Low cholesterol levels are associated with increasing risk of plasma cell neoplasm: A UK biobank cohort study
Background Plasma cell neoplasms are a group of hematologic neoplasms that often develop in the elderly population. The relationship between cholesterol levels and hematologic malignancy has been identified in population studies. However, it is still unclear if there is a relationship between choles...
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Published in | Cancer medicine (Malden, MA) Vol. 12; no. 22; pp. 20964 - 20975 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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United States
John Wiley & Sons, Inc
01.11.2023
John Wiley and Sons Inc Wiley |
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Abstract | Background
Plasma cell neoplasms are a group of hematologic neoplasms that often develop in the elderly population. The relationship between cholesterol levels and hematologic malignancy has been identified in population studies. However, it is still unclear if there is a relationship between cholesterol levels and plasma cell neoplasm in European ancestry.
Methods
Prospective cohorts included 502,507 individuals from the UK Biobank who were followed up to 2019 and assessed total cholesterol(TC) levels, low‐density lipoprotein (LDL) levels, high‐density lipoprotein (HDL) levels, apolipoprotein A (ApoA) and apolipoprotein B (ApoB) as risk factors for plasma cell neoplasms with Cox proportional hazard regression and restricted cubic spline model. We also used two‐sample Mendelian randomization to determine if the cholesterol level has a causal effect on developing plasma cell neoplasms.
Results
We observed 1819 plasma cell neoplasm cases during 14.2 years of follow‐up in the UK Biobank. We found higher blood serum cholesterol levels at baseline were associated with a lower risk of plasma cell neoplasm in our study. All lipid profiles we analyzed in this study were inversely associated with plasma cell neoplasm risk (all ptrend <0.005) but triglycerides did not have such association. However, there was no suggestive association of genetically predicted serum LDL, HDL, and total cholesterol levels with multiple myeloma.
Conclusion
Low serum total cholesterol, LDL, HDL, ApoA, and ApoB levels were all associated with increasing the risk of plasma cell neoplasm.
We found that cholesterol profiles such as total cholesterol, HDL, LDL, apolipoprotein A, and apolipoprotein B were inversely correlated with the risk of plasma neoplasms. |
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AbstractList | Abstract Background Plasma cell neoplasms are a group of hematologic neoplasms that often develop in the elderly population. The relationship between cholesterol levels and hematologic malignancy has been identified in population studies. However, it is still unclear if there is a relationship between cholesterol levels and plasma cell neoplasm in European ancestry. Methods Prospective cohorts included 502,507 individuals from the UK Biobank who were followed up to 2019 and assessed total cholesterol(TC) levels, low‐density lipoprotein (LDL) levels, high‐density lipoprotein (HDL) levels, apolipoprotein A (ApoA) and apolipoprotein B (ApoB) as risk factors for plasma cell neoplasms with Cox proportional hazard regression and restricted cubic spline model. We also used two‐sample Mendelian randomization to determine if the cholesterol level has a causal effect on developing plasma cell neoplasms. Results We observed 1819 plasma cell neoplasm cases during 14.2 years of follow‐up in the UK Biobank. We found higher blood serum cholesterol levels at baseline were associated with a lower risk of plasma cell neoplasm in our study. All lipid profiles we analyzed in this study were inversely associated with plasma cell neoplasm risk (all ptrend <0.005) but triglycerides did not have such association. However, there was no suggestive association of genetically predicted serum LDL, HDL, and total cholesterol levels with multiple myeloma. Conclusion Low serum total cholesterol, LDL, HDL, ApoA, and ApoB levels were all associated with increasing the risk of plasma cell neoplasm. Plasma cell neoplasms are a group of hematologic neoplasms that often develop in the elderly population. The relationship between cholesterol levels and hematologic malignancy has been identified in population studies. However, it is still unclear if there is a relationship between cholesterol levels and plasma cell neoplasm in European ancestry. Prospective cohorts included 502,507 individuals from the UK Biobank who were followed up to 2019 and assessed total cholesterol(TC) levels, low-density lipoprotein (LDL) levels, high-density lipoprotein (HDL) levels, apolipoprotein A (ApoA) and apolipoprotein B (ApoB) as risk factors for plasma cell neoplasms with Cox proportional hazard regression and restricted cubic spline model. We also used two-sample Mendelian randomization to determine if the cholesterol level has a causal effect on developing plasma cell neoplasms. We observed 1819 plasma cell neoplasm cases during 14.2 years of follow-up in the UK Biobank. We found higher blood serum cholesterol levels at baseline were associated with a lower risk of plasma cell neoplasm in our study. All lipid profiles we analyzed in this study were inversely associated with plasma cell neoplasm risk (all p <0.005) but triglycerides did not have such association. However, there was no suggestive association of genetically predicted serum LDL, HDL, and total cholesterol levels with multiple myeloma. Low serum total cholesterol, LDL, HDL, ApoA, and ApoB levels were all associated with increasing the risk of plasma cell neoplasm. We found that cholesterol profiles such as total cholesterol, HDL, LDL, apolipoprotein A, and apolipoprotein B were inversely correlated with the risk of plasma neoplasms. Background Plasma cell neoplasms are a group of hematologic neoplasms that often develop in the elderly population. The relationship between cholesterol levels and hematologic malignancy has been identified in population studies. However, it is still unclear if there is a relationship between cholesterol levels and plasma cell neoplasm in European ancestry. Methods Prospective cohorts included 502,507 individuals from the UK Biobank who were followed up to 2019 and assessed total cholesterol(TC) levels, low‐density lipoprotein (LDL) levels, high‐density lipoprotein (HDL) levels, apolipoprotein A (ApoA) and apolipoprotein B (ApoB) as risk factors for plasma cell neoplasms with Cox proportional hazard regression and restricted cubic spline model. We also used two‐sample Mendelian randomization to determine if the cholesterol level has a causal effect on developing plasma cell neoplasms. Results We observed 1819 plasma cell neoplasm cases during 14.2 years of follow‐up in the UK Biobank. We found higher blood serum cholesterol levels at baseline were associated with a lower risk of plasma cell neoplasm in our study. All lipid profiles we analyzed in this study were inversely associated with plasma cell neoplasm risk (all ptrend <0.005) but triglycerides did not have such association. However, there was no suggestive association of genetically predicted serum LDL, HDL, and total cholesterol levels with multiple myeloma. Conclusion Low serum total cholesterol, LDL, HDL, ApoA, and ApoB levels were all associated with increasing the risk of plasma cell neoplasm. We found that cholesterol profiles such as total cholesterol, HDL, LDL, apolipoprotein A, and apolipoprotein B were inversely correlated with the risk of plasma neoplasms. Abstract Background Plasma cell neoplasms are a group of hematologic neoplasms that often develop in the elderly population. The relationship between cholesterol levels and hematologic malignancy has been identified in population studies. However, it is still unclear if there is a relationship between cholesterol levels and plasma cell neoplasm in European ancestry. Methods Prospective cohorts included 502,507 individuals from the UK Biobank who were followed up to 2019 and assessed total cholesterol(TC) levels, low‐density lipoprotein (LDL) levels, high‐density lipoprotein (HDL) levels, apolipoprotein A (ApoA) and apolipoprotein B (ApoB) as risk factors for plasma cell neoplasms with Cox proportional hazard regression and restricted cubic spline model. We also used two‐sample Mendelian randomization to determine if the cholesterol level has a causal effect on developing plasma cell neoplasms. Results We observed 1819 plasma cell neoplasm cases during 14.2 years of follow‐up in the UK Biobank. We found higher blood serum cholesterol levels at baseline were associated with a lower risk of plasma cell neoplasm in our study. All lipid profiles we analyzed in this study were inversely associated with plasma cell neoplasm risk (all p trend <0.005) but triglycerides did not have such association. However, there was no suggestive association of genetically predicted serum LDL, HDL, and total cholesterol levels with multiple myeloma. Conclusion Low serum total cholesterol, LDL, HDL, ApoA, and ApoB levels were all associated with increasing the risk of plasma cell neoplasm. BackgroundPlasma cell neoplasms are a group of hematologic neoplasms that often develop in the elderly population. The relationship between cholesterol levels and hematologic malignancy has been identified in population studies. However, it is still unclear if there is a relationship between cholesterol levels and plasma cell neoplasm in European ancestry.MethodsProspective cohorts included 502,507 individuals from the UK Biobank who were followed up to 2019 and assessed total cholesterol(TC) levels, low-density lipoprotein (LDL) levels, high-density lipoprotein (HDL) levels, apolipoprotein A (ApoA) and apolipoprotein B (ApoB) as risk factors for plasma cell neoplasms with Cox proportional hazard regression and restricted cubic spline model. We also used two-sample Mendelian randomization to determine if the cholesterol level has a causal effect on developing plasma cell neoplasms.ResultsWe observed 1819 plasma cell neoplasm cases during 14.2 years of follow-up in the UK Biobank. We found higher blood serum cholesterol levels at baseline were associated with a lower risk of plasma cell neoplasm in our study. All lipid profiles we analyzed in this study were inversely associated with plasma cell neoplasm risk (all ptrend <0.005) but triglycerides did not have such association. However, there was no suggestive association of genetically predicted serum LDL, HDL, and total cholesterol levels with multiple myeloma.ConclusionLow serum total cholesterol, LDL, HDL, ApoA, and ApoB levels were all associated with increasing the risk of plasma cell neoplasm. |
Author | Li, Linfeng Niu, Ting Yu, Zhengyu Ren, Jianjun |
AuthorAffiliation | 2 Department of Otolaryngology‐Head and Neck Surgery, West China Hospital, West China Medical School Sichuan University Chengdu China 1 Department of Hematology, Institute of Hematology, West China Hospital Sichuan University Chengdu China |
AuthorAffiliation_xml | – name: 1 Department of Hematology, Institute of Hematology, West China Hospital Sichuan University Chengdu China – name: 2 Department of Otolaryngology‐Head and Neck Surgery, West China Hospital, West China Medical School Sichuan University Chengdu China |
Author_xml | – sequence: 1 givenname: Linfeng orcidid: 0009-0005-2975-3713 surname: Li fullname: Li, Linfeng organization: Sichuan University – sequence: 2 givenname: Zhengyu surname: Yu fullname: Yu, Zhengyu organization: Sichuan University – sequence: 3 givenname: Jianjun surname: Ren fullname: Ren, Jianjun email: jianjun.ren@scu.edu.cn organization: Sichuan University – sequence: 4 givenname: Ting surname: Niu fullname: Niu, Ting email: niuting@wchscu.cn organization: Sichuan University |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37908181$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_3390_biomedicines12030514 |
Cites_doi | 10.1200/JCO.2010.31.5200 10.1007/s00277-011-1246-8 10.1056/NEJMoa1201735 10.1038/s41588-018-0047-6 10.1016/j.plipres.2018.06.001 10.1038/ncomms11122 10.1016/j.bbalip.2021.159068 10.1023/B:MCBI.0000049134.69131.89 10.26508/lsa.202101317 10.1038/srep09495 10.6004/jnccn.2022.0002 10.1016/j.cccn.2005.04.003 10.1182/blood-2008-12-194241 10.7554/eLife.57191 10.1007/s11883-021-00906-7 10.1186/s13045-020-00963-6 10.1002/ajh.25778 10.1200/JCO.2016.68.3482 10.1002/ijc.24668 10.1016/j.jacc.2009.12.069 10.1111/j.1365-2362.2007.01849.x 10.1182/blood-2014-11-568881 10.1182/blood-2008-12-195008 10.1074/jbc.M113.468967 10.1126/science.1189731 10.1002/cam4.3937 10.1038/ni.3754 10.18637/jss.v045.i03 10.7554/eLife.34408 10.1016/j.jacl.2017.05.004 10.1038/s41375-020-01081-5 10.1002/sim.3618 10.3945/ajcn.115.124321 10.1093/cvr/cvu150 10.1016/j.semcancer.2020.10.007 10.1146/annurev-nutr-071811-150709 10.1002/ijc.30013 10.3390/cancers13030540 10.1161/ATVBAHA.114.304006 10.1158/0008-5472.CAN-07-0212 |
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Copyright | 2023 The Authors. published by John Wiley & Sons Ltd. 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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Keywords | cholesterol apolipoprotein UK Biobank plasma cell neoplasm |
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License | Attribution 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
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Notes | Jianjun Ren and Ting Niu contributed equally to this work as co‐corresponding authors. Linfeng Li and Zhengyu Yu contributed equally as co‐first authors of this article. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
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References | 2004; 266 2010; 55 2015; 5 2021; 23 2010; 328 2015; 125 2022; 1867 1995; 13 2005; 359 2013; 288 2009; 113 2020; 13 2022; 20 2016; 103 1989; 26 2012; 367 2021; 73 2012; 32 2007; 37 2016; 34 2009; 28 2018; 7 2021; 35 2021; 13 2018; 8 2016; 7 2012; 91 2021; 10 2022; 5 2020; 95 2020 2017; 11 2020; 9 2016; 138 2011; 45 2017; 18 2018; 50 2018; 71 2007; 67 2011; 29 2014; 103 2014; 34 2009; 125 e_1_2_10_23_1 Long J (e_1_2_10_6_1) 2018; 8 e_1_2_10_24_1 e_1_2_10_21_1 e_1_2_10_44_1 e_1_2_10_43_1 e_1_2_10_42_1 e_1_2_10_20_1 e_1_2_10_41_1 e_1_2_10_40_1 Bergsagel D (e_1_2_10_45_1) 1995; 13 e_1_2_10_2_1 e_1_2_10_4_1 e_1_2_10_18_1 e_1_2_10_3_1 e_1_2_10_19_1 e_1_2_10_16_1 e_1_2_10_39_1 e_1_2_10_5_1 e_1_2_10_17_1 e_1_2_10_38_1 e_1_2_10_8_1 e_1_2_10_14_1 e_1_2_10_37_1 e_1_2_10_7_1 e_1_2_10_15_1 e_1_2_10_36_1 e_1_2_10_12_1 e_1_2_10_35_1 e_1_2_10_9_1 e_1_2_10_13_1 e_1_2_10_34_1 e_1_2_10_10_1 e_1_2_10_33_1 e_1_2_10_11_1 Campion WM (e_1_2_10_22_1) 1989; 26 e_1_2_10_32_1 e_1_2_10_31_1 e_1_2_10_30_1 e_1_2_10_29_1 e_1_2_10_27_1 e_1_2_10_28_1 e_1_2_10_25_1 e_1_2_10_26_1 |
References_xml | – volume: 32 start-page: 161 year: 2012 end-page: 182 article-title: New roles of HDL in inflammation and hematopoiesis publication-title: Annu Rev Nutr – volume: 13 year: 2020 article-title: Low high‐density lipoprotein and increased risk of several cancers: 2 population‐based cohort studies including 116,728 individuals publication-title: J Hematol Oncol – volume: 113 start-page: 5418 year: 2009 end-page: 5422 article-title: A monoclonal gammopathy precedes multiple myeloma in most patients publication-title: Blood – volume: 266 start-page: 37 year: 2004 end-page: 56 article-title: Role of oxygen radicals in DNA damage and cancer incidence publication-title: Mol Cell Biochem – volume: 71 start-page: 54 year: 2018 end-page: 69 article-title: High density lipoprotein cholesterol and cancer: marker or causative? publication-title: Prog Lipid Res – volume: 13 start-page: 540 issue: 3 year: 2021 article-title: Lipid level, lipid variability, and risk of multiple myeloma: a Nationwide population‐based study of 3,527,776 subjects publication-title: Cancers (Basel) – volume: 328 start-page: 1689 year: 2010 end-page: 1693 article-title: ATP‐binding cassette transporters and HDL suppress hematopoietic stem cell proliferation publication-title: Science – volume: 11 start-page: 1073 year: 2017 end-page: 1081 article-title: Blood lipids profile and lung cancer risk in a meta‐analysis of prospective cohort studies publication-title: J Clin Lipidol – volume: 288 start-page: 21237 year: 2013 end-page: 21252 article-title: The cardioprotective protein apolipoprotein A1 promotes potent anti‐tumorigenic effects publication-title: J Biol Chem – volume: 10 start-page: 4054 year: 2021 end-page: 4065 article-title: Association between pre‐diagnostic serum albumin and cancer risk: results from a prospective population‐based study publication-title: Cancer Med – volume: 50 start-page: 390 year: 2018 end-page: 400 article-title: Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases publication-title: Nat Genet – volume: 367 start-page: 1792 year: 2012 end-page: 1802 article-title: Statin use and reduced cancer‐related mortality publication-title: N Engl J Med – volume: 28 start-page: 1982 year: 2009 end-page: 1998 article-title: Imputing missing covariate values for the cox model publication-title: Stat Med – volume: 5 year: 2015 article-title: Causal relevance of circulating high‐density lipoprotein cholesterol with cancer: a Mendelian randomization meta‐analysis publication-title: Sci Rep – volume: 73 start-page: 169 year: 2021 end-page: 177 article-title: HDL and cancer—causality still needs to be confirmed? Update 2020 publication-title: Semin Cancer Biol – volume: 26 start-page: 485 year: 1989 end-page: 486 article-title: Multiple imputation for nonresponse in surveys—Rubin, DB publication-title: J Marketing Res – volume: 37 start-page: 715 year: 2007 end-page: 723 article-title: Association of oxidative stress and PON1 with LDL and HDL particle size in middle‐aged subjects publication-title: Eur J Clin Invest – volume: 95 start-page: 652 year: 2020 end-page: 661 article-title: Statin use is associated with improved survival in multiple myeloma: a Swedish population‐based study of 4315 patients publication-title: Am J Hematol – volume: 13 start-page: 1 issue: suppl 2 year: 1995 end-page: 9 article-title: The incidence and epidemiology of plasma cell neoplasms publication-title: Stem Cells – volume: 45 start-page: 1 year: 2011 end-page: 67 article-title: Mice: multivariate imputation by chained equations in R publication-title: J Stat Softw – volume: 113 start-page: 5412 year: 2009 end-page: 5417 article-title: Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study publication-title: Blood – volume: 67 start-page: 5569 year: 2007 end-page: 5574 article-title: Serum high‐density lipoprotein cholesterol and risk of non‐hodgkin lymphoma publication-title: Cancer Res – volume: 125 start-page: 3049 year: 2015 end-page: 3058 article-title: Pathogenesis beyond the cancer clone(s) in multiple myeloma publication-title: Blood – volume: 103 start-page: 372 year: 2014 end-page: 383 article-title: HDL in innate and adaptive immunity publication-title: Cardiovasc Res – volume: 91 start-page: 83 year: 2012 end-page: 88 article-title: Low‐density lipoprotein cholesterol suppresses apoptosis in human multiple myeloma cells publication-title: Ann Hematol – volume: 35 start-page: 1356 year: 2021 end-page: 1364 article-title: Association between high‐density lipoprotein cholesterol level and risk of hematologic malignancy publication-title: Leukemia – volume: 20 start-page: 8 year: 2022 end-page: 19 article-title: NCCN guidelines(R) insights: multiple myeloma, Version 3.2022 publication-title: J Natl Compr Canc Netw – volume: 8 start-page: 778 year: 2018 end-page: 791 article-title: Lipid metabolism and carcinogenesis, cancer development publication-title: Am J Cancer Res – volume: 125 start-page: 2679 year: 2009 end-page: 2686 article-title: Serum cholesterol levels in relation to the incidence of cancer: the JPHC study cohorts publication-title: Int J Cancer – volume: 18 start-page: 843 year: 2017 end-page: 850 article-title: Nutrition, inflammation and cancer publication-title: Nat Immunol – volume: 7 year: 2018 article-title: The MR‐base platform supports systematic causal inference across the human phenome publication-title: eLife – year: 2020 – volume: 138 start-page: 2648 year: 2016 end-page: 2656 article-title: Apolipoproteins, lipids and risk of cancer publication-title: Int J Cancer – volume: 9 year: 2020 article-title: Predicting the effect of statins on cancer risk using genetic variants from a Mendelian randomization study in the UK Biobank publication-title: eLife – volume: 34 start-page: 1900 year: 2014 end-page: 1909 article-title: Regulation of high‐density lipoprotein on hematopoietic stem/progenitor cells in atherosclerosis requires scavenger receptor type BI expression publication-title: Arterioscler Thromb Vasc Biol – volume: 55 start-page: 2846 year: 2010 end-page: 2854 article-title: Baseline and on‐treatment high‐density lipoprotein cholesterol and the risk of cancer in randomized controlled trials of lipid‐altering therapy publication-title: J Am Coll Cardiol – volume: 359 start-page: 27 year: 2005 end-page: 45 article-title: Cholesteryl esters in malignancy publication-title: Clin Chim Acta – volume: 23 year: 2021 article-title: APOA1: a protein with multiple therapeutic functions publication-title: Curr Atheroscler Rep – volume: 5 year: 2022 article-title: The HDL particle composition determines its antitumor activity in pancreatic cancer publication-title: Life Sci Alliance – volume: 7 year: 2016 article-title: Genome‐wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA publication-title: Nat Commun – volume: 29 start-page: 1592 year: 2011 end-page: 1598 article-title: Total cholesterol and cancer risk in a large prospective study in Korea publication-title: J Clin Oncol – volume: 103 start-page: 1397 year: 2016 end-page: 1407 article-title: Lipid biomarkers and long‐term risk of cancer in the Women's Health Study publication-title: Am J Clin Nutr – volume: 34 start-page: 4008 year: 2016 end-page: 4014 article-title: Statins are associated with reduced mortality in multiple myeloma publication-title: J Clin Oncol – volume: 1867 year: 2022 article-title: High‐density lipoproteins: a promising tool against cancer publication-title: Biochim Biophys Acta Mol Cell Biol Lipids – ident: e_1_2_10_36_1 doi: 10.1200/JCO.2010.31.5200 – ident: e_1_2_10_39_1 doi: 10.1007/s00277-011-1246-8 – ident: e_1_2_10_34_1 doi: 10.1056/NEJMoa1201735 – ident: e_1_2_10_26_1 doi: 10.1038/s41588-018-0047-6 – volume: 13 start-page: 1 issue: 2 year: 1995 ident: e_1_2_10_45_1 article-title: The incidence and epidemiology of plasma cell neoplasms publication-title: Stem Cells contributor: fullname: Bergsagel D – ident: e_1_2_10_9_1 doi: 10.1016/j.plipres.2018.06.001 – ident: e_1_2_10_24_1 doi: 10.1038/ncomms11122 – ident: e_1_2_10_27_1 doi: 10.1016/j.bbalip.2021.159068 – ident: e_1_2_10_38_1 doi: 10.1023/B:MCBI.0000049134.69131.89 – ident: e_1_2_10_28_1 doi: 10.26508/lsa.202101317 – ident: e_1_2_10_13_1 doi: 10.1038/srep09495 – ident: e_1_2_10_3_1 doi: 10.6004/jnccn.2022.0002 – volume: 8 start-page: 778 year: 2018 ident: e_1_2_10_6_1 article-title: Lipid metabolism and carcinogenesis, cancer development publication-title: Am J Cancer Res contributor: fullname: Long J – ident: e_1_2_10_33_1 doi: 10.1016/j.cccn.2005.04.003 – ident: e_1_2_10_2_1 doi: 10.1182/blood-2008-12-194241 – ident: e_1_2_10_42_1 doi: 10.7554/eLife.57191 – ident: e_1_2_10_19_1 doi: 10.1007/s11883-021-00906-7 – ident: e_1_2_10_16_1 doi: 10.1186/s13045-020-00963-6 – ident: e_1_2_10_40_1 doi: 10.1002/ajh.25778 – ident: e_1_2_10_41_1 doi: 10.1200/JCO.2016.68.3482 – ident: e_1_2_10_35_1 doi: 10.1002/ijc.24668 – ident: e_1_2_10_14_1 doi: 10.1016/j.jacc.2009.12.069 – ident: e_1_2_10_37_1 doi: 10.1111/j.1365-2362.2007.01849.x – ident: e_1_2_10_4_1 doi: 10.1182/blood-2014-11-568881 – ident: e_1_2_10_5_1 doi: 10.1182/blood-2008-12-195008 – ident: e_1_2_10_31_1 doi: 10.1074/jbc.M113.468967 – ident: e_1_2_10_8_1 doi: 10.1126/science.1189731 – ident: e_1_2_10_23_1 – ident: e_1_2_10_43_1 doi: 10.1002/cam4.3937 – ident: e_1_2_10_44_1 doi: 10.1038/ni.3754 – ident: e_1_2_10_20_1 doi: 10.18637/jss.v045.i03 – ident: e_1_2_10_25_1 doi: 10.7554/eLife.34408 – ident: e_1_2_10_10_1 doi: 10.1016/j.jacl.2017.05.004 – ident: e_1_2_10_17_1 doi: 10.1038/s41375-020-01081-5 – ident: e_1_2_10_21_1 doi: 10.1002/sim.3618 – ident: e_1_2_10_11_1 doi: 10.3945/ajcn.115.124321 – ident: e_1_2_10_7_1 doi: 10.1093/cvr/cvu150 – ident: e_1_2_10_29_1 doi: 10.1016/j.semcancer.2020.10.007 – ident: e_1_2_10_30_1 doi: 10.1146/annurev-nutr-071811-150709 – ident: e_1_2_10_15_1 doi: 10.1002/ijc.30013 – ident: e_1_2_10_18_1 doi: 10.3390/cancers13030540 – volume: 26 start-page: 485 year: 1989 ident: e_1_2_10_22_1 article-title: Multiple imputation for nonresponse in surveys—Rubin, DB publication-title: J Marketing Res contributor: fullname: Campion WM – ident: e_1_2_10_32_1 doi: 10.1161/ATVBAHA.114.304006 – ident: e_1_2_10_12_1 doi: 10.1158/0008-5472.CAN-07-0212 |
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Snippet | Background
Plasma cell neoplasms are a group of hematologic neoplasms that often develop in the elderly population. The relationship between cholesterol levels... Plasma cell neoplasms are a group of hematologic neoplasms that often develop in the elderly population. The relationship between cholesterol levels and... Abstract Background Plasma cell neoplasms are a group of hematologic neoplasms that often develop in the elderly population. The relationship between... BackgroundPlasma cell neoplasms are a group of hematologic neoplasms that often develop in the elderly population. The relationship between cholesterol levels... BACKGROUNDPlasma cell neoplasms are a group of hematologic neoplasms that often develop in the elderly population. The relationship between cholesterol levels... We found that cholesterol profiles such as total cholesterol, HDL, LDL, apolipoprotein A, and apolipoprotein B were inversely correlated with the risk of... |
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SubjectTerms | Aged apolipoprotein Apolipoprotein A Apolipoprotein B Apolipoproteins A Apolipoproteins B Biobanks Biological Specimen Banks Biomarkers Body mass index Cholesterol Cholesterol, HDL Cholesterol, LDL Cohort analysis Cohort Studies Diabetes Disease High density lipoprotein Humans Lipids Low density lipoprotein Lung cancer Malignancy Metabolism Metabolites Multiple Myeloma Neoplasia Plasma plasma cell neoplasm Population studies Prospective Studies Risk Factors Triglycerides Tumors UK Biobank Variables |
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Title | Low cholesterol levels are associated with increasing risk of plasma cell neoplasm: A UK biobank cohort study |
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