Exploring the presence of the GPR126 single nucleotide polymorphism (rs536714306) in periodontal patients of European ancestry

Objective G protein-coupled receptor 126 ( GPR126 ) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis...

Full description

Saved in:
Bibliographic Details
Published inBMC research notes Vol. 18; no. 1; pp. 370 - 5
Main Authors Chatzopoulou, Eirini, Fanourakis, Galinos, Papanikolaou, Nikolaos, Chatzistamou, Ioulia, Dereka, Xanthippi, Vastardis, Heleni
Format Journal Article
LanguageEnglish
Published London BioMed Central 22.08.2025
BioMed Central Ltd
BMC
Subjects
Adult
Alleles
Biomedical and Life Sciences
Biomedicine
Case-Control Studies
Dental research
Dentistry
Disease susceptibility
DNA sequencing
Female
G proteins
Gene polymorphism
Genes
Genetic aspects
Genetic Predisposition to Disease
Genomes
Genomics
Genotype
Genotype & phenotype
Genotyping
GPR126 gene
Greece
Gum disease
Homeostasis
Humans
Life Sciences
Ligaments
Male
Medical research
Medicine, Experimental
Medicine/Public Health
Membrane proteins
Middle Aged
Nucleotide sequencing
Periodontal diseases
Periodontitis
Periodontitis - genetics
Physiological aspects
Polymorphism
Polymorphism, Single Nucleotide
Population studies
Proteins
Receptors, G-Protein-Coupled - genetics
Research Note
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Susceptibility
White People - genetics
Greece
Europe
Periodontitis
gene
Polymorphism
GPR126 gene
Online AccessGet full text
ISSN1756-0500
1756-0500
DOI10.1186/s13104-025-07443-5

Cover

Abstract Objective G protein-coupled receptor 126 ( GPR126 ) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis in a Greek population and periodontal cases of European ancestry. A total of 82 subjects were recruited: 53 patients periodontally compromised (P) and 29 healthy controls (H). GPR126 genotyping was performed using Sanger sequencing. Additionally, data from the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) consortium were included in this study. Results No variants (rs536714306) in the GPR126 gene were detected in any of the samples. The homozygous for the reference allele GG genotype was observed in 100% of participants across all groups examined. Absence of GPR126 [c.3086 G > A] polymorphism indicates no association with susceptibility to periodontitis in a Greek cohort and periodontally compromised cases of European ancestry. This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility.
AbstractList G protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis in a Greek population and periodontal cases of European ancestry. A total of 82 subjects were recruited: 53 patients periodontally compromised (P) and 29 healthy controls (H). GPR126 genotyping was performed using Sanger sequencing. Additionally, data from the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) consortium were included in this study. No variants (rs536714306) in the GPR126 gene were detected in any of the samples. The homozygous for the reference allele GG genotype was observed in 100% of participants across all groups examined. Absence of GPR126 [c.3086 G > A] polymorphism indicates no association with susceptibility to periodontitis in a Greek cohort and periodontally compromised cases of European ancestry. This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility.
Objective G protein-coupled receptor 126 ( GPR126 ) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis in a Greek population and periodontal cases of European ancestry. A total of 82 subjects were recruited: 53 patients periodontally compromised (P) and 29 healthy controls (H). GPR126 genotyping was performed using Sanger sequencing. Additionally, data from the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) consortium were included in this study. Results No variants (rs536714306) in the GPR126 gene were detected in any of the samples. The homozygous for the reference allele GG genotype was observed in 100% of participants across all groups examined. Absence of GPR126 [c.3086 G > A] polymorphism indicates no association with susceptibility to periodontitis in a Greek cohort and periodontally compromised cases of European ancestry. This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility.
ObjectiveG protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis in a Greek population and periodontal cases of European ancestry. A total of 82 subjects were recruited: 53 patients periodontally compromised (P) and 29 healthy controls (H). GPR126 genotyping was performed using Sanger sequencing. Additionally, data from the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) consortium were included in this study.ResultsNo variants (rs536714306) in the GPR126 gene were detected in any of the samples. The homozygous for the reference allele GG genotype was observed in 100% of participants across all groups examined. Absence of GPR126 [c.3086 G > A] polymorphism indicates no association with susceptibility to periodontitis in a Greek cohort and periodontally compromised cases of European ancestry. This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility.
G protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis in a Greek population and periodontal cases of European ancestry. A total of 82 subjects were recruited: 53 patients periodontally compromised (P) and 29 healthy controls (H). GPR126 genotyping was performed using Sanger sequencing. Additionally, data from the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) consortium were included in this study. No variants (rs536714306) in the GPR126 gene were detected in any of the samples. The homozygous for the reference allele GG genotype was observed in 100% of participants across all groups examined. Absence of GPR126 [c.3086 G > A] polymorphism indicates no association with susceptibility to periodontitis in a Greek cohort and periodontally compromised cases of European ancestry. This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility.
Objective G protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis in a Greek population and periodontal cases of European ancestry. A total of 82 subjects were recruited: 53 patients periodontally compromised (P) and 29 healthy controls (H). GPR126 genotyping was performed using Sanger sequencing. Additionally, data from the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) consortium were included in this study. Results No variants (rs536714306) in the GPR126 gene were detected in any of the samples. The homozygous for the reference allele GG genotype was observed in 100% of participants across all groups examined. Absence of GPR126 [c.3086 G > A] polymorphism indicates no association with susceptibility to periodontitis in a Greek cohort and periodontally compromised cases of European ancestry. This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility. Keywords: Periodontitis, GPR126 gene, Polymorphism
G protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis in a Greek population and periodontal cases of European ancestry. A total of 82 subjects were recruited: 53 patients periodontally compromised (P) and 29 healthy controls (H). GPR126 genotyping was performed using Sanger sequencing. Additionally, data from the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) consortium were included in this study.OBJECTIVEG protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis in a Greek population and periodontal cases of European ancestry. A total of 82 subjects were recruited: 53 patients periodontally compromised (P) and 29 healthy controls (H). GPR126 genotyping was performed using Sanger sequencing. Additionally, data from the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) consortium were included in this study.No variants (rs536714306) in the GPR126 gene were detected in any of the samples. The homozygous for the reference allele GG genotype was observed in 100% of participants across all groups examined. Absence of GPR126 [c.3086 G > A] polymorphism indicates no association with susceptibility to periodontitis in a Greek cohort and periodontally compromised cases of European ancestry. This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility.RESULTSNo variants (rs536714306) in the GPR126 gene were detected in any of the samples. The homozygous for the reference allele GG genotype was observed in 100% of participants across all groups examined. Absence of GPR126 [c.3086 G > A] polymorphism indicates no association with susceptibility to periodontitis in a Greek cohort and periodontally compromised cases of European ancestry. This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility.
Abstract Objective G protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis in a Greek population and periodontal cases of European ancestry. A total of 82 subjects were recruited: 53 patients periodontally compromised (P) and 29 healthy controls (H). GPR126 genotyping was performed using Sanger sequencing. Additionally, data from the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) consortium were included in this study. Results No variants (rs536714306) in the GPR126 gene were detected in any of the samples. The homozygous for the reference allele GG genotype was observed in 100% of participants across all groups examined. Absence of GPR126 [c.3086 G > A] polymorphism indicates no association with susceptibility to periodontitis in a Greek cohort and periodontally compromised cases of European ancestry. This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility.
ArticleNumber 370
Audience Academic
Author Chatzistamou, Ioulia
Fanourakis, Galinos
Chatzopoulou, Eirini
Papanikolaou, Nikolaos
Vastardis, Heleni
Dereka, Xanthippi
Author_xml – sequence: 1
  givenname: Eirini
  surname: Chatzopoulou
  fullname: Chatzopoulou, Eirini
  organization: U.F.R. d’Odontologie, Université Paris Cité, Service of Odontology, Periodontal and Oral Surgery Unit, Rothschild Hospital (AP-HP)
– sequence: 2
  givenname: Galinos
  surname: Fanourakis
  fullname: Fanourakis, Galinos
  email: gfanourak@med.uoa.gr
  organization: Department of Oral Biology, School of Dentistry, National and Kapodistrian University of Athens
– sequence: 3
  givenname: Nikolaos
  surname: Papanikolaou
  fullname: Papanikolaou, Nikolaos
  organization: EnzyQuest PC, Science and Technology Park of Crete
– sequence: 4
  givenname: Ioulia
  surname: Chatzistamou
  fullname: Chatzistamou, Ioulia
  organization: Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina
– sequence: 5
  givenname: Xanthippi
  surname: Dereka
  fullname: Dereka, Xanthippi
  organization: Department of Periodontology, School of Dentistry, National and Kapodistrian University of Athens
– sequence: 6
  givenname: Heleni
  surname: Vastardis
  fullname: Vastardis, Heleni
  organization: Department of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens
BackLink https://www.ncbi.nlm.nih.gov/pubmed/40846985$$D View this record in MEDLINE/PubMed
BookMark eNp9kktr3DAUhU1JaR7tH-iiGLpJFk4l670qIUzTgUBKabsVsizNKNiSK9khs-lvrzyTJplSihG2pe-cy706x8WBD94UxVsIziHk9EOCCAJcgZpUgGGMKvKiOIKM0AoQAA6efR8WxyndAkAh5_BVcYgBx1RwclT8WtwPXYjOr8pxbcohmmS8NmWw2_-rL19hTcuUzztT-kl3JoyuzWDoNn2Iw9qlvjyNiSDKIEaAnpXOl4OJLrTBj6orBzU648c0Wy6mGAajfKlyjTTGzevipVVdMm8e3ifF90-Lb5efq-ubq-XlxXWlCQSkalSD2gaIhiJUG2IYaLhgAtYEkLa2kAhkEFNAIWE1VJQxTCzRVAErgG0wOimWO982qFs5RNeruJFBObndCHElVRxdbk82jaFaMC6yAW654YRbm2ty3QjWapi9Pu68hqnpTatzc1F1e6b7J96t5SrcSVijfE2QZYfTB4cYfk55ELJ3SZuuU96EKUlUY5oXJjP6_i_0NkzR51nNFIMEClQ_USuVO3DehlxYz6bygpNaIM4AzdT5P6j8tKZ3OmfLury_JzjbE2RmNPfjSk0pyeXNj3323fOpPI7jT9QyUO8AHUNK0dhHBAI551nu8ixznuU2z3IWoZ0oDXNGTXxq_z-q37UW9Ow
Cites_doi 10.1016/j.febslet.2004.05.038
10.1371/journal.pgen.1000445
10.1016/j.ajhg.2015.04.014
10.1242/dev.098061
10.1038/s41598-024-54179-6
10.1172/JCI34772
10.1038/ng.500
10.1016/j.gendis.2023.02.016
10.1038/nature19312
10.1111/j.1600-0757.2010.00371.x
10.1111/j.1600-0757.2011.00415.x
10.1016/j.neuron.2014.12.057
10.1016/S0006-291X(03)00026-3
10.3389/fphar.2024.1349097
10.1177/0022034519842510
10.3233/CBM-170541
10.1038/ng.2639
10.1016/j.gene.2006.07.039
10.1038/nrm908
10.1074/jbc.M114.571000
10.1126/scisignal.2005347
10.1124/mol.63.6.1256
10.1126/science.1173474
10.1242/dev.093401
10.1038/s41598-023-50600-8
10.1007/s00784-022-04420-1
10.1371/journal.pone.0014047
10.1371/journal.pone.0160765
10.1111/jre.12167
10.1111/j.1356-9597.2004.00743.x
10.1038/s41467-019-10630-1
ContentType Journal Article
Copyright The Author(s) 2025
2025. The Author(s).
COPYRIGHT 2025 BioMed Central Ltd.
2025. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
The Author(s) 2025 2025
Copyright_xml – notice: The Author(s) 2025
– notice: 2025. The Author(s).
– notice: COPYRIGHT 2025 BioMed Central Ltd.
– notice: 2025. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: The Author(s) 2025 2025
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
IOV
3V.
7X7
7XB
88E
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M7P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
7X8
5PM
DOA
DOI 10.1186/s13104-025-07443-5
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Gale In Context: Opposing Viewpoints
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One
ProQuest Central Korea
Health Research Premium Collection (UHCL Subscription)
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Biological Science Database
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE

Publicly Available Content Database



MEDLINE - Academic
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
Dentistry
EISSN 1756-0500
EndPage 5
ExternalDocumentID oai_doaj_org_article_bbe6c9789f5c4d8e858ffe5e8cb97dc1
PMC12374417
A852938706
40846985
10_1186_s13104_025_07443_5
Genre Journal Article
GeographicLocations Greece
Europe
GeographicLocations_xml – name: Greece
– name: Europe
GroupedDBID ---
0R~
23N
2WC
53G
5GY
5VS
6J9
7X7
88E
8FE
8FH
8FI
8FJ
AAFWJ
AAJSJ
AASML
ABDBF
ABUWG
ACGFO
ACGFS
ACIHN
ACMJI
ACPRK
ACUHS
ADBBV
ADRAZ
ADUKV
AEAQA
AFKRA
AFPKN
AHBYD
AHMBA
AHYZX
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMTXH
AOIJS
BAPOH
BAWUL
BBNVY
BCNDV
BENPR
BFQNJ
BHPHI
BMC
BPHCQ
BVXVI
C6C
CCPQU
CS3
DIK
E3Z
EBD
EBLON
EBS
EMOBN
ESX
F5P
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HMCUK
HYE
IAO
IEA
IHR
INH
INR
IOV
ITC
KQ8
LGEZI
LK8
LOTEE
M1P
M7P
MK0
M~E
NADUK
NXXTH
O5R
O5S
OK1
OVT
P2P
PGMZT
PHGZM
PHGZT
PIMPY
PJZUB
PPXIY
PQGLB
PQQKQ
PROAC
PSQYO
PUEGO
RBZ
RNS
ROL
RPM
RSV
SBL
SOJ
SV3
TR2
TUS
UKHRP
~8M
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7XB
8FK
AZQEC
DWQXO
GNUQQ
K9.
M48
PKEHL
PQEST
PQUKI
7X8
5PM
ID FETCH-LOGICAL-c5105-bab3db09b6332e5e70b897912505d2f1593e37a0a39fc1a67745f5c6a0f90fb43
IEDL.DBID DOA
ISSN 1756-0500
IngestDate Wed Aug 27 01:30:51 EDT 2025
Wed Aug 27 05:41:58 EDT 2025
Thu Sep 04 12:32:20 EDT 2025
Sat Sep 06 11:10:11 EDT 2025
Wed Aug 27 16:51:22 EDT 2025
Tue Sep 02 03:58:04 EDT 2025
Fri Aug 29 03:31:43 EDT 2025
Thu Sep 04 05:02:57 EDT 2025
Wed Aug 27 16:25:09 EDT 2025
Sat Sep 06 07:31:25 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Periodontitis
gene
Polymorphism
GPR126 gene
Language English
License 2025. The Author(s).
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c5105-bab3db09b6332e5e70b897912505d2f1593e37a0a39fc1a67745f5c6a0f90fb43
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
OpenAccessLink https://doaj.org/article/bbe6c9789f5c4d8e858ffe5e8cb97dc1
PMID 40846985
PQID 3247151932
PQPubID 55247
PageCount 5
ParticipantIDs doaj_primary_oai_doaj_org_article_bbe6c9789f5c4d8e858ffe5e8cb97dc1
pubmedcentral_primary_oai_pubmedcentral_nih_gov_12374417
proquest_miscellaneous_3246324457
proquest_journals_3247151932
gale_infotracmisc_A852938706
gale_infotracacademiconefile_A852938706
gale_incontextgauss_IOV_A852938706
pubmed_primary_40846985
crossref_primary_10_1186_s13104_025_07443_5
springer_journals_10_1186_s13104_025_07443_5
PublicationCentury 2000
PublicationDate 20250822
PublicationDateYYYYMMDD 2025-08-22
PublicationDate_xml – month: 8
  year: 2025
  text: 20250822
  day: 22
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle BMC research notes
PublicationTitleAbbrev BMC Res Notes
PublicationTitleAlternate BMC Res Notes
PublicationYear 2025
Publisher BioMed Central
BioMed Central Ltd
BMC
Publisher_xml – name: BioMed Central
– name: BioMed Central Ltd
– name: BMC
References H Waller-Evans (7443_CR11) 2010; 5
DB Hancock (7443_CR21) 2010; 42
ML Laine (7443_CR2) 2012; 58
L Hose (7443_CR27) 2024; 14
R Fredriksson (7443_CR6) 2003; 63
TA Manolio (7443_CR31) 2008; 118
G Ravenscroft (7443_CR23) 2015; 96
RD Vaithilingam (7443_CR32) 2014; 49
KR Monk (7443_CR14) 2009; 325
F-S Geng (7443_CR12) 2013; 140
I Kou (7443_CR19) 2013; 45
KL Pierce (7443_CR5) 2002; 3
T Moriguchi (7443_CR29) 2004; 9
MS Tonetti (7443_CR25) 2018; 45
J Kitagaki (7443_CR24) 2016; 11
A Küffer (7443_CR18) 2016; 536
R Fredriksson (7443_CR9) 2003; 301
F Schwendicke (7443_CR33) 2022; 26
SC Petersen (7443_CR17) 2015; 85
Q Li (7443_CR8) 2024; 11
A Jobe (7443_CR15) 2024; 15
7443_CR20
TD Glenn (7443_CR10) 2013; 140
7443_CR28
N Lu (7443_CR22) 2017; 21
TE Van Dyke (7443_CR1) 2005; 7
J Zhang (7443_CR4) 2011; 56
C Stehlik (7443_CR30) 2004; 569
H Cui (7443_CR13) 2014; 289
L Nibali (7443_CR3) 2019; 98
TK Bjarnadóttir (7443_CR7) 2007; 387
DL Pearce (7443_CR26) 2024; 14
KJ Paavola (7443_CR16) 2014; 7
References_xml – volume: 569
  start-page: 149
  year: 2004
  ident: 7443_CR30
  publication-title: FEBS Lett
  doi: 10.1016/j.febslet.2004.05.038
– volume: 45
  start-page: S149
  year: 2018
  ident: 7443_CR25
  publication-title: J Clin Periodontol
– ident: 7443_CR20
  doi: 10.1371/journal.pgen.1000445
– volume: 96
  start-page: 955
  year: 2015
  ident: 7443_CR23
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2015.04.014
– volume: 140
  start-page: 4362
  year: 2013
  ident: 7443_CR12
  publication-title: Development
  doi: 10.1242/dev.098061
– volume: 7
  start-page: 3
  year: 2005
  ident: 7443_CR1
  publication-title: J Int Acad Periodontol
– volume: 14
  start-page: 1
  year: 2024
  ident: 7443_CR27
  publication-title: Sci Rep
  doi: 10.1038/s41598-024-54179-6
– volume: 118
  start-page: 1590
  year: 2008
  ident: 7443_CR31
  publication-title: J Clin Invest
  doi: 10.1172/JCI34772
– volume: 42
  start-page: 45
  year: 2010
  ident: 7443_CR21
  publication-title: Nat Genet
  doi: 10.1038/ng.500
– volume: 11
  start-page: 294
  year: 2024
  ident: 7443_CR8
  publication-title: Genes Dis
  doi: 10.1016/j.gendis.2023.02.016
– volume: 536
  start-page: 464
  year: 2016
  ident: 7443_CR18
  publication-title: Nature
  doi: 10.1038/nature19312
– volume: 56
  start-page: 102
  year: 2011
  ident: 7443_CR4
  publication-title: Periodontol 2000
  doi: 10.1111/j.1600-0757.2010.00371.x
– volume: 58
  start-page: 37
  year: 2012
  ident: 7443_CR2
  publication-title: Periodontol 2000
  doi: 10.1111/j.1600-0757.2011.00415.x
– volume: 85
  start-page: 755
  year: 2015
  ident: 7443_CR17
  publication-title: Neuron
  doi: 10.1016/j.neuron.2014.12.057
– volume: 301
  start-page: 725
  year: 2003
  ident: 7443_CR9
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/S0006-291X(03)00026-3
– volume: 15
  start-page: 1
  year: 2024
  ident: 7443_CR15
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2024.1349097
– volume: 98
  start-page: 632
  year: 2019
  ident: 7443_CR3
  publication-title: J Dent Res
  doi: 10.1177/0022034519842510
– volume: 21
  start-page: 161
  year: 2017
  ident: 7443_CR22
  publication-title: Cancer Biomark
  doi: 10.3233/CBM-170541
– volume: 45
  start-page: 676
  year: 2013
  ident: 7443_CR19
  publication-title: Nat Genet
  doi: 10.1038/ng.2639
– volume: 387
  start-page: 38
  year: 2007
  ident: 7443_CR7
  publication-title: Gene
  doi: 10.1016/j.gene.2006.07.039
– volume: 3
  start-page: 639
  year: 2002
  ident: 7443_CR5
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm908
– volume: 289
  start-page: 34871
  year: 2014
  ident: 7443_CR13
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M114.571000
– volume: 7
  start-page: ra76
  year: 2014
  ident: 7443_CR16
  publication-title: Sci Signal
  doi: 10.1126/scisignal.2005347
– volume: 63
  start-page: 1256
  year: 2003
  ident: 7443_CR6
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.63.6.1256
– volume: 325
  start-page: 1402
  year: 2009
  ident: 7443_CR14
  publication-title: Science
  doi: 10.1126/science.1173474
– volume: 140
  start-page: 3167
  year: 2013
  ident: 7443_CR10
  publication-title: Dev
  doi: 10.1242/dev.093401
– volume: 14
  start-page: 1
  year: 2024
  ident: 7443_CR26
  publication-title: Sci Rep
  doi: 10.1038/s41598-023-50600-8
– volume: 26
  start-page: 3395
  year: 2022
  ident: 7443_CR33
  publication-title: Clin Oral Investig
  doi: 10.1007/s00784-022-04420-1
– volume: 5
  start-page: 1
  year: 2010
  ident: 7443_CR11
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0014047
– volume: 11
  start-page: 1
  year: 2016
  ident: 7443_CR24
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0160765
– volume: 49
  start-page: 683
  year: 2014
  ident: 7443_CR32
  publication-title: J Periodontal Res
  doi: 10.1111/jre.12167
– volume: 9
  start-page: 549
  year: 2004
  ident: 7443_CR29
  publication-title: Genes Cells
  doi: 10.1111/j.1356-9597.2004.00743.x
– ident: 7443_CR28
  doi: 10.1038/s41467-019-10630-1
SSID ssj0061881
Score 2.394749
Snippet Objective G protein-coupled receptor 126 ( GPR126 ) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese...
G protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This...
Objective G protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese...
ObjectiveG protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese...
Abstract Objective G protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in...
SourceID doaj
pubmedcentral
proquest
gale
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 370
SubjectTerms Adult
Alleles
Biomedical and Life Sciences
Biomedicine
Case-Control Studies
Dental research
Dentistry
Disease susceptibility
DNA sequencing
Female
G proteins
Gene polymorphism
Genes
Genetic aspects
Genetic Predisposition to Disease
Genomes
Genomics
Genotype
Genotype & phenotype
Genotyping
GPR126 gene
Greece
Gum disease
Homeostasis
Humans
Life Sciences
Ligaments
Male
Medical research
Medicine, Experimental
Medicine/Public Health
Membrane proteins
Middle Aged
Nucleotide sequencing
Periodontal diseases
Periodontitis
Periodontitis - genetics
Physiological aspects
Polymorphism
Polymorphism, Single Nucleotide
Population studies
Proteins
Receptors, G-Protein-Coupled - genetics
Research Note
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Susceptibility
White People - genetics
SummonAdditionalLinks – databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELZgKwQXBOUVKMggJEA0ah6245xQCy0FiVJVFPVmxY5dVmqTZbN76IXfzozjbEkRHHcz2bU945nP9vgbQl5CUGAQSTQYr7UxA2AUS45MmNyVVeokK33K_5cDsX_MPp_wk7Dh1oW0ysEnekddtwb3yLcg8BephxvvZj9jrBqFp6uhhMZ1sgYuWPIJWdvZPTg8GnyxSKVMh6syUmx1KaAZFmMJVwid0CQ-Ckeetf9v3_xHcLqaOHnl9NQHpb075HZAk3S7V_9dcs026-RGX1_yYp3c_IC5QFjO7R75tcq2o4D56MxfOzKWts5__nh4lGaC4s7BmaUNshy3i2kNgu3ZxXkL2ph25_T1vOO5wGLmiXhDpw1FnmRY2OKVShooWjv8yWGTn6JRYQPuk-O93W_v9-NQfCE2iLliXem81kmpRZ5nltsi0bIsyhQhU505QEG5zYsqqfLSmbQSACO540ZUiSsTp1n-gEyatrGPCM11XZoi1QVeii2k0ZlmyD_KDa62ah6Rt4MO1Kzn2FB-bSKF6jWmQGPKa0yB9A6qaSWJ_Nj-i3Z-qsJ0U1pbYWCBXEKTWC2t5NI56AX8eVnUJo3IC1SyQgaMBlNsTqtl16lPX7-rbckBAuHxb0ReBSHXgrpNFW4sQK-QNGskuTGShClqxo8HW1LBRXTq0qAj8nz1GN_EtLfGtksvg3T6jBcRedib3qrfLJFY_RPGQ46McjQw4yfN9IcnEAe0UmDpuYhsDvZ72a5_j_zj_3fjCbmV-ZkFrjfbIJPFfGmfAmJb6GdhWv4G3BQ8Ow
  priority: 102
  providerName: ProQuest
– databaseName: Springer Nature OA Free Journals
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELagCIkL4k2gVAYhAYKIOPHz2FaUgsRDiKLerNix25VKUjW7By78dmacZGkKHDhuPMnGnrHnm9jzDSFPwSlw8CQOjDeEnAMwyrVAJkwRTc2i5iYd-f_wUe4f8PeH4nCkycFcmPP790zL1z0D_MFzLLoKzg4eIi6TKwJ5xnBjVu5Oq65kWrMpKeav980cT-Ln_3MVPueGLh6RvLBPmtzP3g1yfcSNdHtQ9E1yKbS3yNWhkuSP2-Tn-iwdBURHT1NSkQ-0i-n3289fWCkpfhc4CbRFDuNuuWhAsDuB4B_GetF_p8_PegFdBmxTyBd00VJkQYawFRMm6UjA2uMjp0_4FE0Gq8XdIQd7b77u7udjaYXcI6LKXe2qxhXGyaoqgwiqcNoowxAQNWUEjFOFStVFXZnoWS0BJIoovKyLaIroeHWXbLRdG-4TWrnGeMWcwpRXpb0rHUd2UeExlmpERl5O425PBwYNmyIPLe2gJQtasklLFqR3UDVrSWS_ThfAKOw4maxzQXoIfw28Em900ELHCL2APzeq8SwjT1CxFvktWjxAc1Sv-t6--_TNbmsBAAc3dzPybBSKHajY12M-AvQKKbFmkpszSZiAft482Y8dF4DeAk5VLKHjjDxeN-OdeKitDd0qySBZPhcqI_cGc1v3mxcaa3vCeOiZIc4GZt7SLo4TPThgEYWF5TLyarLZ3-_175F_8H_iD8m1Ms0uWGjLTbKxPFuFR4DPlm4rTcxfZO4v0Q
  priority: 102
  providerName: Springer Nature
Title Exploring the presence of the GPR126 single nucleotide polymorphism (rs536714306) in periodontal patients of European ancestry
URI https://link.springer.com/article/10.1186/s13104-025-07443-5
https://www.ncbi.nlm.nih.gov/pubmed/40846985
https://www.proquest.com/docview/3247151932
https://www.proquest.com/docview/3246324457
https://pubmed.ncbi.nlm.nih.gov/PMC12374417
https://doaj.org/article/bbe6c9789f5c4d8e858ffe5e8cb97dc1
Volume 18
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELagCIkL4t1AWRmEBAii5uFXjttVS1mJUhWKerNix4aV2qRqdg-98NuZcZKlKUJcOK02nl05M2PPN8n4G0JeQVBgEEkMOK9zMQNgFCuOTJjcF2XqFStCyf-nA7F_zOYn_ORKqy-sCevogTvFbRvjhIVUp_Dcsko5xZX3jjtlTSErGxIfiHlDMtXtwSJVKh2OyCix3aaAYliMrVshZMJU-CgMBbb-P_fkK0HpesHktbemIRjt3SN3exRJp93s75Mbrn5Abnd9JS8fkp_ryjoK-I6ehyNG1tHGh-8fDo_STFB8SnDqaI2Mxs1yUYFgc3p51oDmF-0ZfXPR8lxg4_JEvKWLmiInMiSxeHyS9nSsLf7l8ECfogNh77hH5Hhv9-tsP-4bLcQW8VVsSpNXJimMyPMMdCsTowpZpAiPqswD4sldLsukzAtv01IAZORgDlEmvki8YfljslE3tdskNDdVYWVqJB6AlWCkzDDkGuUWM6uKR-TdoHd93vFp6JCHKKE7K2mwkg5W0iC9g6ZZSyIXdrgAHqJ7D9H_8pCIvETDamS7qLGc5nu5alv98fM3PVUc4A6-6o3I617IN2BiW_anE-CukCBrJLk1koTlaMfDg__ofjtoNaBWmQasHJEX62H8JZa41a5ZBRmkzmdcRuRJ527r-2aJwk6foA81csSRYsYj9eJHIAsHZCKxzVxE3g8--3tef9f80_-h-WfkThbWHGzG2RbZWF6s3HPAcEszITfliZyQW9Pp_MscPnd2Dw6P4OpMzCZhKf8CD9RGVA
linkProvider Directory of Open Access Journals
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELfGJjReEIyvwACDQDBBtHw5cR4Q2thGy7YyTRvam4kde1TaktK0Qn3hT-Jv5M5JOjIEb3tsfU1t3_nud_F9EPICjEIElkSC8GrtRgCMXM6wEiYzaeYbHqU25H9_EPeOo08n7GSB_GpzYTCsstWJVlHnpcJ35Otg-BPfwo33o-8udo3C29W2hUYtFrt69gNctupdfwv4-zIIdraPPvTcpquAqxBMuDKTYS69VMZhGGimE0_yNEl9xAJ5YMC8hzpMMi8LU6P8LAZ8xAxTceaZ1DMyCuG518gSwIwUTtHS5vbg4LDV_bHPud-m5vB4vfIBPUUutowFUw1bwDrmz3YJ-NsW_GEMLwdqXrqttUZw5xa52aBXulGL222yoIsVcr3uZzlbIctbGHuE7ePukJ_z6D4KGJOObJqT0rQ09vPHg0M_iCm-qTjTtMCqyuVkmANheTY7L4H7w-qcvh5XLIyxeboXr9FhQbEuMzjSmMJJm5KwFT6yvVSgKMQ4gbvk-ErYco8sFmWhHxAayjxViS8TTMJNuJKBjLDeKVPo3eXMIW9aHohRXdNDWF-Ix6LmmACOCcsxAdSbyKY5Jdbjtl-U41PRHG8hpY4VOOQpTCnKueaMGwOrgD9Pk1z5DnmOTBZYcaPAkJ7TbFpVov_5i9jgDCAXXjc75FVDZEpgt8qaDAlYFRbp6lCudihBJajucCtLolFJlbg4QA55Nh_GX2KYXaHLqaXB8v0RSxxyvxa9-bojj2O3UdgP3hHKzsZ0R4rhN1uwHNBRgq3uHPK2ld-Lef175x_-fxlPyXLvaH9P7PUHu4_IjcCeMlD7wSpZnIyn-jGgxYl80hxRSr5etVb4DTm5d_w
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZgK1AviDeBAgYhAYKocRI7znF5LO0CpQKKerNix25XapPVZvfQC7-dGSdZmgIHjhtPsrFn7Pkcz3xDyDNwCil4Eg3Ga22YAjAKJUcmTO7ygjmZ5j7k__Oe2DlIp4f88FwWv492748k25wGZGmqltvz0rVTXIrthgEqSUMsxQouEB7NL5MNKQA-jMjGeDz9Nu1XY8GkZH2yzF_vHDgkz9v_5-p8zj1dDJ28cH7q3dLkOrnW4Uk6bg3gBrlkq5vkSlth8uwW-bmOsaOA9OjcJxsZS2vnf3_Y_8piQfF7wYmlFXIb18tZCYL1ydlpDTqYNaf0xaLhicAS5pF4SWcVRXZk2M5iIiXtiFkbfGT_aZ-iKWEVudvkYPL--9udsCu5EBpEWqEudFLqKNciSWLLbRZpmWc5Q6BUxg6wT2KTrIiKJHeGFQLAI3fciCJyeeR0mtwho6qu7D1CE13mJmM6w1TYTBod6xRZR7nBPVbJA_KqH3c1b5k1lN-RSKFaLSnQkvJaUiD9BlWzlkRWbH-hXhypbpIpra0wsC3O4ZXSUlrJpXPQC_jzPCsNC8hTVKxC3osKA2uOilXTqN0vP9RYcgA-eOgbkOedkKtBxabo8hSgV0iVNZDcGkjCxDTD5t5-VLcwNArwa8Y8ag7Ik3Uz3onBbpWtV14GSfRTngXkbmtu636nkcSanzAecmCIg4EZtlSzY08bDhglw4JzAXnd2-zv9_r3yN__P_HH5Or-u4n6tLv38QHZjP1Eg7U43iKj5WJlHwKEW-pH3Sz9BatSPGw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Exploring+the+presence+of+the+GPR126+single+nucleotide+polymorphism+%28rs536714306%29+in+periodontal+patients+of+European+ancestry&rft.jtitle=BMC+research+notes&rft.au=Chatzopoulou%2C+Eirini&rft.au=Fanourakis%2C+Galinos&rft.au=Papanikolaou%2C+Nikolaos&rft.au=Chatzistamou%2C+Ioulia&rft.date=2025-08-22&rft.issn=1756-0500&rft.eissn=1756-0500&rft.volume=18&rft.issue=1&rft_id=info:doi/10.1186%2Fs13104-025-07443-5&rft.externalDBID=n%2Fa&rft.externalDocID=10_1186_s13104_025_07443_5
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1756-0500&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1756-0500&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1756-0500&client=summon