The role of vascular adhesion protein‐1 in diabetes and diabetic complications

• Published in: Journal of diabetes investigation Vol. 15; no. 8; pp. 982 - 989
• Main Authors: Yen, I‐Weng, Li, Hung‐Yuan
• Format: Journal Article
• Language: English
• Published: Japan John Wiley & Sons, Inc 01.08.2024; John Wiley and Sons Inc; Wiley
• Subjects: Advanced glycosylation end products; Amine Oxidase (Copper-Containing) - blood; Amine Oxidase (Copper-Containing) - metabolism; Amines; Animals; Apolipoproteins; Atherosclerosis; Biomarkers; Cardiovascular disease; Cardiovascular diseases; Cell Adhesion Molecules - metabolism; Clinical trials; Coronary vessels; Diabetes; Diabetes Complications - etiology; Diabetes Complications - metabolism; Diabetes mellitus; Diabetes Mellitus - metabolism; diabetic complications; Diabetic nephropathy; Diabetic neuropathy; Diabetic retinopathy; Endothelium; Fatty liver; Glycation End Products, Advanced - metabolism; Humans; Hydrogen peroxide; Hyperglycemia; Inflammation; Kidney diseases; Leukocyte migration; Leukocytes; Liver cancer; Liver diseases; Lymphocytes; Monoclonal antibodies; Mortality; Nephropathy; Neuropathy; Oxidative stress; Pathophysiology; Patients; Plasma; Population studies; Proteins; Retinopathy; Review; Risk assessment; semicarbazide‐sensitive amine oxidase; Smooth muscle; Vascular adhesion protein‐1; Vein & artery diseases; New Zealand; diabetic complications; semicarbazide‐sensitive amine oxidase; Vascular adhesion protein‐1

ABSTRACT Vascular adhesion protein‐1 (VAP‐1) plays a dual role with its adhesive and enzymatic properties, facilitating leukocyte migration to sites of inflammation and catalyzing the breakdown of primary amines into harmful by‐products, which are linked to diabetic complications. Present in various...