Economic evaluation of Vacuum Assisted Closure® Therapy for the treatment of diabetic foot ulcers in France

The objective of the study was to assess the cost‐effectiveness of Vacuum Assisted Closure® (V.A.C.®) Therapy compared with advanced wound care (AWC) for the treatment of diabetic foot ulcers (DFUs) in France. A cost‐effectiveness model intended to reflect the management of DFUs was updated for the...

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Published in	International wound journal Vol. 8; no. 1; pp. 22 - 32
Main Authors	Whitehead, Sarah J, Forest-Bendien, Véronique L, Richard, Jean-Louis, Halimi, Serge, Ha Van, Georges, Trueman, Paul
Format	Journal Article
Language	English
Published	Oxford, UK Blackwell Publishing Ltd 01.02.2011
Subjects	Aged Cost-Benefit Analysis Cost-effectiveness Diabetic Foot - economics Diabetic Foot - epidemiology Diabetic Foot - therapy Diabetic foot ulcers Female France - epidemiology Humans Male Middle Aged Models, Economic Negative pressure therapy Negative-Pressure Wound Therapy - economics Negative-Pressure Wound Therapy - methods Original Treatment Outcome V.A.C.® Therapy France
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Abstract	The objective of the study was to assess the cost‐effectiveness of Vacuum Assisted Closure® (V.A.C.®) Therapy compared with advanced wound care (AWC) for the treatment of diabetic foot ulcers (DFUs) in France. A cost‐effectiveness model intended to reflect the management of DFUs was updated for the French setting. The Markov model follows the progression of 1000 hypothetical patients over a 1‐year period. The model was populated with French‐specific data, obtained from published sources and clinical experts. The analysis evaluated costs and health outcomes, in terms of quality‐adjusted life‐years (QALYs), wounds healed and amputations, from the perspective of the payer. The patients treated with V.A.C.® Therapy experienced more QALYs (0·787 versus 0·784) and improved healing rates (50·2% versus 48·5%) at a lower total cost of care (€24 881 versus €28 855 per patient per year) when compared with AWC. Sensitivity analyses conducted around key model parameters indicated that the results were affected by hospital resource use and costs. DFU treatment using V.A.C.® Therapy in France was associated with lower costs, additional QALYs, more healed ulcers and fewer amputations than treatment with AWC. V.A.C.® Therapy was therefore found to be the dominant treatment option.
AbstractList	The objective of the study was to assess the cost‐effectiveness of Vacuum Assisted Closure ® (V.A.C. ® ) Therapy compared with advanced wound care (AWC) for the treatment of diabetic foot ulcers (DFUs) in France. A cost‐effectiveness model intended to reflect the management of DFUs was updated for the French setting. The Markov model follows the progression of 1000 hypothetical patients over a 1‐year period. The model was populated with French‐specific data, obtained from published sources and clinical experts. The analysis evaluated costs and health outcomes, in terms of quality‐adjusted life‐years (QALYs), wounds healed and amputations, from the perspective of the payer. The patients treated with V.A.C. ® Therapy experienced more QALYs (0·787 versus 0·784) and improved healing rates (50·2% versus 48·5%) at a lower total cost of care (€24 881 versus €28 855 per patient per year) when compared with AWC. Sensitivity analyses conducted around key model parameters indicated that the results were affected by hospital resource use and costs. DFU treatment using V.A.C. ® Therapy in France was associated with lower costs, additional QALYs, more healed ulcers and fewer amputations than treatment with AWC. V.A.C. ® Therapy was therefore found to be the dominant treatment option. The objective of the study was to assess the cost‐effectiveness of Vacuum Assisted Closure® (V.A.C.®) Therapy compared with advanced wound care (AWC) for the treatment of diabetic foot ulcers (DFUs) in France. A cost‐effectiveness model intended to reflect the management of DFUs was updated for the French setting. The Markov model follows the progression of 1000 hypothetical patients over a 1‐year period. The model was populated with French‐specific data, obtained from published sources and clinical experts. The analysis evaluated costs and health outcomes, in terms of quality‐adjusted life‐years (QALYs), wounds healed and amputations, from the perspective of the payer. The patients treated with V.A.C.® Therapy experienced more QALYs (0·787 versus 0·784) and improved healing rates (50·2% versus 48·5%) at a lower total cost of care (€24 881 versus €28 855 per patient per year) when compared with AWC. Sensitivity analyses conducted around key model parameters indicated that the results were affected by hospital resource use and costs. DFU treatment using V.A.C.® Therapy in France was associated with lower costs, additional QALYs, more healed ulcers and fewer amputations than treatment with AWC. V.A.C.® Therapy was therefore found to be the dominant treatment option. The objective of the study was to assess the cost-effectiveness of Vacuum Assisted Closure® (V.A.C.®) Therapy compared with advanced wound care (AWC) for the treatment of diabetic foot ulcers (DFUs) in France. A cost-effectiveness model intended to reflect the management of DFUs was updated for the French setting. The Markov model follows the progression of 1000 hypothetical patients over a 1-year period. The model was populated with French-specific data, obtained from published sources and clinical experts. The analysis evaluated costs and health outcomes, in terms of quality-adjusted life-years (QALYs), wounds healed and amputations, from the perspective of the payer. The patients treated with V.A.C.® Therapy experienced more QALYs (0.787 versus 0.784) and improved healing rates (50.2% versus 48.5%) at a lower total cost of care (€24,881 versus €28,855 per patient per year) when compared with AWC. Sensitivity analyses conducted around key model parameters indicated that the results were affected by hospital resource use and costs. DFU treatment using V.A.C.® Therapy in France was associated with lower costs, additional QALYs, more healed ulcers and fewer amputations than treatment with AWC. V.A.C.® Therapy was therefore found to be the dominant treatment option.
Author	Trueman, Paul Halimi, Serge Forest-Bendien, Véronique L Richard, Jean-Louis Ha Van, Georges Whitehead, Sarah J
AuthorAffiliation	3 J‐L Richard, MD, Head of the Department of Nutritional Diseases and Diabetology, Service des Maladies de la Nutrition & Diabétologie, Centre Médical, Le Grau du Roi, University Hospital of Nîmes, France 5 G Ha Van, Medical Assistant in Diabetology and Endocrinology, Médecine Physique et Réadaptation, Clinique les Trois Soleils, Boissise le Roi, France 2 VL Forest‐Bendien, MSc, KCI Europe Holding, Amstelveen, The Netherlands 4 S Halimi, Professor of Nutrition Diabetology, Head of the Department, University Hospital Grenoble, Service d’Endocrinologie‐Diabétologie‐Nutrition, CHU Grenoble, 38043 Grenoble, France 6 P Trueman, MA, BA, Health Economics Research Group, Brunel University, London, UK 1 SJ Whitehead, MSc, BSc (Hons), York Trials Unit, Department of Health Sciences, University of York, Heslington, York, UK
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Snippet	The objective of the study was to assess the cost‐effectiveness of Vacuum Assisted Closure® (V.A.C.®) Therapy compared with advanced wound care (AWC) for the... The objective of the study was to assess the cost-effectiveness of Vacuum Assisted Closure® (V.A.C.®) Therapy compared with advanced wound care (AWC) for the... The objective of the study was to assess the cost‐effectiveness of Vacuum Assisted Closure ® (V.A.C. ® ) Therapy compared with advanced wound care (AWC) for...
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SubjectTerms	Aged Cost-Benefit Analysis Cost-effectiveness Diabetic Foot - economics Diabetic Foot - epidemiology Diabetic Foot - therapy Diabetic foot ulcers Female France - epidemiology Humans Male Middle Aged Models, Economic Negative pressure therapy Negative-Pressure Wound Therapy - economics Negative-Pressure Wound Therapy - methods Original Treatment Outcome V.A.C.® Therapy
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Title	Economic evaluation of Vacuum Assisted Closure® Therapy for the treatment of diabetic foot ulcers in France
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