Progress towards a clinically-successful ATR inhibitor for cancer therapy

• Published in: Current research in pharmacology and drug discovery Vol. 2; p. 100017
• Main Authors: Barnieh, Francis M., Loadman, Paul M., Falconer, Robert A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2021; Elsevier
• Subjects: ATM; ATR; ATR inhibitors; Chemo- and radiosensitisers; DDR; Review; Chemo- and radiosensitisers; ATM; DDR; ATR inhibitors; ATR

The DNA damage response (DDR) is now known to play an important role in both cancer development and its treatment. Targeting proteins such as ATR (Ataxia telangiectasia mutated and Rad3-related) kinase, a major regulator of DDR, has demonstrated significant therapeutic potential in cancer treatment,...