MiR‐503 pleiotropically regulates epithelial‐mesenchymal transition and targets PTK7 to control lung cancer metastasis

• Published in: Cancer medicine (Malden, MA) Vol. 12; no. 13; pp. 14511 - 14525
• Main Authors: Tsai, Tzu‐Hsiu, Gow, Chien‐Hung, Liu, Yi‐Nan, Tsai, Meng‐Feng, Chang, Tzu‐Hua, Wu, Shang‐Gin, Hsieh, Min‐Shu, Su, Kang‐Yi, Shih, Jin‐Yuan
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.07.2023; John Wiley and Sons Inc; Wiley
• Subjects: Actin; actin cytoskeleton; Animal research; Cell adhesion & migration; Cell cycle; Cell migration; Cloning; Cytoskeleton; Cytotoxicity; epithelial‐mesenchymal transition; Focal adhesion kinase; Immunoblotting; Immunofluorescence; Kinases; Lung cancer; Metastases; Metastasis; MicroRNAs; miRNA; miR‐503; Paxillin; Phenotypes; protein tyrosine kinase 7; Protein-tyrosine kinase; Proteins; Therapeutic targets; Wnt protein; United States > US; actin cytoskeleton; protein tyrosine kinase 7; epithelial-mesenchymal transition; focal adhesion kinase; miR-503

Objective In lung cancer patients, most deaths are caused by the distant dissemination of cancer cells. Epithelial–mesenchymal transition (EMT) and collective cell migration are distinct and important mechanisms involved in cancer invasion and metastasis. Additionally, microRNA dysregulation contrib...