Duloxetine for the Management of Diabetic Peripheral Neuropathic Pain: Evaluation of Functional Outcomes

• Published in: Pain medicine (Malden, Mass.) Vol. 8; no. 5; pp. 410 - 418
• Main Authors: Armstrong, David G., Chappell, Amy S., Le, Trong K., Kajdasz, Daniel K., Backonja, Miroslav, D'Souza, Deborah N., Russell, James M.
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.07.2007
• Subjects: Aged; Antidepressants; Diabetic Neuropathies - drug therapy; Diabetic Neuropathies - physiopathology; Diabetic Neuropathy; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Outcome Assessment (Health Care) - methods; Pain Measurement - drug effects; Pain Measurement - methods; Patient Satisfaction; Peripheral Nerves - drug effects; Peripheral Nerves - physiopathology; Placebos; Serotonin Uptake Inhibitors - administration & dosage; Serotonin Uptake Inhibitors - adverse effects; Surveys and Questionnaires; Thiophenes - administration & dosage; Thiophenes - adverse effects; Treatment Outcome

ABSTRACT Objective.  To assess the effectiveness of duloxetine, compared with placebo, on patient‐reported health outcomes over a 12‐week period, in the management of diabetic peripheral neuropathic pain (DPNP). Methods.  The results were pooled from three 12‐week multicenter, double‐blind studies....