Effective connectivity in the default mode network is distinctively disrupted in Alzheimer's disease—A simultaneous resting‐state FDG‐PET/fMRI study

• Published in: Human brain mapping Vol. 42; no. 13; pp. 4134 - 4143
• Main Authors: Scherr, Martin, Utz, Lukas, Tahmasian, Masoud, Pasquini, Lorenzo, Grothe, Michel J., Rauschecker, Josef P., Grimmer, Timo, Drzezga, Alexander, Sorg, Christian, Riedl, Valentin
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.09.2021
• Subjects: Advertising executives; Aged; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - metabolism; Alzheimer Disease - physiopathology; Alzheimer's disease; Brain mapping; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - metabolism; Cerebral Cortex - physiopathology; Cognitive ability; Connectome - methods; Cortex (parietal); default mode network; Default Mode Network - diagnostic imaging; Default Mode Network - metabolism; Default Mode Network - physiopathology; Development and progression; Diagnostic imaging; directional signaling; effective connectivity; energy metabolism; Functional magnetic resonance imaging; Hippocampus; Humans; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Medical imaging; Molecular modelling; Multimodal Imaging - methods; Neural networks; Neurodegenerative diseases; Neuroimaging; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; Prefrontal cortex; Proteins; resting state; Signal transduction; Signaling; simultaneous PET/fMRI; Tomography; Word of mouth advertising; simultaneous PET/fMRI; resting state; directional signaling; default mode network; energy metabolism; effective connectivity

A prominent finding of postmortem and molecular imaging studies on Alzheimer's disease (AD) is the accumulation of neuropathological proteins in brain regions of the default mode network (DMN). Molecular models suggest that the progression of disease proteins depends on the directionality of si...