SALL4 correlates with proliferation, metastasis, and poor prognosis in prostate cancer by affecting MAPK pathway

• Published in: Cancer medicine (Malden, MA) Vol. 12; no. 12; pp. 13471 - 13485
• Main Authors: Zhou, Jie, Peng, Shengmeng, Fan, Huiyang, Li, Jin, Li, Zean, Wang, Ganping, Zeng, Lexiang, Guo, Zhenghui, Lai, Yiming, Huang, Hai
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.06.2023; John Wiley and Sons Inc; Wiley
• Subjects: Angiogenesis; Apoptosis; Biopsy; Cell cycle; Cell Line, Tumor; Cell Movement - genetics; Cell proliferation; Cell Proliferation - genetics; Datasets; Gastric cancer; Gene expression; Gene Expression Regulation, Neoplastic; Humans; Leukemia; Male; MAP kinase; MAPK pathway; Medical prognosis; Metastases; Metastasis; p38 Protein; Phosphorylation; Polyethylene terephthalate; Prognosis; Prostate cancer; Prostatic Neoplasms - pathology; SALL4; Signal transduction; Software; Stem cells; Surgery; Therapeutic targets; Transcription factors; Transcription Factors - genetics; Transcription Factors - metabolism; Tumors; United States > US; China; MAPK pathway; prostate cancer; metastasis; SALL4

Background The mechanism involved in prostate cancer (PCa) metastasis is still poorly understood, and several oncogenes are known to regulate this process. However, the role of spalt‐like transcription factor 4 (SALL4) in PCa metastasis remains unclear. Methods We performed RNA‐sequencing to compare...