Clinical Implications of Phosphorylated STAT3 Expression in De Novo Diffuse Large B-cell Lymphoma

• Published in: Clinical cancer research Vol. 20; no. 19; pp. 5113 - 5123
• Main Authors: Ok, Chi Young, Chen, Jiayu, Xu-Monette, Zijun Y., Tzankov, Alexandar, Manyam, Ganiraju C., Li, Ling, Visco, Carlo, Montes-Moreno, Santiago, Dybkær, Karen, Chiu, April, Orazi, Attilio, Zu, Youli, Bhagat, Govind, Richards, Kristy L., Hsi, Eric D., Choi, William W.L., van Krieken, J. Han, Huh, Jooryung, Zhao, Xiaoying, Ponzoni, Maurilio, Ferreri, Andrés J.M., Bertoni, Francesco, Farnen, John P., Møller, Michael B., Piris, Miguel A., Winter, Jane N., Medeiros, L. Jeffrey, Young, Ken H.
• Format: Journal Article
• Language: English
• Published: United States 01.10.2014
• Subjects: Adult; Aged; Antibodies, Monoclonal, Murine-Derived - therapeutic use; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Cohort Studies; Cyclin D1 - genetics; Cyclin D1 - metabolism; Cyclophosphamide - therapeutic use; Doxorubicin - therapeutic use; Female; Gene Expression; Genes, bcl-2; Genes, myc; Humans; Lymphoma, Large B-Cell, Diffuse - drug therapy; Lymphoma, Large B-Cell, Diffuse - genetics; Lymphoma, Large B-Cell, Diffuse - metabolism; Lymphoma, Large B-Cell, Diffuse - mortality; Lymphoma, Large B-Cell, Diffuse - pathology; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; NF-kappa B - genetics; NF-kappa B - metabolism; Phosphorylation; Prednisone - therapeutic use; Prognosis; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; Signal Transduction; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; Tumor Burden; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Vincristine - therapeutic use

Purpose: Activated signal transducer and activator of transcription 3 (STAT3) regulates tumor growth, invasion, cell proliferation, angiogenesis, immune response, and survival. Data regarding expression of phosphorylated (activated) STAT3 in diffuse large B-cell lymphoma (DLBCL) and the impact of ph...