Dynamic structure mediates halophilic adaptation of a DNA polymerase from the deep-sea brines of the Red Sea

• Published in: The FASEB journal Vol. 32; no. 6; p. 3346
• Main Authors: Takahashi, Masateru, Takahashi, Etsuko, Joudeh, Luay I, Marini, Monica, Das, Gobind, Elshenawy, Mohamed M, Akal, Anastassja, Sakashita, Kosuke, Alam, Intikhab, Tehseen, Muhammad, Sobhy, Mohamed A, Stingl, Ulrich, Merzaban, Jasmeen S, Di Fabrizio, Enzo, Hamdan, Samir M
• Format: Journal Article
• Language: English
• Published: United States 01.06.2018
• Subjects: Archaeal Proteins - chemistry; DNA-Directed DNA Polymerase - chemistry; Indian Ocean; Molecular Dynamics Simulation; Thermococcus - enzymology; Indian Ocean; structural adaptation; halophilic enzymes; thermophilic enzymes; structure dynamism; DNA polymerase engineering

The deep-sea brines of the Red Sea are remote and unexplored environments characterized by high temperatures, anoxic water, and elevated concentrations of salt and heavy metals. This environment provides a rare system to study the interplay between halophilic and thermophilic adaptation in biologic...