8150.2000
10.1128/JVI.77.22.11918-11926.2003
10.4049/jimmunol.149.11.3580
10.1182/blood.V90.5.1751
10.1080/13550280152537175
10.1016/S0140-6736(71)91777-6
10.1128/JVI.75.7.3483-3487.2001
10.1080/146532402317251518
10.4049/jimmunol.162.3.1827
10.1084/jem.188.6.1047
10.1006/viro.1996.0424
10.1093/brain/awh215
10.1084/jem.180.4.1283
10.4049/jimmunol.168.1.499
10.1212/WNL.54.3.743
10.1182/blood.V98.3.754
10.4049/jimmunol.167.8.4450
ContentType Journal Article
Copyright 2004 INIST-CNRS
Copyright 2004 American Society for Microbiology
Copyright © 2004, American Society for Microbiology 2004
Copyright_xml – notice: 2004 INIST-CNRS
– notice: Copyright 2004 American Society for Microbiology
– notice: Copyright © 2004, American Society for Microbiology 2004
DBID AAYXX
CITATION
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
7T5
7U9
H94
7X8
5PM
DOI 10.1128/JVI.78.18.10206-10210.2004
DatabaseName CrossRef
Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Immunology Abstracts
Virology and AIDS Abstracts
AIDS and Cancer Research Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
AIDS and Cancer Research Abstracts
Immunology Abstracts
Virology and AIDS Abstracts
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
CrossRef

MEDLINE
AIDS and Cancer Research Abstracts
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1098-5514
EndPage 10210
ExternalDocumentID PMC514969
15331755
16072831
10_1128_JVI_78_18_10206_10210_2004
jvi_78_18_10206
Genre Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S
Journal Article
GrantInformation_xml – fundername: NINDS NIH HHS
  grantid: R01 NS/AI 041198
– fundername: NIAID NIH HHS
  grantid: P30-AI28691
– fundername: NINDS NIH HHS
  grantid: NS 047029
– fundername: NINDS NIH HHS
  grantid: R01 NS047029
– fundername: NIAID NIH HHS
  grantid: P30 AI028691
– fundername: NINDS NIH HHS
  grantid: R01 NS041198
GroupedDBID ---
-~X
.55
.GJ
0R~
18M
29L
2WC
39C
3O-
4.4
53G
5GY
5RE
5VS
85S
AAFWJ
AAGFI
AAYXX
ABPPZ
ACGFO
ACNCT
ADBBV
AENEX
AFFNX
AGVNZ
AI.
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BTFSW
C1A
CITATION
CS3
DIK
E3Z
EBS
EJD
F5P
FRP
GX1
H13
HYE
HZ~
IH2
KQ8
MVM
N9A
O9-
OHT
OK1
P2P
RHI
RNS
RPM
RSF
TR2
UPT
VH1
W2D
W8F
WH7
WOQ
X7M
Y6R
YQT
ZGI
~02
~KM
41~
6TJ
AAYJJ
ADXHL
D0S
IQODW
ZXP
CGR
CUY
CVF
ECM
EIF
NPM
PKN
RHF
UCJ
7T5
7U9
H94
7X8
5PM
ID FETCH-LOGICAL-c510t-221addde24dc966c6f21c23cab4309b87c194b7ecda75be3caaa0f6053c024e93
ISSN 0022-538X
IngestDate Thu Aug 21 18:29:39 EDT 2025
Fri Sep 05 07:12:43 EDT 2025
Fri Sep 05 03:36:39 EDT 2025
Wed Feb 19 01:53:45 EST 2025
Mon Jul 21 09:14:29 EDT 2025
Tue Jul 01 00:56:44 EDT 2025
Thu Apr 24 23:05:43 EDT 2025
Wed May 18 15:31:24 EDT 2016
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 18
Keywords Virus
Human
Microbiology
JC virus
Polyomavirus
T-Lymphocyte
Cytotoxicity
Papovaviridae
Detection
Cytotoxic T lymphocyte
Virology
Language English
License CC BY 4.0
Copyright 2004 American Society for Microbiology
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c510t-221addde24dc966c6f21c23cab4309b87c194b7ecda75be3caaa0f6053c024e93
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
Corresponding author. Mailing address: Division of Viral Pathogenesis and Department of Neurology, Research East, Room 213B, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215. Phone: (617) 667-1568. Fax: (617) 667-8210. E-mail: ikoralni@bidmc.harvard.edu.
Present address: Division of Neurology and Division of Immunology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
OpenAccessLink http://doi.org/10.1128/JVI.78.18.10206-10210.2004
PMID 15331755
PQID 18055790
PQPubID 23462
PageCount 5
ParticipantIDs highwire_asm_jvi_78_18_10206
proquest_miscellaneous_66821072
pubmed_primary_15331755
proquest_miscellaneous_18055790
pubmedcentral_primary_oai_pubmedcentral_nih_gov_514969
pascalfrancis_primary_16072831
crossref_primary_10_1128_JVI_78_18_10206_10210_2004
crossref_citationtrail_10_1128_JVI_78_18_10206_10210_2004
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2004-09-01
PublicationDateYYYYMMDD 2004-09-01
PublicationDate_xml – month: 09
  year: 2004
  text: 2004-09-01
  day: 01
PublicationDecade 2000
PublicationPlace Washington, DC
PublicationPlace_xml – name: Washington, DC
– name: United States
PublicationTitle Journal of Virology
PublicationTitleAlternate J Virol
PublicationYear 2004
Publisher American Society for Microbiology
Publisher_xml – name: American Society for Microbiology
References e_1_3_2_26_2
(e_1_3_2_23_2) 1999; 162
(e_1_3_2_16_2) 1993; 6
e_1_3_2_20_2
e_1_3_2_21_2
e_1_3_2_22_2
e_1_3_2_24_2
e_1_3_2_25_2
(e_1_3_2_17_2) 1983
(e_1_3_2_19_2) 1992; 149
e_1_3_2_9_2
e_1_3_2_15_2
e_1_3_2_8_2
e_1_3_2_7_2
e_1_3_2_6_2
e_1_3_2_18_2
(e_1_3_2_13_2) 1965; 5470
e_1_3_2_10_2
e_1_3_2_5_2
e_1_3_2_11_2
e_1_3_2_4_2
e_1_3_2_12_2
e_1_3_2_3_2
e_1_3_2_2_2
e_1_3_2_14_2
4104715 - Lancet. 1971 Jun 19;1(7712):1257-60
12824781 - AIDS. 2003 Jul 4;17(10):1443-9
8892876 - J Virol. 1996 Nov;70(11):7569-79
10680816 - Neurology. 2000 Feb 8;54(3):743-6
4284491 - Br Med J. 1965 Nov 6;2(5470):1099-102
3872841 - Immunogenetics. 1985;21(3):235-46
11238876 - J Virol. 2001 Apr;75(7):3483-7
11468176 - Blood. 2001 Aug 1;98(3):754-61
15215217 - Brain. 2004 Sep;127(Pt 9):1970-8
11751998 - J Immunol. 2002 Jan 1;168(1):499-504
9743523 - J Exp Med. 1998 Sep 21;188(6):1047-54
11591771 - J Immunol. 2001 Oct 15;167(8):4450-7
12709872 - J Neurovirol. 2003;9 Suppl 1:47-53
9973448 - J Immunol. 1999 Feb 1;162(3):1827-35
11517410 - J Neurovirol. 2001 Aug;7(4):318-22
11953040 - Cytotherapy. 2002;4(1):41-8
14581528 - J Virol. 2003 Nov;77(22):11918-26
9207375 - J Infect Dis. 1997 Jul;176(1):250-4
8806513 - Virology. 1996 Aug 1;222(1):293-6
1331239 - J Immunol. 1992 Dec 1;149(11):3580-7
8381231 - Mod Pathol. 1993 Jan;6(1):25-32
7523570 - J Exp Med. 1994 Oct 1;180(4):1283-93
9292508 - Blood. 1997 Sep 1;90(5):1751-67
10933725 - J Virol. 2000 Sep;74(17):8140-50
References_xml – ident: e_1_3_2_25_2
  doi: 10.1086/514032
– ident: e_1_3_2_2_2
  doi: 10.1080/13550280390195388
– volume: 5470
  start-page: 1099
  year: 1965
  ident: e_1_3_2_13_2
  publication-title: Br. Med. J.
– ident: e_1_3_2_26_2
  doi: 10.1128/jvi.70.11.7569-7579.1996
– ident: e_1_3_2_22_2
  doi: 10.1007/BF00375376
– ident: e_1_3_2_11_2
  doi: 10.1097/00002030-200307040-00004
– ident: e_1_3_2_12_2
  doi: 10.1128/JVI.74.17.8140-8150.2000
– ident: e_1_3_2_8_2
  doi: 10.1128/JVI.77.22.11918-11926.2003
– volume: 149
  start-page: 3580
  year: 1992
  ident: e_1_3_2_19_2
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.149.11.3580
– ident: e_1_3_2_6_2
  doi: 10.1182/blood.V90.5.1751
– ident: e_1_3_2_7_2
  doi: 10.1080/13550280152537175
– ident: e_1_3_2_18_2
  doi: 10.1016/S0140-6736(71)91777-6
– ident: e_1_3_2_15_2
  doi: 10.1128/JVI.75.7.3483-3487.2001
– ident: e_1_3_2_5_2
  doi: 10.1080/146532402317251518
– volume: 162
  start-page: 1827
  year: 1999
  ident: e_1_3_2_23_2
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.162.3.1827
– ident: e_1_3_2_20_2
  doi: 10.1084/jem.188.6.1047
– ident: e_1_3_2_3_2
  doi: 10.1006/viro.1996.0424
– volume: 6
  start-page: 25
  year: 1993
  ident: e_1_3_2_16_2
  publication-title: Mod. Pathol.
– ident: e_1_3_2_9_2
  doi: 10.1093/brain/awh215
– ident: e_1_3_2_24_2
  doi: 10.1084/jem.180.4.1283
– ident: e_1_3_2_14_2
  doi: 10.4049/jimmunol.168.1.499
– ident: e_1_3_2_21_2
  doi: 10.1212/WNL.54.3.743
– ident: e_1_3_2_10_2
  doi: 10.1182/blood.V98.3.754
– ident: e_1_3_2_4_2
  doi: 10.4049/jimmunol.167.8.4450
– start-page: 29
  year: 1983
  ident: e_1_3_2_17_2
  publication-title: Polyomaviruses and human neurological diseases
– reference: 14581528 - J Virol. 2003 Nov;77(22):11918-26
– reference: 9973448 - J Immunol. 1999 Feb 1;162(3):1827-35
– reference: 3872841 - Immunogenetics. 1985;21(3):235-46
– reference: 10680816 - Neurology. 2000 Feb 8;54(3):743-6
– reference: 10933725 - J Virol. 2000 Sep;74(17):8140-50
– reference: 1331239 - J Immunol. 1992 Dec 1;149(11):3580-7
– reference: 9207375 - J Infect Dis. 1997 Jul;176(1):250-4
– reference: 11517410 - J Neurovirol. 2001 Aug;7(4):318-22
– reference: 11591771 - J Immunol. 2001 Oct 15;167(8):4450-7
– reference: 8381231 - Mod Pathol. 1993 Jan;6(1):25-32
– reference: 11751998 - J Immunol. 2002 Jan 1;168(1):499-504
– reference: 8892876 - J Virol. 1996 Nov;70(11):7569-79
– reference: 8806513 - Virology. 1996 Aug 1;222(1):293-6
– reference: 9743523 - J Exp Med. 1998 Sep 21;188(6):1047-54
– reference: 11953040 - Cytotherapy. 2002;4(1):41-8
– reference: 9292508 - Blood. 1997 Sep 1;90(5):1751-67
– reference: 12709872 - J Neurovirol. 2003;9 Suppl 1:47-53
– reference: 12824781 - AIDS. 2003 Jul 4;17(10):1443-9
– reference: 15215217 - Brain. 2004 Sep;127(Pt 9):1970-8
– reference: 11468176 - Blood. 2001 Aug 1;98(3):754-61
– reference: 4104715 - Lancet. 1971 Jun 19;1(7712):1257-60
– reference: 4284491 - Br Med J. 1965 Nov 6;2(5470):1099-102
– reference: 7523570 - J Exp Med. 1994 Oct 1;180(4):1283-93
– reference: 11238876 - J Virol. 2001 Apr;75(7):3483-7
SSID ssj0014464
Score 2.0825822
Snippet Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
The polyomavirus JC (JCV) infects 85% of healthy individuals, and its reactivation in a limited number of immunosuppressed people causes progressive multifocal...
SourceID pubmedcentral
proquest
pubmed
pascalfrancis
crossref
highwire
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 10206
SubjectTerms Adult
Biological and medical sciences
Cytomegalovirus
Cytomegalovirus - immunology
DNA-Binding Proteins - immunology
Fundamental and applied biological sciences. Psychology
HLA-A Antigens - metabolism
HLA-A2 Antigen
Humans
Immunocompetence
Immunodominant Epitopes
JC virus
JC Virus - immunology
JC Virus - pathogenicity
JC Virus - physiology
Leukoencephalopathy, Progressive Multifocal - immunology
Leukoencephalopathy, Progressive Multifocal - prevention & control
Leukoencephalopathy, Progressive Multifocal - virology
Microbiology
Miscellaneous
Pathogenesis and Immunity
Plant Proteins
Polyomavirus
T-Lymphocytes, Cytotoxic - immunology
Trans-Activators
Transcription Factors - immunology
Virology
Virus Replication - immunology
Title Detection of JC Virus-Specific Cytotoxic T Lymphocytes in Healthy Individuals
URI http://jvi.asm.org/content/78/18/10206.abstract
https://www.ncbi.nlm.nih.gov/pubmed/15331755
https://www.proquest.com/docview/18055790
https://www.proquest.com/docview/66821072
https://pubmed.ncbi.nlm.nih.gov/PMC514969
Volume 78
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb5RAFJ6sNSa-GO9Fa-XBtw0r9xkezba1Jdv6IG1WX8gwDFmMBS1gXH-9Z4bLDmY3VhNCCAzDhO_jzDnMuSD0Jk0TN6NY-OGQzHBhCjOSxPcNQhMeZImJU-lNeH7hn1664dJbTiZnitdSUycz9mtrXMn_oArnAFcRJfsPyA6dwgk4BnxhDwjD_lYYH_Gas17lC-fTq_ymqQxZUj7L2XS-rsu6_AlH0XSxBthKtq6lA1YXfbQG8dDHY1U71FQRB6f-eT9qQOusvjd5VzR5YMBHtrrOZXVYJX1nyGlhhJSJ2We0CPV5xVsp82n038EdHKvUOAAQl0tVlmKicoYokhFYYPrKNCtKipvbZbgt4hLCq7MZJjOLzOSdhmwv7fnNzNWv1l98iE8uF4s4Ol5Gd9BdG2O5Yv9-OXj7CKvX7RPHi0F3-WfhWW93P2msq_T5o4X7LK3gC8ra0ifbbJM_XWwVnSV6iB50KOrvWuY8QhNePEb32vKj6yfofOCPXmZ6ONfH_NEH_uiRrvBHzwu944-u8Ocpujw5juanRldew2AgiGvDti2Y3FJuuykDo5f5mW0x22E0cR0zSAhmVuAmmLOUYi_hcIFSMwPz12Gg2PHAeYb2irLg-0jPAi9zvNTi4k0TjyReIDoijFsppZxoKOhfZMy63POiBMrXWNqgNokBhBiT2IJNgBBLEESNVFdDznDvtzYDy63uOujximl1HX_5kastNXQ4wnDTs29i0LgtDb3uQY1B4IpVNFrwsqmgC5G2LjB3t_B9AsPAtoaetyTY9A7GFejrnob8ET2GBiLZ-_hKka9k0ncwbAI_ePHXYb1E9zdf6wHaq28a_gr05jo5lF_Eb-vGvlo
linkProvider Geneva Foundation for Medical Education and Research
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Detection+of+JC+Virus-Specific+Cytotoxic+T+Lymphocytes+in+Healthy+Individuals&rft.jtitle=Journal+of+virology&rft.au=Du+Pasquier%2C+RA&rft.au=Schmitz%2C+JE&rft.au=Jean-Jacques%2C+J&rft.au=Zheng%2C+Y&rft.date=2004-09-01&rft.issn=0022-538X&rft.volume=78&rft.issue=18&rft.spage=10206&rft.epage=10210&rft_id=info:doi/10.1128%2FJVI.78.18.10206-10210.2004&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-538X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-538X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-538X&client=summon