Aging induces muscle-specific impairment of endothelium-dependent dilation in skeletal muscle feed arteries

• Published in: Journal of applied physiology (1985) Vol. 93; no. 5; pp. 1685 - 1690
• Main Authors: Woodman, Christopher R, Price, Elmer M, Laughlin, M. Harold
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Physiological Soc 01.11.2002; American Physiological Society
• Subjects: Aging; Aging - physiology; Animals; Arteries - physiology; Biological and medical sciences; Blood vessels; Blood vessels and receptors; Endothelium, Vascular - physiology; Fundamental and applied biological sciences. Psychology; Male; Muscle, Skeletal - blood supply; Nitric oxide; Nitric Oxide Synthase - metabolism; Nitric Oxide Synthase Type III; Rats; Rats, Inbred F344; Sodium; Superoxide Dismutase - metabolism; Superoxide Dismutase-1; Vasodilation - physiology; Vertebrates: cardiovascular system; Senescence; Rat; Rodentia; Striated muscle; Soleus muscle; Artery; Vasodilation; Endothelium; Vasomotricity; Vertebrata; Mammalia; sodium nitroprusside; Blood vessel; Nitric oxide; superoxide dismutase; endothelial nitric oxide synthase; Circulatory system; Gastrocnemius muscle; acetylcholine

Departments of Veterinary Biomedical Sciences and Physiology and Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri 65211 We tested the hypothesis that aging decreases endothelium-dependent vasodilation in feed arteries perfusing rat skeletal muscle. In addition, we te...