An integrative model with HLA‐DR, CD64, and PD‐1 for the diagnostic and prognostic evaluation of sepsis

• Published in: Immunity, Inflammation and Disease Vol. 12; no. 1; pp. e1138 - n/a
• Main Authors: Chen, Guosheng, Chong, Huimin, Zhang, Peng, Wen, Dalin, Du, Juan, Gao, Chu, Zeng, Shi, Zeng, Ling, Deng, Jin, Zhang, Kejun, Zhang, Anqiang
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.01.2024; John Wiley and Sons Inc; Wiley
• Subjects: Antibodies; Biomarkers; Case-Control Studies; CD64; Critical Illness; Disease; Flow cytometry; HLA-DR Antigens; HLA‐DR; Humans; Infections; Medical prognosis; Microorganisms; Mortality; Original; PD‐1; predict; Prognosis; Programmed Cell Death 1 Receptor; Sepsis; Sepsis - diagnosis; Software; CD64; predict; HLA-DR; PD-1; sepsis

Background Sepsis is a life‐threatening organ dysfunction caused by a dysregulated host response to infection and progressive immunosuppression with high mortality. HLA‐DR, CD64, and PD‐1 were assumed to be useful biomarkers for sepsis prediction. However, the ability of a combination of these bioma...