25-Hydroxyvitamin D Deficiency Is Associated With Inflammation-Linked Vascular Endothelial Dysfunction in Middle-Aged and Older Adults

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 57; no. 1; pp. 63 - 69
• Main Authors: Jablonski, Kristen L., Chonchol, Michel, Pierce, Gary L., Walker, Ashley E., Seals, Douglas R.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 01.01.2011; Lippincott Williams & Wilkins
• Subjects: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - analysis; Aged; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Blood vessels and receptors; Brachial Artery - physiopathology; Cardiology. Vascular system; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiopathology; Female; Fundamental and applied biological sciences. Psychology; Humans; Inflammation - metabolism; Inflammation - physiopathology; Interleukin-6 - analysis; Male; Medical sciences; Middle Aged; NF-kappa B - analysis; NF-kappa B - antagonists & inhibitors; Nitroglycerin - pharmacology; Receptors, Calcitriol - analysis; Salicylates - pharmacology; Vascular Diseases - etiology; Vascular Diseases - metabolism; Vasodilation - drug effects; Vasodilation - physiology; Vertebrates: cardiovascular system; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D - metabolism; Vitamin D Deficiency - complications; Vitamin D Deficiency - metabolism; Hypertension; endothelium-dependent dilation; Senescence; NFκB; Enzyme; VDR; Deficiency; Hydroxylase; Cardiovascular disease; Inflammation; interleukin-6; Endothelium; Interleukin 6; Oxidoreductases; aging; 1-α hydroxylase

We tested the hypothesis that vascular endothelial function, assessed by endothelium-dependent dilation, is related to serum vitamin D status among middle-aged and older adults without clinical disease, and that this is linked to inflammation. Brachial artery flow-mediated dilation, a measure of end...