Linkage between the leader sequence and leader RNA production in Borna disease virus-infected cells

• Published in: Virology (New York, N.Y.) Vol. 510; pp. 104 - 110
• Main Authors: Honda, Tomoyuki, Sofuku, Kozue, Kojima, Shohei, Yamamoto, Yusuke, Ohtaki, Naohiro, Tomonaga, Keizo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2017
• Subjects: 3' Untranslated Regions; 3′-untranslated region; 5' untranslated regions; Borna disease; Borna disease virus; Borna disease virus - genetics; chronic diseases; Gene Expression Profiling; genes; Leader RNAs; mutation; nucleoproteins; RNA, Viral - biosynthesis; Transcription; transcription (genetics); Transcription, Genetic; Viral polymerase; virus replication; Viral polymerase; Transcription; 3′-untranslated region; Leader RNAs; Borna disease virus

The 3′-untranslated region (UTR) of the non-segmented, negative-strand (NNS) RNA viral genome is called the leader sequence, and functions as the promoter for viral replication and transcription. NNS RNA viruses also use the sequence as a template to synthesize leader RNAs (leRNAs) with unknown func...